(35 nodes) Pancreas development network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	bmp6	Enhancer of mRNA decapping 4. (441 aa)
	LOC101731483	Glutamate-rich WD repeat containing 1. (783 aa)
	pax6	Uncharacterized protein. (456 aa)
	nkx3-2	Homeobox domain-containing protein. (329 aa)
	nkx6-1	Meis homeobox 1. (348 aa)
	anxa1.3	Annexin. (350 aa)
	ccdc40	Uncharacterized protein. (607 aa)
	pdx1	Hepatocyte nuclear factor 4, beta. (271 aa)
	insm1	Insulinoma-associated protein 1; May act as a transcriptional regulator. Plays a role in noradrenergic neuron, pancreatic and gastrointestinal endocrine cells differentiation during embryonic development (By similarity). Belongs to the INSM1 family. (441 aa)
	fastkd1	FAST kinase domain-containing protein 1, mitochondrial; May regulate the stability of some mitochondrial mRNA species. (839 aa)
	wfs1	LOC100127642 protein. (863 aa)
	utp25	Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs; Belongs to the def family. (765 aa)
	igf2	IlGF domain-containing protein. (217 aa)
	dlc	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
	LOC108648942	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4. (191 aa)
	pcsk1	Zygote arrest 1; Belongs to the peptidase S8 family. (749 aa)
	HNF1B	HNF1 homeobox B. (566 aa)
	RFX6	Regulatory factor X6. (931 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
	anxa1.1	Annexin. (675 aa)
	LOC100485335	Poly(A) polymerase alpha. (281 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (339 aa)
	dnaaf1	Dynein assembly factor 1, axonemal. (612 aa)
	eif2ak3	Carnitine palmitoyltransferase 1A (liver) like. (929 aa)
	hnf1a	Heterogeneous nuclear ribonucleoprotein U-like 1. (622 aa)
	sox17a	Transcription factor Sox-17-alpha; Transcription activator. Binds to the DNA sequence 5'-AACAAT- 3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling (By similarity). (383 aa)
	nkx6-2	Zinc finger AN1-type containing 1. (281 aa)
	ctnnb1	Dynactin subunit 5. (788 aa)
	selenot	Thioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. Selenoprotein T subfamily. (201 aa)
	PTF1A	Pancreas associated transcription factor 1a. (320 aa)
	gata6	Zinc-finger transcription factor Gata6. (524 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (538 aa)
	ENSXETP00000051440	Uncharacterized protein. (168 aa)
	rfx3	Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (783 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HNF1B	hnf1a	ENSXETP00000028261	ENSXETP00000038904	HNF1 homeobox B.	Heterogeneous nuclear ribonucleoprotein U-like 1.	0.744
HNF1B	pdx1	ENSXETP00000028261	ENSXETP00000011031	HNF1 homeobox B.	Hepatocyte nuclear factor 4, beta.	0.451
LOC108648942	ccdc40	ENSXETP00000024266	ENSXETP00000010617	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4.	Uncharacterized protein.	0.455
MNX1	PTF1A	ENSXETP00000036450	ENSXETP00000050063	Motor neuron and pancreas homeobox 1.	Pancreas associated transcription factor 1a.	0.421
MNX1	RFX6	ENSXETP00000036450	ENSXETP00000028696	Motor neuron and pancreas homeobox 1.	Regulatory factor X6.	0.714
PTF1A	MNX1	ENSXETP00000050063	ENSXETP00000036450	Pancreas associated transcription factor 1a.	Motor neuron and pancreas homeobox 1.	0.421
PTF1A	hnf1a	ENSXETP00000050063	ENSXETP00000038904	Pancreas associated transcription factor 1a.	Heterogeneous nuclear ribonucleoprotein U-like 1.	0.461
PTF1A	pdx1	ENSXETP00000050063	ENSXETP00000011031	Pancreas associated transcription factor 1a.	Hepatocyte nuclear factor 4, beta.	0.635
RFX6	MNX1	ENSXETP00000028696	ENSXETP00000036450	Regulatory factor X6.	Motor neuron and pancreas homeobox 1.	0.714
ccdc40	LOC108648942	ENSXETP00000010617	ENSXETP00000024266	Uncharacterized protein.	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4.	0.455
dlc	dll1	ENSXETP00000023384	ENSXETP00000029635	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.902
dll1	dlc	ENSXETP00000029635	ENSXETP00000023384	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.902
gata6	hnf1a	ENSXETP00000050206	ENSXETP00000038904	Zinc-finger transcription factor Gata6.	Heterogeneous nuclear ribonucleoprotein U-like 1.	0.401
gata6	sox17a	ENSXETP00000050206	ENSXETP00000039437	Zinc-finger transcription factor Gata6.	Transcription factor Sox-17-alpha; Transcription activator. Binds to the DNA sequence 5'-AACAAT- 3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling (By similarity).	0.577
hnf1a	HNF1B	ENSXETP00000038904	ENSXETP00000028261	Heterogeneous nuclear ribonucleoprotein U-like 1.	HNF1 homeobox B.	0.744
hnf1a	PTF1A	ENSXETP00000038904	ENSXETP00000050063	Heterogeneous nuclear ribonucleoprotein U-like 1.	Pancreas associated transcription factor 1a.	0.461
hnf1a	gata6	ENSXETP00000038904	ENSXETP00000050206	Heterogeneous nuclear ribonucleoprotein U-like 1.	Zinc-finger transcription factor Gata6.	0.401
hnf1a	pdx1	ENSXETP00000038904	ENSXETP00000011031	Heterogeneous nuclear ribonucleoprotein U-like 1.	Hepatocyte nuclear factor 4, beta.	0.514
pdx1	HNF1B	ENSXETP00000011031	ENSXETP00000028261	Hepatocyte nuclear factor 4, beta.	HNF1 homeobox B.	0.451
pdx1	PTF1A	ENSXETP00000011031	ENSXETP00000050063	Hepatocyte nuclear factor 4, beta.	Pancreas associated transcription factor 1a.	0.635

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