STRINGSTRING
sall4 sall4 RIF1 RIF1 lig4 lig4 HOOK3 HOOK3 mettl14 mettl14 wnt9b.2 wnt9b.2 SRRT SRRT cdx2 cdx2 med30 med30 pelo pelo NIPBL NIPBL SMC5 SMC5 gnl3 gnl3 tut4 tut4 eomes eomes piwil2 piwil2 KLF10 KLF10 jag1 jag1 stat3.2 stat3.2 lrp5 lrp5 PRDM14 PRDM14 stat3.1 stat3.1 BCL9L BCL9L zfp36l2 zfp36l2 mmp24 mmp24 PCM1 PCM1 smc3 smc3 dlc dlc trim8 trim8 ctr9 ctr9 vps72 vps72 abca4-3 abca4-3 dll1 dll1 MED15 MED15 BCL9 BCL9 BRAF BRAF faxc faxc mettl3 mettl3 tert-2 tert-2 fgf4 fgf4 med21 med21 NR2E1 NR2E1 cdc73 cdc73 lin28a lin28a eif4enif1 eif4enif1 fancd2 fancd2 med14 med14 mcph1 mcph1 dis3l2 dis3l2 wnt9b wnt9b REST REST FANCC FANCC ell-2 ell-2 lsm1 lsm1 LEO1 LEO1 rtf1 rtf1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sall4Sal-like 4. (1067 aa)
RIF1Replication timing regulatory factor 1. (2264 aa)
lig4DNA ligase. (911 aa)
HOOK3Hook microtubule tethering protein 3. (724 aa)
mettl14N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (457 aa)
wnt9b.2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
SRRTUncharacterized protein. (853 aa)
cdx2Caudal type homeo box transcription factor 2. (252 aa)
med30Uncharacterized protein. (184 aa)
peloUncharacterized protein. (290 aa)
NIPBLNipped-B protein. (2938 aa)
SMC5Structural maintenance of chromosomes 5. (1069 aa)
gnl3Receptor tyrosine kinase like orphan receptor 2. (472 aa)
tut4Thymidylate synthetase. (1562 aa)
eomesAutophagy related 12. (674 aa)
piwil2Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During [...] (949 aa)
KLF10Kruppel like factor 10. (465 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa)
PRDM14PR/SET domain 14. (531 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
BCL9LBCL9 like. (1282 aa)
zfp36l2mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-con [...] (362 aa)
mmp24Tripartite motif containing 14. (630 aa)
PCM1Pericentriolar material 1. (2051 aa)
smc3Structural maintenance of chromosomes protein. (1238 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
trim8Fin bud initiation factor homolog. (551 aa)
ctr9RNA polymerase-associated protein CTR9 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II (By similarity). PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (1149 aa)
vps72Guanine nucleotide binding protein (G protein), alpha 15 (Gq class). (362 aa)
abca4-3ATP binding cassette subfamily A member 4. (174 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (808 aa)
BCL9BCL9 transcription coactivator. (1475 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
faxcFailed axon connections homolog; May play a role in axonal development; Belongs to the FAX family. (406 aa)
mettl3Lysine (K)-specific demethylase 1B; Belongs to the MT-A70-like family. (573 aa)
tert-2Myotubularin related protein 12. (243 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
med21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (177 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (397 aa)
cdc73Hyperparathyroidism 2 (With jaw tumor). (531 aa)
lin28aProtein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (195 aa)
eif4enif1Uncharacterized protein. (957 aa)
fancd2Riboflavin kinase. (1432 aa)
med14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1460 aa)
mcph1Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa. (820 aa)
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (812 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
RESTRE1 silencing transcription factor. (1442 aa)
FANCCFA complementation group C. (544 aa)
ell-2Nanos-type domain-containing protein; Belongs to the nanos family. (290 aa)
lsm1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (240 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (718 aa)
rtf1Plus3 domain-containing protein. (675 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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