(30 nodes) Lateral plasma membrane network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC26A5	Solute carrier family 26 member 5. (803 aa)
	LOC101735095	EGF containing fibulin extracellular matrix protein 1. (221 aa)
	arl2	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	fzd3	Developmentally regulated GTP binding protein 1; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	ptpro	ORMDL sphingolipid biosynthesis regulator 1. (1018 aa)
	as3mt.1-2	Arsenite methyltransferase, gene 1. (613 aa)
	fam168b	Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Belongs to the FAM168 family. (226 aa)
	kcnq1	KRI1 homolog; Belongs to the potassium channel family. (659 aa)
	anxa1.3	Annexin. (350 aa)
	bves	Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. May play a role in vamp3-mediated vesicular transport and recycling of different receptor molecules. May be involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. May be involved in epithelial movement during corneal sheet formation and regeneration. May play a role in the regulation of cel [...] (344 aa)
	pkd1	L-threonine dehydrogenase (pseudogene). (4091 aa)
	C1QTNF5	C1q and TNF related 5. (248 aa)
	slc16a3	Solute carrier family 16, member 3 (Monocarboxylic acid transporter 4). (473 aa)
	nsg1	DDB1- and CUL4-associated factor 13. (185 aa)
	tbcd	MIS12 kinetochore complex component. (1187 aa)
	cldn4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	gjb1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (264 aa)
	anxa1.1	Annexin. (675 aa)
	bsg	Solute carrier family 25 member 13. (410 aa)
	cldn12	Histidyl-tRNA synthetase. (245 aa)
	ENSXETP00000034825	Uncharacterized protein. (666 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	myo1c	Nucleolar protein 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1075 aa)
	cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	erlin2	Erlin-2; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity); Belongs to the band 7/mec-2 family. (357 aa)
	epcam	Epithelial cell adhesion molecule. (312 aa)
	ctnnb1	Dynactin subunit 5. (788 aa)
	LOC100492908	Uncharacterized protein; Belongs to the potassium channel family. (687 aa)
	akap7	Uncharacterized protein. (566 aa)
	lepr	Leucine-rich repeat-containing protein 42. (1138 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101735095	ctnnb1	ENSXETP00000002141	ENSXETP00000043290	EGF containing fibulin extracellular matrix protein 1.	Dynactin subunit 5.	0.409
arl2	tbcd	ENSXETP00000002845	ENSXETP00000027130	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	MIS12 kinetochore complex component.	0.966
cldn1	cldn12	ENSXETP00000041877	ENSXETP00000033485	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Histidyl-tRNA synthetase.	0.599
cldn1	cldn4	ENSXETP00000041877	ENSXETP00000029923	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.780
cldn1	cldn5	ENSXETP00000041877	ENSXETP00000039447	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.744
cldn1	ctnnb1	ENSXETP00000041877	ENSXETP00000043290	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Dynactin subunit 5.	0.594
cldn12	cldn1	ENSXETP00000033485	ENSXETP00000041877	Histidyl-tRNA synthetase.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.599
cldn12	cldn4	ENSXETP00000033485	ENSXETP00000029923	Histidyl-tRNA synthetase.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.556
cldn12	cldn5	ENSXETP00000033485	ENSXETP00000039447	Histidyl-tRNA synthetase.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.593
cldn4	cldn1	ENSXETP00000029923	ENSXETP00000041877	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.780
cldn4	cldn12	ENSXETP00000029923	ENSXETP00000033485	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Histidyl-tRNA synthetase.	0.556
cldn4	cldn5	ENSXETP00000029923	ENSXETP00000039447	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.776
cldn4	epcam	ENSXETP00000029923	ENSXETP00000043199	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Epithelial cell adhesion molecule.	0.429
cldn5	cldn1	ENSXETP00000039447	ENSXETP00000041877	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.744
cldn5	cldn12	ENSXETP00000039447	ENSXETP00000033485	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Histidyl-tRNA synthetase.	0.593
cldn5	cldn4	ENSXETP00000039447	ENSXETP00000029923	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.776
ctnnb1	LOC101735095	ENSXETP00000043290	ENSXETP00000002141	Dynactin subunit 5.	EGF containing fibulin extracellular matrix protein 1.	0.409
ctnnb1	cldn1	ENSXETP00000043290	ENSXETP00000041877	Dynactin subunit 5.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.594
ctnnb1	gjb1	ENSXETP00000043290	ENSXETP00000030926	Dynactin subunit 5.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.409
epcam	cldn4	ENSXETP00000043199	ENSXETP00000029923	Epithelial cell adhesion molecule.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.429

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