STRINGSTRING
hivep1 hivep1 bmp2 bmp2 smad9 smad9 bmp6 bmp6 msx1 msx1 GDF7 GDF7 gdf6 gdf6 smad2 smad2 SMAD6 SMAD6 smad3 smad3 SMAD7 SMAD7 usp15 usp15 fkbp8 fkbp8 ventx1.2 ventx1.2 BMP10 BMP10 csgalnact1-2 csgalnact1-2 bmp7.2 bmp7.2 gdf5 gdf5 slc33a1 slc33a1 ENSXETP00000010102 ENSXETP00000010102 gdf1 gdf1 lef1 lef1 TGFB2 TGFB2 acvr1 acvr1 chrd.1 chrd.1 bmper bmper HJV HJV acvr2b acvr2b fam83g fam83g nodal nodal bmp4 bmp4 smurf1 smurf1 LOC100492768 LOC100492768 BMPR1A BMPR1A sfrp2 sfrp2 pdcd4 pdcd4 rgmb rgmb lefty lefty bmp7.1 bmp7.1 spart spart dlx5 dlx5 LOC448531 LOC448531 Smad6.2 Smad6.2 bmp15 bmp15 bmp5 bmp5 tmem100 tmem100 ventx1.1 ventx1.1 ventx3.1 ventx3.1 ventx3.2 ventx3.2 mms19 mms19 gdf3 gdf3 smad4.1 smad4.1 twsg1 twsg1 ddx5 ddx5 acvrl1 acvrl1 fst fst Znf831 Znf831 bmpr1b bmpr1b GDF2 GDF2 ncoa6-2 ncoa6-2 foxf1 foxf1 smad1 smad1 acvr2a acvr2a nodal5 nodal5 nvl-2 nvl-2 LOC101734231 LOC101734231 LOC101734157 LOC101734157 nodal6 nodal6 bmp8 bmp8 sostdc1 sostdc1 mettl23 mettl23 mreg mreg BMPR2 BMPR2 nodal-2 nodal-2 nodal2 nodal2 nodal1 nodal1 rgma rgma
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hivep1Cytoplasmic polyadenylation element-binding protein 3. (2591 aa)
bmp2Armadillo like helical domain containing 3. (398 aa)
smad9Mothers against decapentaplegic homolog. (466 aa)
bmp6Enhancer of mRNA decapping 4. (441 aa)
msx1Potassium channel, two pore domain subfamily K, member 18. (275 aa)
GDF7Growth differentiation factor 7. (414 aa)
gdf6Erb-b2 receptor tyrosine kinase 3. (396 aa)
smad2Mothers against decapentaplegic homolog. (467 aa)
SMAD6Mothers against decapentaplegic homolog. (352 aa)
smad3Mothers against decapentaplegic homolog. (461 aa)
SMAD7Mothers against decapentaplegic homolog. (382 aa)
usp15Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiqu [...] (982 aa)
fkbp8Peptidylprolyl isomerase. (408 aa)
ventx1.2Homeobox protein vent1; Transcriptional repressor. Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation. Acts downstream of bmp4 to repress transcription of foxa4- B/XFD-1'. Binds to DNA with preference for the target sequence 5'- CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene (By similarity). Cooperates with vent2 to repress my [...] (262 aa)
BMP10Bone morphogenetic protein 10. (421 aa)
csgalnact1-2Chemerin chemokine-like receptor 1. (132 aa)
bmp7.2Nuclear receptor subfamily 5 group A member 1. (436 aa)
gdf5Growth differentiation factor 5. (496 aa)
slc33a1Phospholipid phosphatase 3. (538 aa)
ENSXETP00000010102TGF_BETA_2 domain-containing protein. (294 aa)
gdf1Vg1. (361 aa)
lef1HMG box domain-containing protein. (415 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (568 aa)
chrd.1Chordin; Belongs to the chordin family. (942 aa)
bmperUncharacterized protein. (741 aa)
HJVHemojuvelin BMP co-receptor. (402 aa)
acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
fam83gGlucosidase, alpha; neutral C. (949 aa)
nodalRibosomal protein S12. (418 aa)
bmp4Zinc finger, HIT-type-containing 6. (469 aa)
smurf1E3 ubiquitin-protein ligase. (748 aa)
LOC100492768Peptidylprolyl isomerase. (424 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
pdcd4Uncharacterized protein. (486 aa)
rgmbAcetoacetyl-CoA synthetase. (459 aa)
leftyLeft-right determination factor. (365 aa)
bmp7.1TGF_BETA_2 domain-containing protein. (425 aa)
spartMIT domain-containing protein. (592 aa)
dlx5Nuclear factor of activated T cells 3. (298 aa)
LOC448531HGF activator. (260 aa)
Smad6.2MH2 domain-containing protein. (206 aa)
bmp15Intraflagellar transport 74. (379 aa)
bmp5Apoptosis antagonizing transcription factor. (449 aa)
tmem100Serine protease 1. (132 aa)
ventx1.1Homeobox domain-containing protein. (278 aa)
ventx3.1Ventx3.1 protein. (273 aa)
ventx3.2Homeobox protein vex1; Transcriptional repressor. Acts in a ventral signaling pathway downstream of bmp4 to antagonize the Spemann organizer and ventrally pattern the embryonic mesoderm. Represses transcription of the dorsal genes gsc and otx2 (By similarity). (282 aa)
mms19MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). (1048 aa)
gdf3Derriere protein; Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1. Can exert long-range effects in the embryo (By similarity). (354 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
twsg1Uncharacterized protein. (339 aa)
ddx5Uncharacterized protein; Belongs to the DEAD box helicase family. (618 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (490 aa)
fstChloride channel, voltage-sensitive 6. (343 aa)
Znf831Uncharacterized protein. (1264 aa)
bmpr1bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF2Growth differentiation factor 2. (410 aa)
ncoa6-2USP domain-containing protein; Belongs to the peptidase C19 family. (2558 aa)
foxf1Forkhead box protein F1; Probable transcription factor. Required for smooth muscle (visceral mesoderm) differentiation during gut development. Also required for normal proliferation of the lateral plate mesoderm. Acts as a downstream mediator of bmp4-signaling (By similarity). (373 aa)
smad1Mothers against decapentaplegic homolog. (464 aa)
acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (522 aa)
nodal5Polypeptide N-acetylgalactosaminyltransferase 7. (386 aa)
nvl-2Nuclear VCP like. (393 aa)
LOC101734231Protein phosphatase, Mg2+/Mn2+ dependent 1F. (386 aa)
LOC101734157TGF_BETA_2 domain-containing protein. (386 aa)
nodal6TGF_BETA_2 domain-containing protein. (382 aa)
bmp8TGF_BETA_2 domain-containing protein. (419 aa)
sostdc1Transmembrane protein 52. (213 aa)
mettl23Methyltransferase like 23. (175 aa)
mregMelanoregulin; Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinosi [...] (270 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa)
nodal-2Nodal homolog 3-C; Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp- signaling; Belongs to the TGF-beta family. (403 aa)
nodal2Neurotrophic receptor tyrosine kinase 3. (405 aa)
nodal1Nodal homolog; Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene c [...] (403 aa)
rgmaPre-mRNA-splicing factor SPF27. (459 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.