(134 nodes) Protein processing network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RIPK2	Receptor interacting serine/threonine kinase 2. (408 aa)
	LOC100497588	Uncharacterized protein; Belongs to the peptidase S1 family. (829 aa)
	ENSXETP00000000456	Uncharacterized protein. (198 aa)
	mtor-2	Mechanistic target of rapamycin kinase; Belongs to the peptidase S1 family. (458 aa)
	ddi2	Protein DDI1 homolog 2; Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required for cellular survival following replication stress. (348 aa)
	afg3l1p	Fucosyltransferase 1 (H blood group). (785 aa)
	vsir	Hypothetical LOC496981. (289 aa)
	immp1l	Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. (167 aa)
	spg7	Tetraspanin 31. (768 aa)
	arl1-2	SprT-like domain-containing protein. (248 aa)
	ENSXETP00000005412	SprT-like domain-containing protein. (263 aa)
	GLG1	Golgi glycoprotein 1. (1148 aa)
	casp10	Casp10 protein; Belongs to the peptidase C14A family. (519 aa)
	casp8	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
	tmprss4	FKBP prolyl isomerase 14; Belongs to the peptidase S1 family. (808 aa)
	lonp2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (845 aa)
	cyfip2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1266 aa)
	pitrm1	Presequence protease, mitochondrial; Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides; Belongs to the peptidase M16 family. PreP subfamily. (1029 aa)
	MME	Membrane metalloendopeptidase. (620 aa)
	pisd	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (355 aa)
	rce1	RCE1 homolog, prenyl protein peptidase (S. cerevisiae). (308 aa)
	LOC100485347	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (345 aa)
	ENSXETP00000011099	Uncharacterized protein. (197 aa)
	spcs1	Mitochondrial ribosomal protein L44. (113 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (558 aa)
	LOC100490828	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (559 aa)
	corin	Arginyl aminopeptidase (aminopeptidase B). (1123 aa)
	DISP1	Dispatched RND transporter family member 1. (1241 aa)
	spcs3	Signal peptidase complex subunit 3. (180 aa)
	HJV	Hemojuvelin BMP co-receptor. (402 aa)
	dmgdh-2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (226 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
	furin	Receptor expression-enhancing protein 4; Belongs to the peptidase S8 family. (789 aa)
	tpm3	Tropomyosin 3. (197 aa)
	metap1	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (385 aa)
	ace	Angiotensin-converting enzyme. (1337 aa)
	il1r2	GATA binding protein 6. (349 aa)
	stoml2	PHB domain-containing protein. (341 aa)
	tll2	Metalloendopeptidase. (1021 aa)
	syt17	Synaptotagmin-17; May play a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family. (474 aa)
	pcsk6	Ganglioside induced differentiation associated protein 1-like 1; Belongs to the peptidase S8 family. (932 aa)
	mep1a	Uncharacterized protein. (604 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	casp7	Leucine rich repeat containing 38; Belongs to the peptidase C14A family. (294 aa)
	fgb	Fibrinogen C-terminal domain-containing protein. (496 aa)
	FGG	Fibrinogen gamma chain. (438 aa)
	fkrp	Uncharacterized protein. (538 aa)
	ece2	Dehydrodolichyl diphosphate synthase subunit. (766 aa)
	c1r	Kelch like family member 8; Belongs to the peptidase S1 family. (714 aa)
	LOC100485749	Uncharacterized protein; Belongs to the peptidase S1 family. (724 aa)
	bmp1	Metalloendopeptidase. (983 aa)
	pcsk4	Corticotropin releasing hormone receptor 1, gene 2; Belongs to the peptidase S8 family. (794 aa)
	LOC105948375	SprT-like domain-containing protein. (233 aa)
