STRINGSTRING
csnk2b csnk2b irf5 irf5 RIPK2 RIPK2 ENSXETP00000001825 ENSXETP00000001825 RELT RELT EDA EDA mcm10 mcm10 LOC101733520 LOC101733520 il27ra il27ra ENSXETP00000003747 ENSXETP00000003747 irf1 irf1 csf1r csf1r ifnar2.1 ifnar2.1 ifngr2.2 ifngr2.2 ywhag-2 ywhag-2 traf5 traf5 usp7-2 usp7-2 nfkbia nfkbia stat4 stat4 TYK2 TYK2 il2rg il2rg ENSXETP00000009281 ENSXETP00000009281 LOC101732839 LOC101732839 sgcb-2 sgcb-2 ENSXETP00000010053 ENSXETP00000010053 LOC105945198 LOC105945198 ACKR4 ACKR4 ENSXETP00000011099 ENSXETP00000011099 bace2-2 bace2-2 dok1 dok1 ilk ilk sh2b3 sh2b3 il20rb il20rb ado-2 ado-2 gfra4 gfra4 GHR GHR irak1 irak1 st18 st18 nmi nmi irf7 irf7 zranb3-2 zranb3-2 TNFSF11 TNFSF11 tpm3 tpm3 tmc4 tmc4 il1r2 il1r2 appl2 appl2 stk39 stk39 appl1 appl1 chuk chuk LOC100491070 LOC100491070 cd74 cd74 tnfsf13b tnfsf13b stat5b stat5b ENSXETP00000018850 ENSXETP00000018850 stat3.2 stat3.2 mkks mkks pdgfb-2 pdgfb-2 stat3.1 stat3.1 il11ra il11ra traf3ip3 traf3ip3 krt8.1 krt8.1 CXCR5 CXCR5 LOC101733412 LOC101733412 ENSXETP00000020321 ENSXETP00000020321 ENSXETP00000020341 ENSXETP00000020341 LOC101734051 LOC101734051 ENSXETP00000020392 ENSXETP00000020392 il17d il17d edn2 edn2 FZD4 FZD4 irak4 irak4 ENSXETP00000022548 ENSXETP00000022548 CCR7 CCR7 ccr2 ccr2 CXCR6 CXCR6 adipor1 adipor1 kdm6a-2 kdm6a-2 pycard pycard wbp1l wbp1l Il6 Il6 TRAF2 TRAF2 il34 il34 tnfrsf19 tnfrsf19 Cntf Cntf eda2r eda2r CCR9 CCR9 CARD14 CARD14 ENSXETP00000026598 ENSXETP00000026598 ifngr2.1 ifngr2.1 ifnar1 ifnar1 Ccl20 Ccl20 stat1 stat1 GFRAL GFRAL csf3r csf3r rps6ka4 rps6ka4 plvap plvap irf6 irf6 irf6.2 irf6.2 epo epo kit kit crlf1 crlf1 nup153-2 nup153-2 LOC100498234 LOC100498234 eda2r-2 eda2r-2 cxcl8 cxcl8 csf2rb csf2rb ereg ereg TNFRSF11A TNFRSF11A ENSXETP00000032267 ENSXETP00000032267 smad4.1 smad4.1 lep lep foxc1 foxc1 PRLR PRLR cradd.2-2 cradd.2-2 hpx hpx ifnlr1 ifnlr1 tnfrsf1a tnfrsf1a cdip1 cdip1 ENSXETP00000034825 ENSXETP00000034825 LOC100498468 LOC100498468 ifngr1 ifngr1 csf1 csf1 ENSXETP00000035129 ENSXETP00000035129 mrps23-2 mrps23-2 LIFR LIFR irf3 irf3 CLDN18 CLDN18 GPR75 GPR75 CXCR3 CXCR3 cxcr3 cxcr3 LOC100496716 LOC100496716 cxcl12 cxcl12 IL16 IL16 bad bad traf6 traf6 stat6 stat6 Ccl5 Ccl5 rabgef1 rabgef1 syk syk IL6ST IL6ST ebi3 ebi3 traf1 traf1 jak3 jak3 cav3.2 cav3.2 CCR8 CCR8 lyn lyn prss23-2 prss23-2 duox1 duox1 il1rap il1rap tp53 tp53 socs5 socs5 epor epor cib1 cib1 ikbkb ikbkb il5ra il5ra cxcl11 cxcl11 cxcl9 cxcl9 nlgn3-2 nlgn3-2 il4r il4r JAK1 JAK1 il13ra2 il13ra2 cav3.1 cav3.1 irak2 irak2 cxcr4 cxcr4 lepr lepr ENSXETP00000047944 ENSXETP00000047944 notch4 notch4 oxsr1 oxsr1 gfra3 gfra3 traf3 traf3 cav1 cav1 CCR6 CCR6 il13ra1 il13ra1 sirt1 sirt1 bbs2 bbs2 ackr3 ackr3 il1b il1b jagn1 jagn1 IL17RE IL17RE il17rc il17rc ankhd1-2 ankhd1-2 notch1 notch1 socs1 socs1 jak2 jak2 rps6ka5 rps6ka5 LOC101730633 LOC101730633 tnf tnf IL17RD IL17RD gfra2 gfra2 Il1r1 Il1r1 ENSXETP00000000546 ENSXETP00000000546 IL18R1 IL18R1 ENSXETP00000000456 ENSXETP00000000456 stat2 stat2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
irf5IRF tryptophan pentad repeat domain-containing protein. (514 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (408 aa)
ENSXETP00000001825SCY domain-containing protein. (95 aa)
RELTUncharacterized protein. (396 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (361 aa)
mcm10Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). (845 aa)
LOC101733520C-C motif chemokine. (91 aa)
il27raUncharacterized protein. (473 aa)
