(76 nodes) SH3 domain binding network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	elmo3	Myocardin related transcription factor B. (695 aa)
	inpp5j	Calcium channel, voltage-dependent, T type, alpha 1I subunit. (767 aa)
	errfi1	CD53 molecule. (404 aa)
	sh3bp1	Uncharacterized protein. (636 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1900 aa)
	efs	Embryonal Fyn-associated substrate. (749 aa)
	cblc	Uncharacterized protein. (425 aa)
	RAD9B	RAD9 checkpoint clamp component B. (307 aa)
	adam17	Monooxygenase, DBH-like 2, pseudogene. (834 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1850 aa)
	LOC100498440	Actinin alpha 4. (202 aa)
	KHDRBS3	KH RNA binding domain containing, signal transduction associated 3. (342 aa)
	vasp	Neuraminidase 1 (lysosomal sialidase). (365 aa)
	lyn	Tyrosine-protein kinase. (524 aa)
	qki	SPRY domain-containing SOCS box protein 3. (381 aa)
	AFAP1L1	Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. (757 aa)
	lancl1	LanC lantibiotic synthetase component C-like 1 (Bacterial). (402 aa)
	bcar1	SH3 domain-containing protein. (951 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (414 aa)
	cyba	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (187 aa)
	evl	Solute carrier family 30 (zinc transporter), member 9. (712 aa)
	dnajc6	Uncharacterized protein. (946 aa)
	abi1	Uncharacterized protein. (502 aa)
	mvb12a	Uncharacterized protein. (418 aa)
	sgip1	Semaphorin 5B. (734 aa)
	enkur	Solute carrier family 15 member 2. (265 aa)
	znf106	WD_REPEATS_REGION domain-containing protein. (1804 aa)
	dennd1a	Tec protein tyrosine kinase. (904 aa)
	abi2	Uncharacterized protein. (544 aa)
	sh3bp5	Proline-rich 14-like. (437 aa)
	AFAP1L2	Actin filament associated protein 1 like 2. (712 aa)
	hip1r	Uncharacterized protein. (1066 aa)
	shank2	Uncharacterized protein. (1829 aa)
	uvrag	Sorting nexin 10. (698 aa)
	abi3	Abi_HHR domain-containing protein. (337 aa)
	ptpn12	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (709 aa)
	ENSXETP00000053351	DUF3361 domain-containing protein. (231 aa)
	khdrbs1	Phosducin. (377 aa)
	sh3d21	Synovial sarcoma, X breakpoint 2 interacting protein. (552 aa)
	tom1l1	Uncharacterized protein; Belongs to the TOM1 family. (477 aa)
	rufy1	Family with sequence similarity 43 member B. (606 aa)
	ELMO1	Engulfment and cell motility 1. (740 aa)
	fut8	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (578 aa)
	ncf1	Ncf1 protein. (391 aa)
	itgb1bp2	Lymphoid-restricted membrane protein-like. (375 aa)
	reps1	Uncharacterized protein. (601 aa)
	wipf1	Uncharacterized protein. (446 aa)
	sh3bgr	Uncharacterized protein. (178 aa)
	crk	Multivesicular body subunit 12B. (297 aa)
	SH3BGRL	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (117 aa)
	Prrt2	Membrane associated ring-CH-type finger 4. (74 aa)
	cbl	Uncharacterized protein. (954 aa)
	sos1	Organic solute transporter subunit alpha. (1329 aa)
	sh3kbp1	Transmembrane serine protease 9. (683 aa)
	ptprk-2	Protein tyrosine phosphatase receptor type K. (165 aa)
	sh3bp2	SH2 domain-containing protein. (412 aa)
	synj2	Scavenger receptor class B member 1. (1551 aa)
	batf	Basic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells; Belongs to the bZIP family. (115 aa)
	ptpn6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
	enah	Sorbin and SH3 domain containing 2. (799 aa)
	cd2ap	Leucine rich repeat containing 10. (717 aa)
	espn	Uncharacterized protein. (1349 aa)
