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| | kremen2 | Uncharacterized protein. (421 aa) |
| | epm2a | Peptidylprolyl isomerase B. (313 aa) |
| | cthrc1 | Diacylglycerol kinase, zeta. (235 aa) |
| | csnk2b | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa) |
| | ddit3 | Potassium channel, voltage gated subfamily E regulatory beta subunit 3. (209 aa) |
| | edn1 | Nidogen 2. (222 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa) |
| | ndp | CTCK domain-containing protein. (132 aa) |
| | dvl3 | Segment polarity protein dishevelled homolog DVL-3; Involved in the signal transduction pathway mediated by multiple Wnt genes (By similarity). Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane (By similarity); Belongs to the DSH family. (713 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (361 aa) |
| | lzts2 | Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (683 aa) |
| | cxxc4 | CXXC-type zinc finger protein 4; Acts as a negative regulator of the Wnt signaling pathway required for anterior neural structure formation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). (290 aa) |
| | calcoco1 | EF-hand domain containing 2. (569 aa) |
| | lats2 | Uncharacterized protein. (1158 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (2004 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa) |
| | fzd3 | Developmentally regulated GTP binding protein 1; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa) |
| | tle5 | Transducin-like enhancer of split 4 homolog of Drosophila E(Spl). (198 aa) |
| | tle2 | tRNA methyltransferase 12 homolog. (769 aa) |
| | amer2 | APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity); Belongs to the Amer family. (566 aa) |
| | setbp1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (82 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa) |
| | ednrb | Aconitase 2; Belongs to the G-protein coupled receptor 1 family. (433 aa) |
| | sfrp5 | Secreted frizzled-related protein 5. (315 aa) |
| | apcdd1 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin (By similarity); Belongs to the APCDD1 family. (510 aa) |
| | ENSXETP00000009704 | FZ domain-containing protein. (317 aa) |
| | nphp3 | Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements (By similarity). (1266 aa) |
| | csnk2a1 | Fibronectin type III domain containing 4; Belongs to the protein kinase superfamily. (363 aa) |
| | wnt9b.2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa) |
| | wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | lef1 | HMG box domain-containing protein. (415 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa) |
| | rspo3 | Uncharacterized protein. (256 aa) |
| | szl | N-acetylgalactosaminidase, alpha-. (281 aa) |
| | LOC101731015 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | trabd2b | Metalloprotease TIKI2; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8. Required for head formation. Belongs to the TIKI family. (523 aa) |
| | MYOC | Myocilin. (499 aa) |
| | wif1 | Hypoxia inducible factor 1 subunit alpha inhibitor. (393 aa) |
| | dixdc1 | VRK serine/threonine kinase 1. (693 aa) |
| | wnt4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | DAB2 | DAB adaptor protein 2. (820 aa) |
| | PYGO1 | Pygopus family PHD finger 1. (506 aa) |
| | brd7 | Bromo domain-containing protein. (644 aa) |
| | ryk | Uncharacterized protein. (601 aa) |
| | pkd1 | L-threonine dehydrogenase (pseudogene). (4091 aa) |
| | nkd1 | EF-hand domain-containing protein. (453 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa) |
| | apc | Zinc finger DHHC-type containing 1. (2833 aa) |
| | pax3 | Paired box protein Pax-3; Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1 (By similarity); Belongs to the paired homeobox family. (486 aa) |
| | LOC733765 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa) |
| | znrf3 | E3 ubiquitin-protein ligase ZNRF3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification. (868 aa) |
| | kremen1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (453 aa) |
| | cep112 | Adenosine monophosphate deaminase 2. (310 aa) |
| | fzd6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (295 aa) |
| | gsk3a | CACN subunit beta associated regulatory protein; Belongs to the protein kinase superfamily. (439 aa) |
| | lrp5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa) |
| | BCL9L | BCL9 like. (1282 aa) |
| | axin1 | P21 protein (Cdc42/Rac)-activated kinase 3. (877 aa) |
| | wnt11-2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N- terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not requ [...] (352 aa) |
| | fzd1 | FZ domain-containing protein. (197 aa) |
| | cdk14 | Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway (By similarity). (469 aa) |
| | wnt10b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa) |
| | ENSXETP00000021784 | DIX domain-containing protein. (192 aa) |
| | csnk2a2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (349 aa) |
| | nxn | Thioredoxin domain-containing protein. (414 aa) |
| | wnt7b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (285 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa) |
| | apc2 | Transmembrane protein 11. (2325 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa) |
| | rspo2 | R-spondin-2; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, su [...] (243 aa) |
| | BARX1 | BARX homeobox 1. (252 aa) |
| | jup | Uncharacterized protein. (750 aa) |
| | ccdc90b | Coiled-coil domain-containing protein 90B, mitochondrial. (287 aa) |
| | lgr4 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (956 aa) |
| | KLHL12 | Kelch like family member 12. (599 aa) |
| | csnk1g1 | Zinc finger protein 605. (461 aa) |
| | nlk.2 | Serine/threonine-protein kinase NLK2. (336 aa) |
| | bcl7b | LOC100125186 protein. (189 aa) |
