(92 nodes) Positive regulation of endopeptidase activity network (Xenopus tropicalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	tpm3	Tropomyosin 3. (197 aa)
	ENSXETP00000000456	Uncharacterized protein. (198 aa)
	tnf	Thyrotropin-releasing hormone receptor 3. (227 aa)
	hip1r	Uncharacterized protein. (1066 aa)
	cycs	Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	MALT1	MALT1 paracaspase. (799 aa)
	vsir	Hypothetical LOC496981. (289 aa)
	atp2a3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
	cradd.2	Colony stimulating factor 2 receptor beta common subunit. (197 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (523 aa)
	casp10	Casp10 protein; Belongs to the peptidase C14A family. (519 aa)
	tfap4	RNA binding motif protein 28. (333 aa)
	casp8	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
	arl6ip5	PRA1 family protein. (188 aa)
	PDCD2	Programmed cell death 2. (369 aa)
	cyfip2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1266 aa)
	bcl2l11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
	bcl10	Solute carrier family 35 (GDP-fucose transporter), member C2. (236 aa)
	GRAMD4	GRAM domain containing 4. (592 aa)
	ccn1	Histone deacetylase 2. (376 aa)
	bax	BCL2-associated X protein. (221 aa)
	LOC100493091	Dual specificity phosphatase 14. (231 aa)
	fas	Vitamin D receptor. (320 aa)
	prelid1	Janus kinase 3 (a protein tyrosine kinase, leukocyte). (216 aa)
	ENSXETP00000011099	Uncharacterized protein. (197 aa)
	htra2	Zic family member 4. (230 aa)
	efna1	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (146 aa)
	pdcd5	Uncharacterized protein. (125 aa)
	uaca	Cell division cycle 14B. (1389 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	CASP8AP2	Uncharacterized protein. (1824 aa)
	st18	CECR2, histone acetyl-lysine reader. (1007 aa)
	elp2	Elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the WD repeat ELP2 family. (832 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (463 aa)
	diablo	Diablo homolog, mitochondrial; Promotes apoptosis. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). (244 aa)
	adrm1	Proteasomal ubiquitin receptor ADRM1; Functions as a proteasomal ubiquitin receptor. Promotes the deubiquitinating activity associated with the 26S proteasome (By similarity); Belongs to the ADRM1 family. (417 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	stat3.2	STAT_int domain-containing protein. (408 aa)
	stat3.1	Signal transducer and activator of transcription. (715 aa)
	mul1a	Potassium channel, voltage gated subfamily A regulatory beta subunit 1. (352 aa)
	ift57	Intraflagellar transport protein 57 homolog; Required for the formation of cilia. May also have pro- apoptotic function (By similarity); Belongs to the IFT57 family. (411 aa)
	pycard	Family with sequence similarity 84 member B. (199 aa)
	ccn1l	Uncharacterized protein. (238 aa)
	LOC100493406	Mediator complex subunit 15. (751 aa)
	casp2	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family. (421 aa)
	pcdhgb5l.5	Putative ortholog of protocadherin gamma B5, 5 of 5. (791 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (410 aa)
	fadd	Zinc finger, NFX1-type containing 1, gene 2. (188 aa)
	psenen	Presenilin enhancer 2 homolog (C. elegans). (101 aa)
	cradd.1	CASP2 and RIPK1 domain containing adaptor with death domain. (197 aa)
	nradd	High mobility group box 3. (390 aa)
	aifm1	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (648 aa)
	akirin2	Zinc finger and BTB domain-containing 12. (181 aa)
	rps3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (246 aa)
	psme3	Lactase like. (262 aa)
	MBP	Myelin basic protein. (297 aa)
	acvr1c	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
	PRR7	Proline rich 7, synaptic. (260 aa)
	dap	CWC22 homolog, spliceosome-associated protein. (106 aa)
	FASLG	Fas ligand. (252 aa)
	bad	SMC5-SMC6 complex localization factor 1. (151 aa)
	psme1	Proteasome (Prosome, macropain) 28 subunit, alpha. (244 aa)
	psme2	Type-1 angiotensin II receptor-associated protein-like. (248 aa)
	cideb	KIAA2013. (239 aa)
	HIP1	Huntingtin interacting protein 1. (737 aa)
