(77 nodes) Synaptic vesicle membrane network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	slc18a1	DEAD-box helicase 42. (517 aa)
	tmem163	B-TFIID TATA-box binding protein associated factor 1. (281 aa)
	scamp5.1	Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines. Probably acts in cooperation with the SNARE machinery (By similarity); Belongs to the SCAMP family. SCAMP5 subfamily. (235 aa)
	LOC101730668	ABC transporter domain-containing protein. (310 aa)
	tra2b-2	Transformer 2 beta homolog. (207 aa)
	sytl4	Synaptotagmin like 4. (246 aa)
	SYT9	Synaptotagmin 9. (509 aa)
	mctp2	Tissue specific transplantation antigen P35B. (876 aa)
	stx10	t-SNARE coiled-coil homology domain-containing protein. (252 aa)
	SYT5	Synaptotagmin 5. (421 aa)
	syn2	Oxysterol binding protein like 1A. (877 aa)
	atp6v1b1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (492 aa)
	rab26	Uncharacterized protein. (249 aa)
	sv2a	Plastin 1. (729 aa)
	Prrt2	Membrane associated ring-CH-type finger 4. (74 aa)
	SYNGR3	Synaptogyrin. (227 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (499 aa)
	sv2c	Trace amine-associated receptor 1. (725 aa)
	rab35	RAB35, member RAS oncogene family. (201 aa)
	atp6v1g2	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (233 aa)
	pdhx-2	Oxysterol binding protein like 10. (49 aa)
	syt1	E2F transcription factor 4. (425 aa)
	atp6v1b2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (505 aa)
	bcl7b-2	BCL7B, BAF complex component. (4211 aa)
	lrrk2	Hes family bHLH transcription factor 2. (2514 aa)
	hormad1-2	KAT8 regulatory NSL complex subunit 3. (411 aa)
	LOC100495571	Allantoicase. (468 aa)
	lamp5	Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. (276 aa)
	LOC100487393	General transcription factor IIE, polypeptide 1, alpha 56kDa, gene 2. (500 aa)
	septin8	Septin-8. (462 aa)
	wfs1	LOC100127642 protein. (863 aa)
	slc17a6	LDL receptor related protein associated protein 1. (583 aa)
	borcs5	BLOC-1-related complex subunit 5; As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS5 family. (196 aa)
	slc9b2	Sodium/hydrogen exchanger 9B2; Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume (By similarity). (543 aa)
	dnm1l	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
	atp6v0a1	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity); Belongs to the V-ATPase 116 kDa subunit family. (863 aa)
	SYNPR	Synaptoporin. (283 aa)
	atp6ap1.2	Uncharacterized protein. (462 aa)
	mctp1	Adrenomedullin. (842 aa)
	unc13a	CCCTC-binding factor. (1677 aa)
	syp	LOC100144928 protein. (300 aa)
	LOC100496053	MFS domain-containing protein. (494 aa)
	slc17a7	Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. (594 aa)
	lman1l	Lectin, mannose-binding, 1 like. (158 aa)
	vamp1	Isocitrate dehydrogenase 1 (NADP+). (110 aa)
	syngr2	Synaptogyrin. (219 aa)
	slc30a3	Uncharacterized protein. (395 aa)
	syt12	Cilia and flagella associated protein 100. (414 aa)
	stx16	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (279 aa)
	rab35l	Uncharacterized protein. (201 aa)
	scamp1	Secretory carrier-associated membrane protein. (355 aa)
	en1	Engrailed homeobox 1. (436 aa)
	LOC100493529	Leucine zipper protein 2. (425 aa)
	syt7	C2 domain-containing protein. (777 aa)
	sypl2	Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (263 aa)
	gria1	TRAF3 interacting protein 2. (903 aa)
	SVOP	SV2 related protein. (585 aa)
	atp6v0c	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (156 aa)