| | rnf43 | E3 ubiquitin-protein ligase RNF43; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. (689 aa) |
| | ska1-2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa) |
| | LOC100489307 | Dynein, axonemal, heavy chain 2; Belongs to the peptidase C19 family. (757 aa) |
| | CELSR1 | Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2981 aa) |
| | lrrc45 | Parathyroid hormone 2 receptor. (707 aa) |
| | wt1 | Wilms tumor protein homolog; Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule- specific gene expression in the portion of the pronephros fated to form the glomus (By similarity). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Inhibits Wnt-signaling during embryonic development (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (452 aa) |
| | dvl2 | Segment polarity protein dishevelled homolog DVL-2; Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta- catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin- related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along [...] (316 aa) |
| | siah1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa) |
| | csnk1d | Casein kinase I isoform delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (441 aa) |
| | LOC100495217 | UTP14A, small subunit processome component. (263 aa) |
| | fzd5 | Zinc finger DHHC-type containing 9; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa) |
| | frat1 | Uncharacterized protein. (165 aa) |
| | dvl1 | Uncharacterized protein. (707 aa) |
| | trabd2a | Metalloprotease TIKI1; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway: expressed in the Spemann-Mangold organizer and is required for anterior-neural patterning in head formation in embryos. Acts by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8; Belongs to the TIKI family. (509 aa) |
| | cpe | Uncharacterized protein. (467 aa) |
| | fzd8 | Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) |
| | dkk1 | Dickkopf 1. (257 aa) |
| | rnf138 | Uncharacterized protein. (222 aa) |
| | mms19 | MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). (1048 aa) |
| | chd8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity. Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive [...] (2206 aa) |
| | BCL9 | BCL9 transcription coactivator. (1475 aa) |
| | gid8 | Uncharacterized protein. (228 aa) |
| | rnf146 | E3 ubiquitin-protein ligase rnf146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair. (316 aa) |
| | cyb5r3-2 | Cytochrome b5 reductase 3. (278 aa) |
| | tcf7l2 | RNA binding motif protein 18. (572 aa) |
| | wnt8a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | ccne1 | Cyclin E1; Belongs to the cyclin family. (408 aa) |
| | hhex | Hematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Probably plays a role in the proliferation of vascular endothelial cells during blood vessel development. Establishes anterior identity at two levels; acts early to enhance canonical wnt-signaling by repressing expression of tle4, and acts later to inhibit nodal- signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a role in liver development. Induces heart development (By similarity). (274 aa) |
| | porcn | Axin interactor, dorsalization associated; Belongs to the membrane-bound acyltransferase family. (259 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1129 aa) |
| | VAX2 | Ventral anterior homeobox 2. (299 aa) |
| | LOC100487954 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | csnk1g2 | 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic; Belongs to the protein kinase superfamily. (412 aa) |
| | celsr2 | Immunoglobin superfamily member 21; Belongs to the G-protein coupled receptor 2 family. (2911 aa) |
| | wwox | RUNX family transcription factor 1. (381 aa) |
| | ift80 | Intraflagellar transport 80 homolog. (779 aa) |
| | tax1bp3 | PDZ domain-containing protein. (181 aa) |
| | wnt11b | Protein Wnt-11b-2; Ligand for the frizzled7 transmembrane receptor. Primarily acts via non-canonical Wnt pathways mediated by either Ca(2+) and PKC, or by JNK and dvl2/dsh. Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh. May also inhibit canonical Wnt signaling. Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6. In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation. In the non- canonical pathway, acts through fzd7/fz7 to [...] (353 aa) |
| | tnks | Poly [ADP-ribose] polymerase. (1306 aa) |
| | AMOTL2 | Angiomotin like 2. (717 aa) |
| | pkd2 | Ubiquitin carboxyl-terminal hydrolase 33. (951 aa) |
| | prkaa1 | Non-specific serine/threonine protein kinase. (571 aa) |
| | ror2 | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa) |
| | tcf7 | HMG box domain-containing protein. (488 aa) |
| | c1h12orf43 | ELMO/CED-12 domain containing 3. (243 aa) |
| | sox17a | Transcription factor Sox-17-alpha; Transcription activator. Binds to the DNA sequence 5'-AACAAT- 3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling (By similarity). (383 aa) |
| | celsr3 | Bone morphogenetic protein/retinoic acid inducible neural-specific 1; Belongs to the G-protein coupled receptor 2 family. (3713 aa) |
| | cav3.2 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa) |
| | ubac2 | Enoyl-CoA hydratase 1, peroxisomal. (367 aa) |
| | ccdc88c | Zinc finger protein 668. (2033 aa) |
| | hmgxb4 | HMG box-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development. (554 aa) |
| | zranb1 | Ubiquitin thioesterase zranb1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). (729 aa) |
| | RECK | Reversion inducing cysteine rich protein with kazal motifs. (983 aa) |
| | frzb2 | Frzb2 protein. (300 aa) |
| | sox10 | Transcription factor Sox-10; Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox9 to induce neural crest progenitors. Acts downstream of wnt-signaling at the neural plate border. Involved in the specification of neural crest progenitors fated to form the pigment cell lineage (By similarity). (436 aa) |
