STRINGSTRING
rad1-2 rad1-2 sema4a sema4a IL18R1 IL18R1 ptpn2 ptpn2 lig4 lig4 clcf1 clcf1 stk11 stk11 WNT1 WNT1 cmtm7 cmtm7 itfg2 itfg2 MALT1 MALT1 ep300 ep300 irf1 irf1 LOC100490493 LOC100490493 F7CYZ3_XENTR F7CYZ3_XENTR NKX2-3 NKX2-3 usp7-2 usp7-2 gon4l gon4l tmub2-2 tmub2-2 ENSXETP00000008614 ENSXETP00000008614 armc5 armc5 bax bax cd79a cd79a gpr89b gpr89b anxa1.3 anxa1.3 lef1 lef1 znf180-2 znf180-2 dock10 dock10 tusc2 tusc2 ENSXETP00000011401 ENSXETP00000011401 gmpr2-2 gmpr2-2 lgals1.3 lgals1.3 lgals1.1 lgals1.1 rag2 rag2 PAX1 PAX1 lrrc8a lrrc8a zbtb1 zbtb1 JAG2 JAG2 eomes eomes ntrk1 ntrk1 batf batf ikzf1 ikzf1 LOC100491070 LOC100491070 cd74 cd74 rsad2 rsad2 srf srf tnfsf13b tnfsf13b stat5b stat5b LOC100487470 LOC100487470 stat3.2 stat3.2 stat3.1 stat3.1 traf3ip3 traf3ip3 rabl3 rabl3 tgfb1 tgfb1 rhoh rhoh FOXP3 FOXP3 rorc rorc axl axl ENSXETP00000022548 ENSXETP00000022548 jmjd6 jmjd6 CCR7 CCR7 dlc dlc Il6 Il6 CCR9 CCR9 gli3 gli3 fadd fadd lfng lfng LOC100490663 LOC100490663 ebna1bp2-4 ebna1bp2-4 cd3g cd3g ubn1-2 ubn1-2 fnip1 fnip1 PSMB11 PSMB11 pknox1 pknox1 rora rora tsc1 tsc1 fzd5 fzd5 cebpg cebpg dll1 dll1 fzd8 fzd8 kit kit cdh17 cdh17 dcaf1 dcaf1 ENSXETP00000031154 ENSXETP00000031154 ENSXETP00000031491 ENSXETP00000031491 BRAF BRAF BCL2 BCL2 mtor mtor Dock10 Dock10 anxa1.1 anxa1.1 lep lep ENSXETP00000033234 ENSXETP00000033234 ABL1 ABL1 sp3 sp3 PRR7 PRR7 atg5 atg5 tmem98 tmem98 ENSXETP00000034825 ENSXETP00000034825 lgals1.4 lgals1.4 abl2 abl2 lgals1.2 lgals1.2 mertk mertk zap70 zap70 ENSXETP00000036481 ENSXETP00000036481 rag1 rag1 foxn1 foxn1 ptger4 ptger4 stat6 stat6 syk syk tcf7 tcf7 IKZF3 IKZF3 hlx hlx ENSXETP00000039406 ENSXETP00000039406 ATM ATM dnajb9 dnajb9 GPR18 GPR18 lyl1 lyl1 itm2a itm2a TOX TOX tp53 tp53 ctnnb1 ctnnb1 MSH2 MSH2 fbxo7 fbxo7 gata3 gata3 il4r il4r sash3 sash3 ENSXETP00000046118 ENSXETP00000046118 pcasp3 pcasp3 RC3H1 RC3H1 lepr lepr bcl11b bcl11b CD40LG CD40LG tbx21 tbx21 cldn5-2 cldn5-2 ENSXETP00000051440 ENSXETP00000051440 cbfb cbfb adhfe1 adhfe1 hectd1 hectd1 gm2a-2 gm2a-2 DLL4 DLL4 tpd52 tpd52 RIPK2 RIPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad1-2RAD1 checkpoint DNA exonuclease. (162 aa)
sema4aSema domain-containing protein; Belongs to the semaphorin family. (681 aa)
IL18R1Interleukin 18 receptor 1. (395 aa)
ptpn2Proteasome 26S subunit, non-ATPase 8. (498 aa)
lig4DNA ligase. (911 aa)
clcf1Cardiotrophin-like cytokine factor 1. (223 aa)
stk11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
cmtm7MGC107754 protein. (165 aa)
itfg2Uncharacterized protein. (441 aa)
MALT1MALT1 paracaspase. (799 aa)
ep300Suv3 like RNA helicase. (2493 aa)
irf1Interferon regulatory factor. (302 aa)
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
F7CYZ3_XENTRUncharacterized protein. (224 aa)
NKX2-3Homeobox domain-containing protein. (328 aa)
usp7-2Ubiquitin specific peptidase 7 (herpes virus-associated). (316 aa)
gon4lUncharacterized protein. (1817 aa)
tmub2-2Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (661 aa)
ENSXETP00000008614Uncharacterized protein. (162 aa)
armc5BTB domain-containing protein. (934 aa)
baxBCL2-associated X protein. (221 aa)
cd79aUrocanate hydratase 1. (239 aa)
gpr89bUncharacterized protein. (462 aa)
anxa1.3Annexin. (350 aa)
lef1HMG box domain-containing protein. (415 aa)
znf180-2Zinc finger protein 180. (153 aa)
dock10DHR-2 domain-containing protein; Belongs to the DOCK family. (433 aa)
tusc2Zinc finger protein 280D. (106 aa)
ENSXETP00000011401DDE_Tnp_1_7 domain-containing protein. (460 aa)
gmpr2-2Guanosine monophosphate reductase 2. (190 aa)
lgals1.3Galectin. (135 aa)
lgals1.1Galectin. (134 aa)
rag2ABI family member 3 binding protein. (520 aa)
PAX1Paired box 1. (357 aa)
lrrc8aCWC27 spliceosome-associated protein. (809 aa)
zbtb1CCR4-NOT transcription complex subunit 6-like. (685 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1133 aa)
eomesAutophagy related 12. (674 aa)
ntrk1Tyrosine-protein kinase receptor. (808 aa)
batfBasic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells; Belongs to the bZIP family. (115 aa)
ikzf1SIX homeobox 3. (536 aa)
LOC100491070Uncharacterized protein. (469 aa)
cd74Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
rsad2Proteasome subunit alpha 2. (393 aa)
srfHydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (359 aa)
tnfsf13bRegulatory factor X associated protein; Belongs to the tumor necrosis factor family. (266 aa)
stat5bSignal transducer and activator of transcription. (834 aa)
