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mpc2-2 mpc2-2 nme3 nme3 nme2 nme2 casc3 casc3 ak8 ak8 guk1 guk1 nme5 nme5 cmpk1 cmpk1 ak5 ak5 cmpk2 cmpk2 LOC100491113 LOC100491113 PPIP5K1 PPIP5K1 ITPKB ITPKB cblb cblb nme7 nme7 itpkc itpkc ak2 ak2 ENSXETP00000027777 ENSXETP00000027777 ak1 ak1 AK9 AK9 nme6 nme6 ip6k2 ip6k2 PPIP5K2 PPIP5K2 ak6 ak6 dtymk dtymk AK4 AK4 ak7 ak7 itpka itpka ip6k1 ip6k1 ak3 ak3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mpc2-2Deoxycytidine kinase, gene 2. (477 aa)
nme3SRY-box 8; Belongs to the NDK family. (188 aa)
nme2Nucleoside diphosphate kinase. (204 aa)
casc3Protein CASC3; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs th [...] (717 aa)
ak8Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. (485 aa)
guk1EF-hand calcium-binding domain 7. (233 aa)
nme5NDK domain-containing protein; Belongs to the NDK family. (222 aa)
cmpk1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (219 aa)
ak5Uncharacterized protein; Belongs to the adenylate kinase family. (557 aa)
cmpk2Tripartite motif containing 2. (459 aa)
LOC100491113Kinase; Belongs to the inositol phosphokinase (IPK) family. (368 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1361 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (655 aa)
cblbE3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (982 aa)
nme7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (379 aa)
itpkcKinase; Belongs to the inositol phosphokinase (IPK) family. (518 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (235 aa)
ENSXETP00000027777FRAS1 related extracellular matrix 1b. (137 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (502 aa)
AK9Adenylate kinase 9. (1609 aa)
nme6Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (179 aa)
ip6k2Kinase; Belongs to the inositol phosphokinase (IPK) family. (429 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1257 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (171 aa)
dtymkDeoxythymidylate kinase (Thymidylate kinase). (216 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (231 aa)
ak7Adenylate kinase 7. (710 aa)
itpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (470 aa)
ip6k1Kinase; Belongs to the inositol phosphokinase (IPK) family. (412 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (221 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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