| | ednrb2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa) |
| | DRAXIN | Dorsal inhibitory axon guidance protein. (339 aa) |
| | csnk1e | DEAD-box helicase 24. (516 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (966 aa) |
| | csnk1a1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (353 aa) |
| | ctnnb1 | Dynactin subunit 5. (788 aa) |
| | ednra | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (414 aa) |
| | ndrg2 | Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation (By similarity). Belongs to the NDRG family. (360 aa) |
| | cer1 | Cerberus short; Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction. Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm (By similarity). (187 aa) |
| | siah2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (318 aa) |
| | wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | dact1 | Dapper 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and regulates the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. May also bind to and directly stimulate the activity of tcf7l1 (By similarity); Belongs to the dapper family. (875 aa) |
| | wnt9b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa) |
| | usp34 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Belongs to the peptidase C19 family. (3543 aa) |
| | gata3 | Uncharacterized protein. (454 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa) |
| | tle4 | F-box and WD repeat domain containing 4. (774 aa) |
| | cpz | FZ domain-containing protein. (662 aa) |
| | hbp1 | TNF alpha induced protein 8 like 3. (541 aa) |
| | vangl2 | Vang-like protein 2; Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruite dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates convergent extension in both dorsal mesoderm and neural tissue without affecting cell fate. Regulates neural fold closure during neurulation. May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity). (521 aa) |
| | invs | ANK_REP_REGION domain-containing protein. (1004 aa) |
| | tle1 | Uncharacterized protein. (780 aa) |
| | xiap | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling. Belongs to the IAP family. (492 aa) |
| | frzb | Small G protein signaling modulator 1. (319 aa) |
| | cav3.1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa) |
| | MESD | Mesoderm development LRP chaperone. (212 aa) |
| | sostdc1 | Transmembrane protein 52. (213 aa) |
| | gsc | Homeobox domain-containing protein. (275 aa) |
| | csnk1g3 | Sin3A associated protein 30kDa; Belongs to the protein kinase superfamily. (456 aa) |
| | agbl5 | Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains. (944 aa) |
| | fzd2 | Neurotrophic receptor tyrosine kinase 1; Belongs to the G-protein coupled receptor Fz/Smo family. (553 aa) |
| | plpp3 | Ppap2b protein. (307 aa) |
| | prkaa2 | Non-specific serine/threonine protein kinase. (564 aa) |
| | mettl23 | Methyltransferase like 23. (175 aa) |
| | cav1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa) |
| | dkk3 | Ankyrin repeat and SOCS box containing 4. (336 aa) |
| | cyld | TLR4 interactor with leucine-rich repeats; Belongs to the peptidase C19 family. (975 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | wls | Uncharacterized protein. (541 aa) |
| | wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (402 aa) |
| | sfrp1 | Uncharacterized protein. (304 aa) |
| | scyl2 | GATA zinc finger domain containing 2B. (930 aa) |
| | tcf7l1 | Transcription factor 7-like 1; Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of ctnnb1, and as an activator in its presence. Required early in development for the establishment of the dorsal body axis in response to maternal Wnt signaling (By similarity); Belongs to the TCF/LEF family. (567 aa) |
| | sia1 | Homeobox protein siamois; Essential for Wnt/beta-catenin-mediated formation of the Spemann organizer and for induction of the organizer precursor, the Nieuwkoop center. Acts as a transcriptional activator, cooperating with TGFbeta signals to induce a program of organizer-specific gene expression and to generate an organizer with both head- and trunk- inducing activity. Activates the head organizer gene cer1 by acting synergistically with otx2 and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and mix-A/mix.1 to the 3x 5'-TAAT-3 [...] (240 aa) |
| | wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa) |
| | wnt5b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa) |
| | wnt10a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | fzd7 | Frizzled-7; Receptor for Wnt proteins. Acts in both canonical and non- canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension movements in gastrulation. Triggers phosphorylation [...] (548 aa) |
| | LRRFIP1 | Leucine-rich repeat flightless-interacting protein 2; May function as an activator of the canonical Wnt signaling pathway upstream of ctnnb1/beta-catenin. May be required for dorsal axis formation (By similarity). (687 aa) |
| | LEO1 | LEO1 homolog, Paf1/RNA polymerase II complex component. (718 aa) |
| | tmem198 | Transmembrane protein 198; Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation. (354 aa) |
| | rtf1 | Plus3 domain-containing protein. (675 aa) |
| | nlk | Serine/threonine-protein kinase NLK2; Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 to phosphorylate stat3. Augments the rnf138/narf-directed ubiquitination and degradation of tcf/lef by enhancing the association of rnf138/narf and tcf/lef. Phosphorylates mef2a to play a role in anterior neural development, including eye formation (By similarity). (534 aa) |
| | rspo1 | Uncharacterized protein. (257 aa) |