	pycard	Family with sequence similarity 84 member B. (199 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (451 aa)
	casp2	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family. (421 aa)
	MIPEP	Mitochondrial intermediate peptidase. (715 aa)
	gli3	Centrosomal protein 164kDa. (1566 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1786 aa)
	fadd	Zinc finger, NFX1-type containing 1, gene 2. (188 aa)
	adam10	DnaJ heat shock protein family (Hsp40) member C24. (760 aa)
	pcsk1	Zygote arrest 1; Belongs to the peptidase S8 family. (749 aa)
	psenen	Presenilin enhancer 2 homolog (C. elegans). (101 aa)
	cln5	Fibroblast growth factor 7. (333 aa)
	LOC105948377	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (199 aa)
	xpnpep3	Novel metallopeptidase family M24 protein. (502 aa)
	parl	Rhomboid domain-containing protein. (364 aa)
	pcsk2	Pcsk2 protein; Belongs to the peptidase S8 family. (639 aa)
	adam19	TBC1 domain family member 32. (911 aa)
	atp23	Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. (235 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
	cpe	Uncharacterized protein. (467 aa)
	MYRFL	Myelin regulatory factor like. (625 aa)
	tll1-2	Metalloendopeptidase. (948 aa)
	mmp14	ZnMc domain-containing protein. (622 aa)
	bace1	Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family. (502 aa)
	spon1	Uncharacterized protein. (809 aa)
	prss12	Transmembrane protein 132A; Belongs to the peptidase S1 family. (851 aa)
	PCSK7	Proprotein convertase subtilisin/kexin type 7. (760 aa)
	cpm	Uncharacterized protein. (461 aa)
	oma1	Transmembrane protein 19. (485 aa)
	tmem208	LOC100145260 protein. (174 aa)
	LOC100487533	Ubiquilin 1; Belongs to the peptidase S1 family. (275 aa)
	ENSXETP00000033019	Uncharacterized protein. (134 aa)
	spcs2	Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP). (63 aa)
	ENSXETP00000033037	Uncharacterized protein. (63 aa)
	casp6	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (304 aa)
	ece1	RHO family-interacting cell polarization regulator 1. (384 aa)
	ogt	Enolase 4. (1073 aa)
	calb1-2	Metalloendopeptidase. (207 aa)
	MYRF	Myelin regulatory factor. (1142 aa)
	f12	Calcitonin gene-related peptide type 1 receptor; Belongs to the peptidase S1 family. (585 aa)
	LOC101732407.1	SprT-like domain-containing protein. (190 aa)
	twsg2	Twisted gastrulation homolog 2. (244 aa)
	afg3l2	Uncharacterized protein. (808 aa)
	bad	SMC5-SMC6 complex localization factor 1. (151 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (404 aa)
	cideb	KIAA2013. (239 aa)
	metap2	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (483 aa)
	HGFAC	HGF activator. (634 aa)
	bace2	Gastrin; Belongs to the peptidase A1 family. (504 aa)
	sppl3	Signal peptide peptidase 3. (410 aa)
	adam17	Monooxygenase, DBH-like 2, pseudogene. (834 aa)
	thdl18-2	Uncharacterized protein. (44 aa)
	cpn1	Carboxypeptidase N, polypeptide 1, 50 kD. (449 aa)
	tysnd1	Serine protease; Belongs to the peptidase S1B family. (588 aa)
	pisd-2	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (413 aa)
	mmel1	Uncharacterized protein. (768 aa)
	PIDD1	P53-induced death domain protein 1. (908 aa)
	mbtps1	Inositol polyphosphate phosphatase-like 1. (1061 aa)
	TEX26	Testis expressed 26. (351 aa)
	aph1a	Regulator of G-protein signaling 9-binding protein B. (247 aa)
	plat	Plasminogen activator; Belongs to the peptidase S1 family. (560 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4246 aa)
	dhcr24	FAD-binding PCMH-type domain-containing protein. (518 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (684 aa)
	ECEL1	Endothelin converting enzyme like 1. (764 aa)
	lgmn	Protein phosphatase 1 regulatory subunit 9A. (433 aa)
	cpz	FZ domain-containing protein. (662 aa)