	afap1	Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa. (823 aa)
	cblb	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (982 aa)
	elmo2	ELMO domain-containing protein. (732 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (379 aa)
	WIPF3	WAS/WASL interacting protein family member 3. (424 aa)
	synj1	Stathmin 3. (1548 aa)
	adam10	DnaJ heat shock protein family (Hsp40) member C24. (760 aa)
	pdik1l	PDLIM1 interacting kinase 1 like. (153 aa)
	wasf2	Forkhead box Q1. (484 aa)
	ENSXETP00000028394	ATPase family AAA domain-containing protein 3. (324 aa)
	adam19	TBC1 domain family member 32. (911 aa)
	sh3bgrl2	SH3 domain-binding glutamic acid-rich-like protein 2. (106 aa)
	rufy2	Factor interacting with PAPOLA and CPSF1. (457 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (925 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELMO1	elmo2	ENSXETP00000008707	ENSXETP00000023172	Engulfment and cell motility 1.	ELMO domain-containing protein.	0.901
INPPL1	bcar1	ENSXETP00000033120	ENSXETP00000043234	Inositol polyphosphate phosphatase like 1.	SH3 domain-containing protein.	0.520
INPPL1	cbl	ENSXETP00000033120	ENSXETP00000014969	Inositol polyphosphate phosphatase like 1.	Uncharacterized protein.	0.486
INPPL1	cblb	ENSXETP00000033120	ENSXETP00000022441	Inositol polyphosphate phosphatase like 1.	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.	0.486
INPPL1	cblc	ENSXETP00000033120	ENSXETP00000036221	Inositol polyphosphate phosphatase like 1.	Uncharacterized protein.	0.486
KHDRBS3	khdrbs1	ENSXETP00000040148	ENSXETP00000053615	KH RNA binding domain containing, signal transduction associated 3.	Phosducin.	0.462
Prrt2	synj2	ENSXETP00000014854	ENSXETP00000016639	Membrane associated ring-CH-type finger 4.	Scavenger receptor class B member 1.	0.414
RAD9B	rad9a	ENSXETP00000037398	ENSXETP00000023767	RAD9 checkpoint clamp component B.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.909
SHANK1	SHANK3	ENSXETP00000035860	ENSXETP00000039894	SH3 and multiple ankyrin repeat domains 1.	SH3 and multiple ankyrin repeat domains 3.	0.547
SHANK3	SHANK1	ENSXETP00000039894	ENSXETP00000035860	SH3 and multiple ankyrin repeat domains 3.	SH3 and multiple ankyrin repeat domains 1.	0.547
SHANK3	abi1	ENSXETP00000039894	ENSXETP00000047708	SH3 and multiple ankyrin repeat domains 3.	Uncharacterized protein.	0.523
SHANK3	shank2	ENSXETP00000039894	ENSXETP00000001228	SH3 and multiple ankyrin repeat domains 3.	Uncharacterized protein.	0.435
WIPF3	hip1r	ENSXETP00000024345	ENSXETP00000002040	WAS/WASL interacting protein family member 3.	Uncharacterized protein.	0.539
WIPF3	wipf1	ENSXETP00000024345	ENSXETP00000012061	WAS/WASL interacting protein family member 3.	Uncharacterized protein.	0.900
abi1	SHANK3	ENSXETP00000047708	ENSXETP00000039894	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 3.	0.523
abi1	enah	ENSXETP00000047708	ENSXETP00000018630	Uncharacterized protein.	Sorbin and SH3 domain containing 2.	0.450
abi1	sos1	ENSXETP00000047708	ENSXETP00000015522	Uncharacterized protein.	Organic solute transporter subunit alpha.	0.778
abi1	vasp	ENSXETP00000047708	ENSXETP00000040159	Uncharacterized protein.	Neuraminidase 1 (lysosomal sialidase).	0.511
abi1	wasf2	ENSXETP00000047708	ENSXETP00000028240	Uncharacterized protein.	Forkhead box Q1.	0.935
abi2	enah	ENSXETP00000004574	ENSXETP00000018630	Uncharacterized protein.	Sorbin and SH3 domain containing 2.	0.504

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