ENSXETP00000003747G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
irf1Interferon regulatory factor. (302 aa)
csf1rUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (935 aa)
ifnar2.1Fibronectin type-III domain-containing protein. (498 aa)
ifngr2.2Lactamase beta. (337 aa)
ywhag-2Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma. (190 aa)
traf5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (539 aa)
usp7-2Ubiquitin specific peptidase 7 (herpes virus-associated). (316 aa)
nfkbiaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (315 aa)
stat4Signal transducer and activator of transcription. (689 aa)
TYK2Tyrosine-protein kinase. (1195 aa)
il2rgFibronectin type-III domain-containing protein. (329 aa)
ENSXETP00000009281Uncharacterized protein. (341 aa)
LOC101732839Protein kinase domain-containing protein. (580 aa)
sgcb-2Sarcoglycan beta. (185 aa)
ENSXETP00000010053Uncharacterized protein. (186 aa)
LOC105945198Type I interferon 4. (189 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
ENSXETP00000011099Uncharacterized protein. (197 aa)
bace2-2Purinergic receptor P2X, ligand gated ion channel, 2. (177 aa)
dok1BAH domain and coiled-coil containing 1. (566 aa)
ilkUncharacterized protein. (286 aa)
sh2b3Uncharacterized protein. (617 aa)
il20rbHost cell factor C1. (320 aa)
ado-22-aminoethanethiol (cysteamine) dioxygenase. (378 aa)
gfra4Calpastatin. (457 aa)
GHRGrowth hormone receptor. (621 aa)
irak1Peroxisomal membrane protein PEX16. (760 aa)
st18CECR2, histone acetyl-lysine reader. (1007 aa)
nmiUncharacterized protein. (466 aa)
irf7Dipeptidyl-peptidase 10 (inactive). (388 aa)
zranb3-2Zinc finger RAN-binding domain containing 3. (125 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (290 aa)
tpm3Tropomyosin 3. (197 aa)
tmc4Transmembrane channel like 4. (432 aa)
il1r2GATA binding protein 6. (349 aa)
appl2Alveolar soft part sarcoma chromosome region, candidate 1. (664 aa)
stk39Serine threonine kinase 39 (STE20/SPS1 homolog). (526 aa)
appl1K(lysine) acetyltransferase 8. (685 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (707 aa)
LOC100491070Uncharacterized protein. (469 aa)
cd74Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
tnfsf13bRegulatory factor X associated protein; Belongs to the tumor necrosis factor family. (266 aa)
stat5bSignal transducer and activator of transcription. (834 aa)
ENSXETP00000018850SH2 domain-containing protein. (475 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
mkksNeuronal calcium sensor 1. (611 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
il11raFibronectin type-III domain-containing protein. (249 aa)
traf3ip3TRAF3 interacting protein 2. (333 aa)
krt8.1Keratin 8; Belongs to the intermediate filament family. (508 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC101733412EPS8 like 1. (594 aa)
ENSXETP00000020321S-adenosylmethionine sensor upstream of mTORC1. (158 aa)
ENSXETP00000020341Uncharacterized protein. (159 aa)
LOC101734051Probable glutamate--tRNA ligase, mitochondrial. (152 aa)
ENSXETP00000020392Uncharacterized protein. (157 aa)
il17dUncharacterized protein. (217 aa)
edn2Mesoderm induction early response 1, family member 2. (168 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
irak4Irak4 protein. (457 aa)
ENSXETP00000022548IL12p40_C domain-containing protein. (249 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (358 aa)
ccr21-acylglycerol-3-phosphate O-acyltransferase 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CXCR6C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (327 aa)
