STRINGSTRING
WNT1 WNT1 UCHL5 UCHL5 fzd3 fzd3 msx1 msx1 GDF7 GDF7 otx2 otx2 otx1 otx1 wnt9b.2 wnt9b.2 wnt3a wnt3a LOC101731015 LOC101731015 ryk ryk sos1 sos1 TAL2 TAL2 kdm7a kdm7a tfap2d tfap2d uqcrq uqcrq LRP6 LRP6 phox2a phox2a LOC100487954 LOC100487954 en2 en2 ctnnb1 ctnnb1 smad1 smad1 wnt3 wnt3 wnt9b wnt9b WNT2B WNT2B WNT2 WNT2 DLG5 DLG5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
fzd3Developmentally regulated GTP binding protein 1; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
msx1Potassium channel, two pore domain subfamily K, member 18. (275 aa)
GDF7Growth differentiation factor 7. (414 aa)
otx2Homeobox protein OTX2; May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix- A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (289 aa)
otx1Homeobox domain-containing protein. (338 aa)
wnt9b.2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LOC101731015Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
rykUncharacterized protein. (601 aa)
sos1Organic solute transporter subunit alpha. (1329 aa)
TAL2TAL bHLH transcription factor 2. (102 aa)
kdm7aLysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity); Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (912 aa)
tfap2dTF_AP-2 domain-containing protein. (452 aa)
uqcrqUncharacterized protein. (82 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
phox2aHomeobox domain-containing protein. (281 aa)
LOC100487954Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
en2Homeobox protein engrailed-like. (266 aa)
ctnnb1Dynactin subunit 5. (788 aa)
smad1Mothers against decapentaplegic homolog. (464 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1971 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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