LOC100487470DDE_Tnp_1_7 domain-containing protein. (610 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
traf3ip3TRAF3 interacting protein 2. (333 aa)
rabl3Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (149 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
rhohLOC100145522 protein. (190 aa)
FOXP3Forkhead box P3. (412 aa)
rorcNR LBD domain-containing protein. (397 aa)
axlUncharacterized protein. (914 aa)
ENSXETP00000022548IL12p40_C domain-containing protein. (249 aa)
jmjd6JmjC domain-containing protein. (403 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (358 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
Il6Uncharacterized protein. (150 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (368 aa)
gli3Centrosomal protein 164kDa. (1566 aa)
faddZinc finger, NFX1-type containing 1, gene 2. (188 aa)
lfngBeta-1,3-N-acetylglucosaminyltransferase. (372 aa)
LOC100490663Uncharacterized protein; Belongs to the protein kinase superfamily. (439 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
cd3gIg_4 domain-containing protein. (164 aa)
ubn1-2Ubinuclein 1. (172 aa)
fnip1cAMP-responsive element modulator. (1163 aa)
PSMB11Proteasome subunit beta. (288 aa)
pknox1Homeobox domain-containing protein. (348 aa)
roraPotassium channel, two pore domain subfamily K, member 4. (518 aa)
tsc1Distal-less homeobox 1. (1139 aa)
fzd5Zinc finger DHHC-type containing 9; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
cebpgCCAAT/enhancer binding protein (C/EBP), gamma. (137 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
fzd8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
cdh17Retinol binding protein 3. (830 aa)
dcaf1NADPH oxidase 4. (1503 aa)
ENSXETP00000031154B cell linker. (489 aa)
ENSXETP00000031491Enhancer of polycomb homolog 1. (455 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2534 aa)
Dock10PH domain-containing protein. (498 aa)
anxa1.1Annexin. (675 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
ENSXETP00000033234annotation not available (481 aa)
ABL1Tyrosine-protein kinase. (1128 aa)
sp3Zona pellucida glycoprotein 3 (sperm receptor), gene 2. (731 aa)
PRR7Proline rich 7, synaptic. (260 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
tmem98LOC100145240 protein. (226 aa)
ENSXETP00000034825Uncharacterized protein. (666 aa)
lgals1.4Galectin. (126 aa)
abl2Tyrosine-protein kinase. (1100 aa)
lgals1.2Galectin. (135 aa)
mertkZona pellucida protein D. (946 aa)
zap70Tyrosine-protein kinase. (609 aa)
ENSXETP00000036481annotation not available (401 aa)
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (584 aa)
foxn1Diphthamide biosynthesis 5. (583 aa)
ptger4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
stat6Signal transducer and activator of transcription. (787 aa)
sykTyrosine-protein kinase. (611 aa)
tcf7HMG box domain-containing protein. (488 aa)
IKZF3IKAROS family zinc finger 3. (504 aa)
hlxCytosol aminopeptidase. (328 aa)
ENSXETP00000039406annotation not available (454 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
dnajb9Dnajb9 protein. (221 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
lyl1Sosondowah ankyrin repeat domain family member C. (388 aa)
itm2aGlucose-6-phosphate isomerase. (247 aa)
TOXThymocyte selection associated high mobility group box. (537 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
ctnnb1Dynactin subunit 5. (788 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
fbxo7F-box domain-containing protein. (499 aa)
gata3Uncharacterized protein. (454 aa)
il4rMesenteric estrogen-dependent adipogenesis. (934 aa)
sash3Novel protein similar to sly (CXorf9). (389 aa)
ENSXETP00000046118DDE_Tnp_1_7 domain-containing protein. (597 aa)
pcasp3Uncharacterized protein. (632 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
leprLeucine-rich repeat-containing protein 42. (1138 aa)
bcl11bAquaporin 7. (829 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (269 aa)
tbx21Leucine rich repeat containing 3B. (561 aa)
cldn5-2Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome). (421 aa)
ENSXETP00000051440Uncharacterized protein. (168 aa)
cbfbOlfactory receptor family 1 subfamily S member 1 (gene/pseudogene). (174 aa)
adhfe1Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (544 aa)
hectd1Fibrillarin. (2580 aa)
gm2a-2GM2 ganglioside activator. (587 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
tpd52Uncharacterized protein. (219 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (408 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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