	tprg1l	Hypothetical LOC496974. (268 aa)
	slc32a1	Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Belongs to the amino acid/polyamine transporter 2 family. (518 aa)
	renbp	Coenzyme Q8B. (414 aa)
	stx6	Regulator of G-protein signaling 10; Belongs to the syntaxin family. (264 aa)
	atp6ap2	Coiled-coil domain containing 148. (351 aa)
	unc13c	Acetyl-CoA acyltransferase 1. (2189 aa)
	syn3	Uncharacterized protein. (570 aa)
	sypl1	Synaptophysin-like 1. (234 aa)
	prrt1	Sushi domain containing 2. (240 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (223 aa)
	gad2	Peptidoglycan recognition protein 1. (588 aa)
	SLC17A8	Solute carrier family 17 member 8. (588 aa)
	bin1	Glutamate decarboxylase 1. (573 aa)
	sv2b	Desmoplakin. (711 aa)
	c16orf70	Uncharacterized protein. (423 aa)
	dtnbp1	Nuclear receptor coactivator 1. (355 aa)
	LOC100487454	Uncharacterized protein. (454 aa)
	amph	Uncharacterized protein. (671 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100487454	atp6ap1.2	ENSXETP00000052199	ENSXETP00000027044	Uncharacterized protein.	Uncharacterized protein.	0.904
LOC100487454	atp6ap2	ENSXETP00000052199	ENSXETP00000042903	Uncharacterized protein.	Coiled-coil domain containing 148.	0.951
LOC100487454	atp6v0a1	ENSXETP00000052199	ENSXETP00000023857	Uncharacterized protein.	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity); Belongs to the V-ATPase 116 kDa subunit family.	0.968
LOC100487454	atp6v0c	ENSXETP00000052199	ENSXETP00000038876	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.990
LOC100487454	atp6v1b1	ENSXETP00000052199	ENSXETP00000012004	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.835
LOC100487454	atp6v1b2	ENSXETP00000052199	ENSXETP00000017567	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.835
LOC100487454	atp6v1g2	ENSXETP00000052199	ENSXETP00000015910	Uncharacterized protein.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.820
LOC100493529	vamp1	ENSXETP00000035214	ENSXETP00000028943	Leucine zipper protein 2.	Isocitrate dehydrogenase 1 (NADP+).	0.679
SLC17A8	slc32a1	ENSXETP00000049877	ENSXETP00000039619	Solute carrier family 17 member 8.	Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Belongs to the amino acid/polyamine transporter 2 family.	0.484
SLC17A8	wfs1	ENSXETP00000049877	ENSXETP00000021838	Solute carrier family 17 member 8.	LOC100127642 protein.	0.404
SYNGR3	SYNPR	ENSXETP00000015281	ENSXETP00000025168	Synaptogyrin.	Synaptoporin.	0.499
SYNGR3	SYT5	ENSXETP00000015281	ENSXETP00000011717	Synaptogyrin.	Synaptotagmin 5.	0.479
SYNGR3	scamp1	ENSXETP00000015281	ENSXETP00000033017	Synaptogyrin.	Secretory carrier-associated membrane protein.	0.488
SYNPR	SYNGR3	ENSXETP00000025168	ENSXETP00000015281	Synaptoporin.	Synaptogyrin.	0.499
SYNPR	SYT5	ENSXETP00000025168	ENSXETP00000011717	Synaptoporin.	Synaptotagmin 5.	0.496
SYNPR	syngr2	ENSXETP00000025168	ENSXETP00000029063	Synaptoporin.	Synaptogyrin.	0.489
SYNPR	syt12	ENSXETP00000025168	ENSXETP00000031661	Synaptoporin.	Cilia and flagella associated protein 100.	0.560
SYNPR	vamp1	ENSXETP00000025168	ENSXETP00000028943	Synaptoporin.	Isocitrate dehydrogenase 1 (NADP+).	0.483
SYT5	SYNGR3	ENSXETP00000011717	ENSXETP00000015281	Synaptotagmin 5.	Synaptogyrin.	0.479
SYT5	SYNPR	ENSXETP00000011717	ENSXETP00000025168	Synaptotagmin 5.	Synaptoporin.	0.496

page 1 of 8

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About