STRINGSTRING
riok2 riok2 anapc5 anapc5 KNTC1 KNTC1 dync1li1 dync1li1 mad2l1bp mad2l1bp cenpe cenpe ndc80 ndc80 ccdc88a ccdc88a znf207 znf207 tpr tpr mad2l1 mad2l1 mad1l1 mad1l1 zwilch zwilch klhl22 klhl22 anapc4 anapc4 spdl1 spdl1 zbed1 zbed1 anapc7 anapc7 cdc16 cdc16 bcl7c bcl7c bcl7a bcl7a ENSXETP00000019943 ENSXETP00000019943 cul3 cul3 anapc11 anapc11 pcid2 pcid2 cdc6 cdc6 MGC115642 MGC115642 zw10 zw10 galc galc rilpl1 rilpl1 anapc15 anapc15 cdc27 cdc27 xrcc3 xrcc3 bub1 bub1 GEN1 GEN1 ube2c ube2c CDT1 CDT1 ttk ttk lcmt1 lcmt1 ENSXETP00000033155 ENSXETP00000033155 rb1 rb1 bub3 bub3 ATM ATM fbxo5 fbxo5 aurkb aurkb cdc23 cdc23 bub1b bub1b nsmce2 nsmce2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
riok2RIO domain-containing protein. (555 aa)
anapc5ANAPC5 domain-containing protein. (743 aa)
KNTC1Kinetochore associated 1. (2236 aa)
dync1li1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (529 aa)
mad2l1bpPoly(ADP-ribose) polymerase family member 6. (247 aa)
cenpeKinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (3296 aa)
ndc80Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa)
ccdc88aCoiled-coil domain containing 88A. (58 aa)
znf207Monocyte to macrophage differentiation-associated. (491 aa)
tprSOS Ras/Rho guanine nucleotide exchange factor 2. (2324 aa)
mad2l1PIF1 5'-to-3' DNA helicase. (203 aa)
mad1l1Neutrophil cytosolic factor 4. (605 aa)
zwilchProtein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity). (597 aa)
klhl22Kelch-like protein 22; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL22) ubiquitin ligase complex could mediate the monoubiquitination of PLK1 and regulate its activity in spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex may also be responsible for the ubiquitin-dependent proteasomal degradation of DEPDC5 and the activation of the TORC1 pathway. (665 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (770 aa)
spdl1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity); Belongs to the Spindly family. (611 aa)
zbed1Ninein. (453 aa)
anapc7Cyclin E1. (590 aa)
cdc16TPR_REGION domain-containing protein. (612 aa)
bcl7cSerine/threonine-protein kinase greatwall. (206 aa)
bcl7aB-cell CLL/lymphoma 7 protein family member A; Belongs to the BCL7 family. (231 aa)
ENSXETP00000019943ANAPC4_WD40 domain-containing protein. (82 aa)
cul3Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Involved in ER- Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). May play a role in the regulation of mittotic entry via ubiquitinati [...] (770 aa)
anapc11Guanine nucleotide binding protein (G protein), beta polypeptide 1-like. (84 aa)
pcid2Novel protein, containing PCI domain. (399 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (595 aa)
MGC115642Hypothetical protein MGC115642. (1061 aa)
zw10Uncharacterized protein. (780 aa)
galcGalactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. (678 aa)
rilpl1RILP-like protein 1; Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein (By similarity). Belongs to the RILPL family. (404 aa)
anapc15Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC15 family. (141 aa)
cdc27Phosphodiesterase 11A. (845 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa)
bub1BUB1 budding uninhibited by benzimidazoles 1 homolog. (1122 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (927 aa)
ube2cMyotubularin related protein 2; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
CDT1Chromatin licensing and DNA replication factor 1. (617 aa)
ttkProtein kinase domain-containing protein. (879 aa)
lcmt1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (350 aa)
ENSXETP00000033155ANAPC4_WD40 domain-containing protein. (95 aa)
rb1Uncharacterized protein. (914 aa)
bub3Uncharacterized protein. (342 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
fbxo5F-box only protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity. (391 aa)
aurkbAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (375 aa)
cdc23Serine/threonine kinase 36. (604 aa)
bub1bUncharacterized protein. (1022 aa)
nsmce2Ring finger protein 34, E3 ubiquitin protein ligase. (203 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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