STRINGSTRING
ep300 ep300 msl1 msl1 pax6 pax6 dhx58-2 dhx58-2 taf5 taf5 PHF20 PHF20 trim16 trim16 kat8 kat8 kansl1 kansl1 kansl2 kansl2 naa60 naa60 ruvbl2 ruvbl2 hat1 hat1 yeats4 yeats4 sgf29 sgf29 lef1 lef1 mllt3 mllt3 TAF6 TAF6 naa40 naa40 BEND3 BEND3 jade1 jade1 SMC5 SMC5 mecp2 mecp2 LOC101731574 LOC101731574 kat2a kat2a brca2 brca2 nup93 nup93 eomes eomes LOC100491917 LOC100491917 naa50 naa50 bag6 bag6 ING4 ING4 supt3h supt3h tex30 tex30 taf4 taf4 JADE2 JADE2 ruvbl1 ruvbl1 znf420-2 znf420-2 FOXP3 FOXP3 mcm8 mcm8 supt7l supt7l taf12 taf12 nat8.9 nat8.9 nat8.8 nat8.8 nat8.7 nat8.7 nat8.5 nat8.5 Crtc2 Crtc2 sowaha sowaha nat8.1 nat8.1 kat5 kat5 atxn7 atxn7 ovos2-3 ovos2-3 TAF2 TAF2 msl2 msl2 c6orf136 c6orf136 vps72 vps72 atat1 atat1 zmpste24 zmpste24 yeats2 yeats2 gtf3c4 gtf3c4 brd1 brd1 pbxip1 pbxip1 taf1 taf1 cuzd1.2 cuzd1.2 cspg4l cspg4l actl6a actl6a ogt ogt morf4l1 morf4l1 kansl3 kansl3 LOC100485335 LOC100485335 MAP3K7 MAP3K7 zzz3 zzz3 mllt1 mllt1 pole3 pole3 msl3 msl3 taf5l taf5l epc1 epc1 wdr5 wdr5 TRRAP TRRAP rab15-2 rab15-2 pus10 pus10 ENSXETP00000043168 ENSXETP00000043168 ing5 ing5 mcm3ap mcm3ap TAF6L TAF6L PHF20L1 PHF20L1 mcrs1 mcrs1 ATXN7L1 ATXN7L1 begain begain kat14 kat14 brd8 brd8 kat7 kat7 arhgap21 arhgap21 mbip mbip ing3 ing3 bmi1 bmi1 KAT2B KAT2B pcgf2 pcgf2 brpf3 brpf3 dr1 dr1 gtf2b gtf2b meaf6 meaf6 brpf1 brpf1 dmap1 dmap1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ep300Suv3 like RNA helicase. (2493 aa)
msl1PEHE domain-containing protein. (495 aa)
pax6Uncharacterized protein. (456 aa)
dhx58-2Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (292 aa)
taf5Myeloid-associated differentiation marker homolog. (777 aa)
PHF20PHD finger protein 20. (987 aa)
trim16Uncharacterized protein. (551 aa)
kat8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (506 aa)
kansl1Obg-like ATPase 1. (863 aa)
kansl2Cellular communication network factor 2. (530 aa)
naa60N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N- terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences. (242 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (470 aa)
hat1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (426 aa)
yeats4RecQ mediated genome instability 1. (227 aa)
sgf29Pseudouridine synthase like 1. (269 aa)
lef1HMG box domain-containing protein. (415 aa)
mllt3AHD domain-containing protein. (578 aa)
TAF6TATA-box binding protein associated factor 6. (395 aa)
naa40ATP binding cassette subfamily F member 2. (236 aa)
BEND3Uncharacterized protein. (838 aa)
jade1Complement factor properdin. (833 aa)
SMC5Structural maintenance of chromosomes 5. (1069 aa)
mecp2Kruppel-like factor 17. (466 aa)
LOC101731574Bromo domain-containing protein. (84 aa)
kat2aHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (779 aa)
brca2StAR related lipid transfer domain containing 9. (3138 aa)
nup93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (841 aa)
eomesAutophagy related 12. (674 aa)
LOC100491917Sphingosine kinase 2. (903 aa)
naa50N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. The relevance of N- epsilon-acetyltransferase activity is however unclear. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin [...] (169 aa)
bag6Large proline-rich protein bag6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1135 aa)
ING4Inhibitor of growth protein. (288 aa)
supt3hUncharacterized protein. (414 aa)
tex30DLH domain-containing protein. (225 aa)
taf4Centrin 4. (1045 aa)
JADE2Uncharacterized protein. (853 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
znf420-2Zinc finger protein 420. (128 aa)
FOXP3Forkhead box P3. (412 aa)
