(38 nodes) Potassium channel regulator activity network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (119 aa)
	kcnab1	Aldo_ket_red domain-containing protein. (429 aa)
	Lrrc38	LRRCT domain-containing protein. (287 aa)
	dpp10	Uncharacterized protein; Belongs to the peptidase S9B family. (603 aa)
	ENSXETP00000034105	Uncharacterized protein. (252 aa)
	KCNIP3	Potassium voltage-gated channel interacting protein 3. (284 aa)
	pdzd4	DnaJ heat shock protein family (Hsp40) member B5. (804 aa)
	amigo1	Adhesion molecule with Ig-like domain 1. (488 aa)
	dpp6	LOC100125080 protein; Belongs to the peptidase S9B family. (846 aa)
	LOC100496423	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	cav3.2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	WNK1	Uncharacterized protein. (2206 aa)
	AMIGO3	Adhesion molecule with Ig like domain 3. (493 aa)
	SGK3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	kcne3	Nebulin. (99 aa)
	Kcne1	Uncharacterized protein. (128 aa)
	wnk2	Guanine nucleotide binding protein (G protein), alpha 13. (1752 aa)
	kcne5	Uncharacterized protein. (103 aa)
	KCNAB2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (412 aa)
	kcns1	Cysteine-rich secretory protein 1; Belongs to the potassium channel family. (452 aa)
	wnk4	Uncharacterized protein. (691 aa)
	ywhae	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (162 aa)
	sgk1	Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response (By similarity). Plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (504 aa)
	npm2-2	Nucleophosmin/nucleoplasmin 2. (251 aa)
	LOC733765	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	ENSXETP00000022583	Uncharacterized protein. (113 aa)
	ENSXETP00000022765	Uncharacterized protein. (105 aa)
	amigo2	SPHK1 interactor, AKAP domain containing. (518 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2. (347 aa)
	atg16l1	Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. (622 aa)
	KCNIP1	Potassium voltage-gated channel interacting protein 1. (222 aa)
	cntd1	Aquaporin 9. (277 aa)
	KCNIP4	Potassium voltage-gated channel interacting protein 4. (238 aa)
	kcnmb2	KcnmB2_inactiv domain-containing protein. (235 aa)
	WNK3	Protein kinase domain-containing protein. (1624 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCNE2	KCNE4	ENSXETP00000033059	ENSXETP00000014333	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.796
KCNE2	kcne3	ENSXETP00000033059	ENSXETP00000003768	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Nebulin.	0.656
KCNE4	KCNE2	ENSXETP00000014333	ENSXETP00000033059	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.796
KCNE4	Kcne1	ENSXETP00000014333	ENSXETP00000005788	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Uncharacterized protein.	0.457
KCNE4	kcne3	ENSXETP00000014333	ENSXETP00000003768	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Nebulin.	0.606
Kcne1	KCNE4	ENSXETP00000005788	ENSXETP00000014333	Uncharacterized protein.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.457
Kcne1	kcne3	ENSXETP00000005788	ENSXETP00000003768	Uncharacterized protein.	Nebulin.	0.591
LOC733765	cav1	ENSXETP00000016352	ENSXETP00000048942	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
LOC733765	cav3.1	ENSXETP00000016352	ENSXETP00000046948	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
LOC733765	cav3.2	ENSXETP00000016352	ENSXETP00000039803	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
SGK3	sgk1	ENSXETP00000053184	ENSXETP00000014708	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response (By similarity). Plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.909
cav1	LOC733765	ENSXETP00000048942	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
cav3.1	LOC733765	ENSXETP00000046948	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
cav3.2	LOC733765	ENSXETP00000039803	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
kcne3	KCNE2	ENSXETP00000003768	ENSXETP00000033059	Nebulin.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.656
kcne3	KCNE4	ENSXETP00000003768	ENSXETP00000014333	Nebulin.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.606
kcne3	Kcne1	ENSXETP00000003768	ENSXETP00000005788	Nebulin.	Uncharacterized protein.	0.591
sgk1	SGK3	ENSXETP00000014708	ENSXETP00000053184	Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response (By similarity). Plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.909

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