	ncstn	Cathepsin G. (592 aa)
	ptpmt1	Protein tyrosine phosphatase, mitochondrial 1. (270 aa)
	yme1l1	Glycogen synthase 1. (742 aa)
	F3	Coagulation factor III, tissue factor. (282 aa)
	PHEX	Phosphate regulating endopeptidase homolog X-linked. (733 aa)
	asph	TPR_REGION domain-containing protein. (1037 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	sprtn	SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated pcna; Belongs to the Spartan family. (436 aa)
	PTCH1	Patched 1. (1430 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	cntn2	Polymerase (RNA) II subunit I. (1013 aa)
	ENSXETP00000051440	Uncharacterized protein. (168 aa)
	cidec	Cell death-inducing DFFA-like effector c. (236 aa)
	PMPCA	Peptidase, mitochondrial processing alpha subunit. (520 aa)
	FXN	Frataxin. (206 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ENSXETP00000051440	ENSXETP00000049692	ENSXETP00000051440	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.567
APAF1	casp10	ENSXETP00000049692	ENSXETP00000006082	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Casp10 protein; Belongs to the peptidase C14A family.	0.692
APAF1	casp2	ENSXETP00000049692	ENSXETP00000024754	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family.	0.748
APAF1	casp6	ENSXETP00000049692	ENSXETP00000033795	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.685
APAF1	casp7	ENSXETP00000049692	ENSXETP00000019233	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Leucine rich repeat containing 38; Belongs to the peptidase C14A family.	0.750
APAF1	casp8	ENSXETP00000049692	ENSXETP00000006109	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.818
APAF1	fadd	ENSXETP00000049692	ENSXETP00000025713	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Zinc finger, NFX1-type containing 1, gene 2.	0.554
APAF1	lgmn	ENSXETP00000049692	ENSXETP00000044484	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Protein phosphatase 1 regulatory subunit 9A.	0.407
DISP1	IHH	ENSXETP00000013743	ENSXETP00000050990	Dispatched RND transporter family member 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.829
DISP1	PTCH1	ENSXETP00000013743	ENSXETP00000050385	Dispatched RND transporter family member 1.	Patched 1.	0.495
DISP1	dhh	ENSXETP00000013743	ENSXETP00000018756	Dispatched RND transporter family member 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.829
DISP1	shh	ENSXETP00000013743	ENSXETP00000036680	Dispatched RND transporter family member 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.829
ENSXETP00000033019	immp1l	ENSXETP00000033019	ENSXETP00000004662	Uncharacterized protein.	Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.	0.461
ENSXETP00000033019	spcs1	ENSXETP00000033019	ENSXETP00000012152	Uncharacterized protein.	Mitochondrial ribosomal protein L44.	0.859
ENSXETP00000033019	spcs3	ENSXETP00000033019	ENSXETP00000013865	Uncharacterized protein.	Signal peptidase complex subunit 3.	0.856
ENSXETP00000033019	thdl18-2	ENSXETP00000033019	ENSXETP00000039891	Uncharacterized protein.	Uncharacterized protein.	0.461
ENSXETP00000033037	immp1l	ENSXETP00000033037	ENSXETP00000004662	Uncharacterized protein.	Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.	0.461
ENSXETP00000033037	spcs1	ENSXETP00000033037	ENSXETP00000012152	Uncharacterized protein.	Mitochondrial ribosomal protein L44.	0.859
ENSXETP00000033037	spcs3	ENSXETP00000033037	ENSXETP00000013865	Uncharacterized protein.	Signal peptidase complex subunit 3.	0.856
ENSXETP00000033037	thdl18-2	ENSXETP00000033037	ENSXETP00000039891	Uncharacterized protein.	Uncharacterized protein.	0.461

page 1 of 16

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About