mcm8DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. In eggs, required for elongation during DNA replication by facilitating the recruitment of rpa2/rpa34 and stimulating the processivity of DNA polymerases at replication [...] (843 aa)
supt7lBTP domain-containing protein. (412 aa)
taf12Microtubule associated serine/threonine kinase 1. (218 aa)
nat8.9N-acetyltransferase domain-containing protein. (220 aa)
nat8.8Eukaryotic translation initiation factor 4E nuclear import factor 1. (220 aa)
nat8.7ISL LIM homeobox 1. (286 aa)
nat8.5Integrin subunit alpha 1. (219 aa)
Crtc2TORC_N domain-containing protein. (54 aa)
sowahaSosondowah ankyrin repeat domain family member A. (218 aa)
nat8.1LOC100124951 protein. (221 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (535 aa)
atxn7SCA7 domain-containing protein. (905 aa)
ovos2-3Alpha-2-macroglobulin like 1 pseudogene. (2368 aa)
TAF2TATA-box binding protein associated factor 2. (1191 aa)
msl2RING-type domain-containing protein. (580 aa)
c6orf136Granzyme H. (366 aa)
vps72Guanine nucleotide binding protein (G protein), alpha 15 (Gq class). (362 aa)
atat1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (419 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
yeats2Dynein axonemal assembly factor 4. (1245 aa)
gtf3c4Macrophage stimulating 1 receptor. (775 aa)
brd1Bromodomain-containing 1. (1185 aa)
pbxip1Protein interacting with PRKCA 1. (754 aa)
taf1Transcription initiation factor TFIID subunit. (1949 aa)
cuzd1.2Myogenic factor. (508 aa)
cspg4lChondroitin sulfate proteoglycan 4-like. (170 aa)
actl6aUncharacterized protein; Belongs to the actin family. (440 aa)
ogtEnolase 4. (1073 aa)
morf4l1Component of oligomeric golgi complex 3. (375 aa)
kansl3Uncharacterized protein. (1086 aa)
LOC100485335Poly(A) polymerase alpha. (281 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (594 aa)
zzz3Exostosin-like glycosyltransferase 2. (886 aa)
mllt1Pyruvate kinase L/R. (563 aa)
pole3Polymerase (DNA directed), epsilon 3 (P17 subunit). (147 aa)
msl3UTP23, small subunit processome component. (393 aa)
taf5lRelaxin family peptide receptor 3. (588 aa)
epc1Enhancer of polycomb homolog. (767 aa)
wdr5WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). (334 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3845 aa)
rab15-2RAB15, member RAS oncogene family. (609 aa)
pus10Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (240 aa)
ENSXETP00000043168H15 domain-containing protein. (199 aa)
ing5Inhibitor of growth protein. (236 aa)
mcm3apUbiquitin-protein ligase E3B. (2384 aa)
TAF6LTATA-box binding protein associated factor 6 like. (574 aa)
PHF20L1PHD finger protein 20 like 1. (889 aa)
mcrs1Microspherule protein 1. (453 aa)
ATXN7L1Ataxin 7 like 1. (902 aa)
begainUncharacterized protein. (643 aa)
kat14CSRP2 binding protein. (776 aa)
brd8Spastic paraplegia 7 (pure and complicated autosomal recessive). (882 aa)
kat7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (618 aa)
arhgap21Rho GTPase-activating protein 21; GTPase-activating protein (GAP) for rhoa and cdc42. (1933 aa)
mbipUncharacterized protein. (330 aa)
ing3Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity); Belongs to the ING family. (417 aa)
bmi1Quinolinate phosphoribosyltransferase. (325 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
pcgf2Vesicle (multivesicular body) trafficking 1. (317 aa)
brpf3LOC779492 protein. (983 aa)
dr1Down-regulator of transcription 1, TBP-binding (Negative cofactor 2). (175 aa)
gtf2bArginyl-tRNA synthetase 2, mitochondrial. (322 aa)
meaf6Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] (250 aa)
brpf1Uncharacterized protein. (1273 aa)
dmap1Uncharacterized protein. (476 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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