(45 nodes) Regulation of actin filament depolymerization network (Xenopus tropicalis)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	RDX	Radixin. (602 aa)
	LOC101730842	PH domain-containing protein. (87 aa)
	svil	Coiled-coil domain containing 181. (2279 aa)
	mtpn	Myotrophin; Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity); Belongs to the myotrophin family. (118 aa)
	avil	1-acylglycerol-3-phosphate O-acyltransferase 2. (807 aa)
	lima1	LIM zinc-binding domain-containing protein. (717 aa)
	sh3bp1	Uncharacterized protein. (636 aa)
	plek	Pleckstrin. (350 aa)
	dmtn	HP domain-containing protein. (416 aa)
	SPTBN5	Spectrin beta, non-erythrocytic 5. (3355 aa)
	flii	Ras and Rab interactor 2. (1274 aa)
	add2	Aldolase_II domain-containing protein. (725 aa)
	sptbn4	Spectrin beta chain; Belongs to the spectrin family. (2535 aa)
	CRACD	KIAA1211. (1190 aa)
	tmod4	Uncharacterized protein. (381 aa)
	LOC108644441	Gelsolin-like domain-containing protein. (124 aa)
	sptbn2	Spectrin beta chain; Belongs to the spectrin family. (2406 aa)
	gsn	Uncharacterized protein. (744 aa)
	add3	ATR serine/threonine kinase. (565 aa)
	add1	Aldolase_II domain-containing protein. (823 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1466 aa)
	capg	Protein kinase C and casein kinase substrate in neurons 2. (347 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2358 aa)
	LMOD1	Leiomodin 1. (550 aa)
	wdr1	WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity); Belongs to the WD repeat AIP1 family. (609 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	tmod2	LOC100127704 protein. (352 aa)
	tmod3	Tropomodulin 3 (Ubiquitous). (344 aa)
	lmod2	LOC100145340 protein. (549 aa)
	dnajc2	DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription ac [...] (620 aa)
	vil1	HP domain-containing protein. (713 aa)
	capza2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (295 aa)
	LOC108644475	SH3 and PX domains 2B. (715 aa)
	scin	Kinetochore protein NDC80 homolog. (761 aa)
	ENSXETP00000048533	LIM zinc-binding domain-containing protein. (146 aa)
	sptb	Spectrin beta chain; Belongs to the spectrin family. (2342 aa)
	capza1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	def6	DEF6 guanine nucleotide exchange factor. (596 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
	glrx3	Glutaredoxin-3; Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. (329 aa)
	sptan1	Uncharacterized protein. (2491 aa)
	vill	JAZF zinc finger 1. (876 aa)
	rab3gap2-2	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (219 aa)
	twf1	Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (353 aa)
	CARMIL1	Capping protein regulator and myosin 1 linker 1. (1392 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARMIL1	capza1	ENSXETP00000026503	ENSXETP00000047849	Capping protein regulator and myosin 1 linker 1.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.853
CARMIL1	capza2	ENSXETP00000026503	ENSXETP00000049130	Capping protein regulator and myosin 1 linker 1.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.734
CARMIL1	rab3gap2-2	ENSXETP00000026503	ENSXETP00000000781	Capping protein regulator and myosin 1 linker 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.855
LOC101730842	sptan1	ENSXETP00000004274	ENSXETP00000044121	PH domain-containing protein.	Uncharacterized protein.	0.734
LOC108644441	LOC108644475	ENSXETP00000008347	ENSXETP00000048603	Gelsolin-like domain-containing protein.	SH3 and PX domains 2B.	0.901
LOC108644441	gsn	ENSXETP00000008347	ENSXETP00000009040	Gelsolin-like domain-containing protein.	Uncharacterized protein.	0.633
LOC108644441	scin	ENSXETP00000008347	ENSXETP00000048561	Gelsolin-like domain-containing protein.	Kinetochore protein NDC80 homolog.	0.901
LOC108644475	LOC108644441	ENSXETP00000048603	ENSXETP00000008347	SH3 and PX domains 2B.	Gelsolin-like domain-containing protein.	0.901
LOC108644475	scin	ENSXETP00000048603	ENSXETP00000048561	SH3 and PX domains 2B.	Kinetochore protein NDC80 homolog.	0.901
SPTBN1	sptan1	ENSXETP00000025470	ENSXETP00000044121	Spectrin beta chain; Belongs to the spectrin family.	Uncharacterized protein.	0.788
SPTBN5	sptan1	ENSXETP00000026566	ENSXETP00000044121	Spectrin beta, non-erythrocytic 5.	Uncharacterized protein.	0.734
TMOD1	add1	ENSXETP00000026454	ENSXETP00000016180	Tropomodulin 1.	Aldolase_II domain-containing protein.	0.431
TMOD1	add2	ENSXETP00000026454	ENSXETP00000005352	Tropomodulin 1.	Aldolase_II domain-containing protein.	0.418
TMOD1	add3	ENSXETP00000026454	ENSXETP00000014363	Tropomodulin 1.	ATR serine/threonine kinase.	0.419
add1	TMOD1	ENSXETP00000016180	ENSXETP00000026454	Aldolase_II domain-containing protein.	Tropomodulin 1.	0.431
add1	add2	ENSXETP00000016180	ENSXETP00000005352	Aldolase_II domain-containing protein.	Aldolase_II domain-containing protein.	0.692
add1	add3	ENSXETP00000016180	ENSXETP00000014363	Aldolase_II domain-containing protein.	ATR serine/threonine kinase.	0.494
add1	dmtn	ENSXETP00000016180	ENSXETP00000028948	Aldolase_II domain-containing protein.	HP domain-containing protein.	0.700
add1	tmod4	ENSXETP00000016180	ENSXETP00000006640	Aldolase_II domain-containing protein.	Uncharacterized protein.	0.431
add2	TMOD1	ENSXETP00000005352	ENSXETP00000026454	Aldolase_II domain-containing protein.	Tropomodulin 1.	0.418

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