	eif2ak3	Carnitine palmitoyltransferase 1A (liver) like. (929 aa)
	syk	Tyrosine-protein kinase. (611 aa)
	lyn	Tyrosine-protein kinase. (524 aa)
	PIDD1	P53-induced death domain protein 1. (908 aa)
	aph1a	Regulator of G-protein signaling 9-binding protein B. (247 aa)
	gper1	Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	lgmn	Protein phosphatase 1 regulatory subunit 9A. (433 aa)
	bok	Plexin A1. (214 aa)
	REST	RE1 silencing transcription factor. (1442 aa)
	rack1	Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1. (317 aa)
	ncstn	Cathepsin G. (592 aa)
	pcasp3	Uncharacterized protein. (632 aa)
	F3	Coagulation factor III, tissue factor. (282 aa)
	TNFSF15	TNF superfamily member 15. (236 aa)
	rock2	Mediator of RNA polymerase II transcription subunit 18; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1461 aa)
	asph	TPR_REGION domain-containing protein. (1037 aa)
	nkx3-1	Homeobox domain-containing protein. (211 aa)
	sirt1	Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	laptm5	RWD domain containing 4. (265 aa)
	ENSXETP00000051440	Uncharacterized protein. (168 aa)
	cyct	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	cidec	Cell death-inducing DFFA-like effector c. (236 aa)
	card9	Polymerase (RNA) III (DNA directed) polypeptide G (32kD). (522 aa)
	psmd14	Prokineticin receptor 2. (313 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (408 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ENSXETP00000051440	ENSXETP00000049692	ENSXETP00000051440	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.567
APAF1	FASLG	ENSXETP00000049692	ENSXETP00000035772	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas ligand.	0.606
APAF1	aifm1	ENSXETP00000049692	ENSXETP00000032430	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.543
APAF1	bax	ENSXETP00000049692	ENSXETP00000009494	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2-associated X protein.	0.752
APAF1	bcl2l11	ENSXETP00000049692	ENSXETP00000007895	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.646
APAF1	bok	ENSXETP00000049692	ENSXETP00000044504	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Plexin A1.	0.528
APAF1	casp10	ENSXETP00000049692	ENSXETP00000006082	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Casp10 protein; Belongs to the peptidase C14A family.	0.692
APAF1	casp2	ENSXETP00000049692	ENSXETP00000024754	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family.	0.748
APAF1	casp8	ENSXETP00000049692	ENSXETP00000006109	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.818
APAF1	cflar	ENSXETP00000049692	ENSXETP00000006052	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.574
APAF1	cycs	ENSXETP00000049692	ENSXETP00000002695	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.995
APAF1	cyct	ENSXETP00000049692	ENSXETP00000051640	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.995
APAF1	diablo	ENSXETP00000049692	ENSXETP00000017507	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo homolog, mitochondrial; Promotes apoptosis. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity).	0.707
APAF1	fadd	ENSXETP00000049692	ENSXETP00000025713	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Zinc finger, NFX1-type containing 1, gene 2.	0.554
APAF1	htra2	ENSXETP00000049692	ENSXETP00000011657	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Zic family member 4.	0.497
APAF1	lgmn	ENSXETP00000049692	ENSXETP00000044484	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Protein phosphatase 1 regulatory subunit 9A.	0.407
APAF1	rack1	ENSXETP00000049692	ENSXETP00000045946	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1.	0.468
APAF1	uaca	ENSXETP00000049692	ENSXETP00000012118	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cell division cycle 14B.	0.417
CASP8AP2	casp10	ENSXETP00000013124	ENSXETP00000006082	Uncharacterized protein.	Casp10 protein; Belongs to the peptidase C14A family.	0.466
CASP8AP2	casp8	ENSXETP00000013124	ENSXETP00000006109	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.466

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