adipor1Adiponectin receptor 1. (379 aa)
kdm6a-2Lysine demethylase 6A. (185 aa)
pycardFamily with sequence similarity 84 member B. (199 aa)
wbp1lUncharacterized protein. (415 aa)
Il6Uncharacterized protein. (150 aa)
TRAF2TNF receptor-associated factor. (481 aa)
il34Uncharacterized protein. (193 aa)
tnfrsf19POZ/BTB and AT hook containing zinc finger 1. (395 aa)
CntfUncharacterized protein. (171 aa)
eda2rCarbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7. (294 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CARD14Caspase recruitment domain family member 14. (994 aa)
ENSXETP00000026598G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (448 aa)
ifngr2.1Uncharacterized protein. (311 aa)
ifnar1Uncharacterized protein. (642 aa)
Ccl20C-C motif chemokine. (85 aa)
stat1Signal transducer and activator of transcription. (751 aa)
GFRALGDNF family receptor alpha like. (334 aa)
csf3rUncharacterized protein. (808 aa)
rps6ka4Non-specific serine/threonine protein kinase. (1260 aa)
plvapUncharacterized protein. (366 aa)
irf6Novel protein similar to interferon regulatory factor transcription factor. (460 aa)
irf6.2Novel protein similar to interferon regulatory factor transcription factor. (460 aa)
epoEstrogen related receptor alpha. (183 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
crlf1Mitochondrial E3 ubiquitin protein ligase 1. (387 aa)
nup153-2Amine oxidase, copper containing 1. (291 aa)
LOC100498234Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (112 aa)
eda2r-2Ectodysplasin A2 receptor. (329 aa)
cxcl8Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (130 aa)
csf2rbUncharacterized protein. (757 aa)
eregNIMA-related kinase 6. (156 aa)
TNFRSF11ATNF receptor superfamily member 11a. (579 aa)
ENSXETP00000032267Type I interferon 5. (189 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
foxc1Forkhead box protein C1; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epi [...] (495 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (607 aa)
cradd.2-2Phospholipase A2 group III. (137 aa)
hpxMORC family CW-type zinc finger 2. (320 aa)
ifnlr1Interferon lambda receptor transcript variant 3. (497 aa)
tnfrsf1aUncharacterized protein. (413 aa)
cdip1Cell death-inducing p53-target protein 1; May act as a p53/TP53-apoptotic effector. (207 aa)
ENSXETP00000034825Uncharacterized protein. (666 aa)
LOC100498468Uncharacterized protein. (471 aa)
ifngr1Uncharacterized protein. (433 aa)
csf1Nucleophosmin/nucleoplasmin 3. (384 aa)
ENSXETP00000035129Interleukin 20 receptor subunit alpha. (568 aa)
mrps23-2Sulfotransferase family 2B member 1. (218 aa)
LIFRLIF receptor subunit alpha. (1009 aa)
irf3Transmembrane 6 superfamily member 2. (470 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (260 aa)
GPR75G protein-coupled receptor 75. (525 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
cxcr3Chemokine (C-X-C motif) receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
LOC100496716Uncharacterized protein. (195 aa)
cxcl12Stromal cell-derived factor 1; Chemoattractant. Activates the C-X-C chemokine receptor cxcr4 to induce a rapid and transient rise in the level of intracellular calcium ions, and chemotaxis. Signaling with cxcr4 mediates the directional movement of mesodermal cells during gastrulation. Binds to the allosteric site (site 2) of integrins and activates them in a cxcr4-independent manner. (109 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1254 aa)
