(44 nodes) Leukocyte chemotaxis network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANO6	Anoctamin. (909 aa)
	ppib	Antizyme inhibitor 1. (301 aa)
	ptpro	ORMDL sphingolipid biosynthesis regulator 1. (1018 aa)
	lgals3	Galectin. (256 aa)
	TAFA4	TAFA chemokine like family member 4. (221 aa)
	ednrb	Aconitase 2; Belongs to the G-protein coupled receptor 1 family. (433 aa)
	ffar3	Amylase, alpha 2B (pancreatic); Belongs to the G-protein coupled receptor 1 family. (322 aa)
	FFAR2	Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	anxa1.3	Annexin. (350 aa)
	itga1	Tetratricopeptide repeat domain 37; Belongs to the integrin alpha chain family. (1132 aa)
	scg2	BRX1, biogenesis of ribosomes. (624 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (290 aa)
	pdgfb-2	Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
	dtnb-2	Dystrobrevin beta. (329 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	LOC101733412	EPS8 like 1. (594 aa)
	edn2	Mesoderm induction early response 1, family member 2. (168 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	slc37a4	MFS domain-containing protein. (505 aa)
	ENSXETP00000026598	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	Ccl20	C-C motif chemokine. (85 aa)
	csf3r	Uncharacterized protein. (808 aa)
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
	pikfyve	Uncharacterized protein. (2104 aa)
	ENSXETP00000032157	Ion_trans domain-containing protein. (263 aa)
	anxa1.1	Annexin. (675 aa)
	bsg	Solute carrier family 25 member 13. (410 aa)
	slc7a2.2-2	Uncoupling protein 1. (1393 aa)
	cxcr3	Chemokine (C-X-C motif) receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1254 aa)
	syk	Tyrosine-protein kinase. (611 aa)
	gbf1	Olfactory receptor class II (xb178 gene). (1854 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (171 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1045 aa)
	ptn	Glycine receptor alpha 3. (190 aa)
	ednrb2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	gas6	Homeobox protein CDX-1. (672 aa)
	kdrl	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1015 aa)
	flt1	Keratin 18, gene 2. (970 aa)
	cxcl9	Cyclin-dependent kinase 2 associated protein 2. (96 aa)
	cxadr	Uncharacterized protein. (362 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (538 aa)
	cyp7b1	V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K; Belongs to the cytochrome P450 family. (491 aa)
	il17rc	SEFIR domain-containing protein. (762 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	CXCR5	ENSXETP00000023102	ENSXETP00000019894	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.626
CCR7	Ccl20	ENSXETP00000023102	ENSXETP00000027790	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.583
CCR7	cxcl9	ENSXETP00000023102	ENSXETP00000044932	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.726
CXCR5	CCR7	ENSXETP00000019894	ENSXETP00000023102	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.626
CXCR5	cxcl9	ENSXETP00000019894	ENSXETP00000044932	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.597
Ccl20	CCR7	ENSXETP00000027790	ENSXETP00000023102	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.583
Ccl20	TNFSF11	ENSXETP00000027790	ENSXETP00000015617	C-C motif chemokine.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.447
Ccl20	cxcl9	ENSXETP00000027790	ENSXETP00000044932	C-C motif chemokine.	Cyclin-dependent kinase 2 associated protein 2.	0.566
ENSXETP00000026598	cxcl9	ENSXETP00000026598	ENSXETP00000044932	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.527
IL16	LOC101733412	ENSXETP00000036489	ENSXETP00000020264	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.	EPS8 like 1.	0.526
LOC101733412	IL16	ENSXETP00000020264	ENSXETP00000036489	EPS8 like 1.	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.	0.526
LOC101733412	il17rc	ENSXETP00000020264	ENSXETP00000052429	EPS8 like 1.	SEFIR domain-containing protein.	0.970
TNFSF11	Ccl20	ENSXETP00000015617	ENSXETP00000027790	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	C-C motif chemokine.	0.447
cxcl9	CCR7	ENSXETP00000044932	ENSXETP00000023102	Cyclin-dependent kinase 2 associated protein 2.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.726
cxcl9	CXCR5	ENSXETP00000044932	ENSXETP00000019894	Cyclin-dependent kinase 2 associated protein 2.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.597
cxcl9	Ccl20	ENSXETP00000044932	ENSXETP00000027790	Cyclin-dependent kinase 2 associated protein 2.	C-C motif chemokine.	0.566
cxcl9	ENSXETP00000026598	ENSXETP00000044932	ENSXETP00000026598	Cyclin-dependent kinase 2 associated protein 2.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.527
cxcl9	cxcr3	ENSXETP00000044932	ENSXETP00000035945	Cyclin-dependent kinase 2 associated protein 2.	Chemokine (C-X-C motif) receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.965
cxcr3	cxcl9	ENSXETP00000035945	ENSXETP00000044932	Chemokine (C-X-C motif) receptor 3; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.965
edn2	ednrb	ENSXETP00000021329	ENSXETP00000008558	Mesoderm induction early response 1, family member 2.	Aconitase 2; Belongs to the G-protein coupled receptor 1 family.	0.962

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