node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSXETP00000005412 | pcna | ENSXETP00000005412 | ENSXETP00000010344 | SprT-like domain-containing protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.577 |
ENSXETP00000005412 | vcp | ENSXETP00000005412 | ENSXETP00000015296 | SprT-like domain-containing protein. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive qua [...] | 0.421 |
LOC101732407.1 | pcna | ENSXETP00000035843 | ENSXETP00000010344 | SprT-like domain-containing protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.577 |
LOC101732407.1 | vcp | ENSXETP00000035843 | ENSXETP00000015296 | SprT-like domain-containing protein. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive qua [...] | 0.421 |
LOC105948375 | pcna | ENSXETP00000023244 | ENSXETP00000010344 | SprT-like domain-containing protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.577 |
LOC105948375 | vcp | ENSXETP00000023244 | ENSXETP00000015296 | SprT-like domain-containing protein. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive qua [...] | 0.421 |
LOC105948377 | pcna | ENSXETP00000027961 | ENSXETP00000010344 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.577 |
LOC105948377 | vcp | ENSXETP00000027961 | ENSXETP00000015296 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive qua [...] | 0.421 |
REV3L | pcna | ENSXETP00000001234 | ENSXETP00000010344 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.917 |
REV3L | pold1 | ENSXETP00000001234 | ENSXETP00000016473 | REV3 like, DNA directed polymerase zeta catalytic subunit. | DNA polymerase. | 0.802 |
REV3L | pold2 | ENSXETP00000001234 | ENSXETP00000050034 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Uncharacterized protein. | 0.970 |
REV3L | pole2 | ENSXETP00000001234 | ENSXETP00000022766 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Uncharacterized protein. | 0.849 |
REV3L | poli | ENSXETP00000001234 | ENSXETP00000035848 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Neuronal guanine nucleotide exchange factor. | 0.954 |
REV3L | polk | ENSXETP00000001234 | ENSXETP00000000059 | REV3 like, DNA directed polymerase zeta catalytic subunit. | SEC31 homolog A, COPII coat complex component. | 0.846 |
REV3L | primpol | ENSXETP00000001234 | ENSXETP00000015533 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Ubiquitin protein ligase E3 component n-recognin 2. | 0.543 |
REV3L | rev1 | ENSXETP00000001234 | ENSXETP00000044231 | REV3 like, DNA directed polymerase zeta catalytic subunit. | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. | 0.986 |
arl1-2 | pcna | ENSXETP00000005404 | ENSXETP00000010344 | SprT-like domain-containing protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.577 |
arl1-2 | vcp | ENSXETP00000005404 | ENSXETP00000015296 | SprT-like domain-containing protein. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive qua [...] | 0.421 |
dtl | pclaf | ENSXETP00000028254 | ENSXETP00000004759 | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | PCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number (By similarity). | 0.492 |
dtl | pcna | ENSXETP00000028254 | ENSXETP00000010344 | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.912 |