badSMC5-SMC6 complex localization factor 1. (151 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (558 aa)
stat6Signal transducer and activator of transcription. (787 aa)
Ccl5C-C motif chemokine. (99 aa)
rabgef1SET nuclear proto-oncogene. (538 aa)
sykTyrosine-protein kinase. (611 aa)
IL6STInterleukin 6 signal transducer. (948 aa)
ebi3Beta-1,4-glucuronyltransferase 1. (188 aa)
traf1TNF receptor-associated factor. (379 aa)
jak3Tyrosine-protein kinase. (1107 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
CCR8G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
lynTyrosine-protein kinase. (524 aa)
prss23-2Serine protease 23. (1449 aa)
duox1Synemin. (1460 aa)
il1rapUncharacterized protein. (690 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
socs5Suppressor of cytokine signaling 5. (535 aa)
eporBeta-galactoside alpha-2,6-sialyltransferase 2. (526 aa)
cib1Calcium and integrin binding 1 (Calmyrin). (190 aa)
ikbkbUncharacterized protein. (769 aa)
il5raMIS18 binding protein 1. (433 aa)
cxcl11Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
cxcl9Cyclin-dependent kinase 2 associated protein 2. (96 aa)
nlgn3-2Fibronectin type-III domain-containing protein. (460 aa)
il4rMesenteric estrogen-dependent adipogenesis. (934 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
il13ra2Tetratricopeptide repeat domain 16. (397 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
irak2NOP2/Sun RNA methyltransferase family member 7. (666 aa)
cxcr4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular calcium ion level. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation. May play a role in the migration of embryonic presumptive primordial germ cells (pPGCs). May also be involved in regulating migration of hematopoietic stem cells into the larval liver (By similarity). (358 aa)
leprLeucine-rich repeat-containing protein 42. (1138 aa)
ENSXETP00000047944Uncharacterized protein. (497 aa)
notch4Uncharacterized protein. (1581 aa)
oxsr1Homeodomain interacting protein kinase 3. (639 aa)
gfra3Uncharacterized protein. (416 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (354 aa)
il13ra1Cleavage stimulation factor, 3' pre-RNA, subunit 1. (357 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
bbs2Bardet-Biedl syndrome 2 protein homolog. (749 aa)
ackr3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (361 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
jagn1Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Belongs to the jagunal family. (183 aa)
IL17REInterleukin 17 receptor E. (696 aa)
il17rcSEFIR domain-containing protein. (762 aa)
ankhd1-2Ankyrin repeat and KH domain containing 1. (162 aa)
notch1Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2535 aa)
socs1Novel protein similar to suppressor of cytokine signaling 1. (211 aa)
jak2Tyrosine-protein kinase. (1129 aa)
rps6ka5Ribosomal protein S6 kinase. (835 aa)
LOC101730633SCY domain-containing protein. (94 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
IL17RDInterleukin 17 receptor D. (729 aa)
gfra2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (454 aa)
Il1r1TIR domain-containing protein. (293 aa)
ENSXETP00000000546Uncharacterized protein. (199 aa)
IL18R1Interleukin 18 receptor 1. (395 aa)
ENSXETP00000000456Uncharacterized protein. (198 aa)
stat2Signal transducer and activator of transcription. (765 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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