STRINGSTRING
PDGFC PDGFC STAP1 STAP1 stk11 stk11 alkal2 alkal2 MALT1 MALT1 MAP3K12 MAP3K12 fgf1 fgf1 map3k13 map3k13 FAM20A FAM20A pibf1 pibf1 LOC100490493 LOC100490493 KIF14 KIF14 strada strada dbf4b dbf4b tom1l1 tom1l1 HBEGF HBEGF TGFB2 TGFB2 BTC BTC igf3 igf3 LOC100485626 LOC100485626 wnt11 wnt11 mob1b mob1b p2rx7 p2rx7 irak1 irak1 LOC100490828 LOC100490828 ALKAL1 ALKAL1 camkk2 camkk2 mob1a mob1a itgb1bp1 itgb1bp1 DGKQ DGKQ tirap tirap incenp incenp tgfbr2 tgfbr2 pak2 pak2 BMPR1A BMPR1A LOC100491693 LOC100491693 cks1b cks1b mob2.2 mob2.2 pdgfb-2 pdgfb-2 arhgap26 arhgap26 dtnb-2 dtnb-2 sec62-2 sec62-2 rgcc rgcc wnt11-2 wnt11-2 CCNT2 CCNT2 tgfb1 tgfb1 vegfa vegfa gprc5b gprc5b angpt1 angpt1 parp16 parp16 igf2 igf2 ltk ltk osbpl8 osbpl8 gprc5a gprc5a mob2.1 mob2.1 gprc5cl1 gprc5cl1 zfp91 zfp91 F7ANK9_XENTR F7ANK9_XENTR BORA BORA camkk1 camkk1 LOC100490663 LOC100490663 rptor rptor STRADB STRADB tgfa tgfa CCNT1 CCNT1 cab39 cab39 ccnyl1 ccnyl1 epo epo CCNY CCNY ALK ALK armc9 armc9 epgn epgn ereg ereg areg areg CDK5R1 CDK5R1 spdya spdya lep lep dbf4 dbf4 tent2 tent2 rictor rictor ADRA2B ADRA2B tpx2 tpx2 mob3a mob3a arhgef4-2 arhgef4-2 LOC100496716 LOC100496716 MAP3K7 MAP3K7 nrg1 nrg1 cab39l cab39l traf4 traf4 cks2 cks2 ADNP ADNP CLSPN CLSPN mas1l mas1l MAS1 MAS1 bmpr1b bmpr1b mob3b mob3b LOC100498128 LOC100498128 gas6 gas6 mnat1 mnat1 clec3b-2 clec3b-2 ect2 ect2 pik3ca pik3ca pdpk1 pdpk1 adra2c adra2c prrc1 prrc1 dusp19 dusp19 pcasp3 pcasp3 itgb3 itgb3 abi1 abi1 DAXX DAXX dele1 dele1 ccnk ccnk phb phb wnk3 wnk3 CD40LG CD40LG BMPR2 BMPR2 grem1 grem1 ALS2 ALS2 mob3c mob3c fbn1 fbn1 rplp1 rplp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
STAP1Signal transducing adaptor family member 1. (216 aa)
stk11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
alkal2Huntingtin interacting protein 1 related. (157 aa)
MALT1MALT1 paracaspase. (799 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase. (814 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
map3k13Mitogen-activated protein kinase kinase kinase. (963 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (400 aa)
pibf1Uncharacterized protein. (755 aa)
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1411 aa)
stradaDnaJ homolog subfamily B member 14. (421 aa)
dbf4bDBF4-type domain-containing protein. (836 aa)
tom1l1Uncharacterized protein; Belongs to the TOM1 family. (477 aa)
HBEGFHeparin binding EGF like growth factor. (195 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)
BTCBetacellulin. (170 aa)
igf3Aldehyde dehydrogenase 1 family member B1. (126 aa)
LOC100485626Uncharacterized protein. (406 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
mob1bUncharacterized protein. (217 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (558 aa)
irak1Peroxisomal membrane protein PEX16. (760 aa)
LOC100490828P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (559 aa)
ALKAL1ALK and LTK ligand 1. (168 aa)
camkk2Protein kinase domain-containing protein. (558 aa)
mob1aMOB1, Mps One Binder kinase activator-like 1B. (216 aa)
itgb1bp1Ficolin 1. (209 aa)
DGKQDiacylglycerol kinase. (956 aa)
tirapTIR domain-containing protein. (547 aa)
incenpInner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within [...] (924 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (728 aa)
pak2Non-specific serine/threonine protein kinase. (518 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
LOC100491693TIR domain-containing protein. (505 aa)
cks1bCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
mob2.2MGC79814 protein. (234 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
arhgap26Rho GTPase-activating protein 26; GTPase-activating protein for rhoa and cdc42. (771 aa)
dtnb-2Dystrobrevin beta. (329 aa)
sec62-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (461 aa)
rgccDual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa)
wnt11-2Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N- terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not requ [...] (352 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (771 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
vegfaGID complex subunit 8; Belongs to the PDGF/VEGF growth factor family. (311 aa)
gprc5bBeta-1,3-galactosyltransferase 5-like. (390 aa)
angpt1PWWP domain-containing protein 2A. (504 aa)
parp16Poly [ADP-ribose] polymerase. (318 aa)
igf2IlGF domain-containing protein. (217 aa)
ltkTyrosine-protein kinase receptor. (1126 aa)
osbpl8Oxysterol-binding protein; Belongs to the OSBP family. (966 aa)
gprc5aG_PROTEIN_RECEP_F3_4 domain-containing protein. (362 aa)
mob2.1Uncharacterized loc100145323. (260 aa)
gprc5cl1G_PROTEIN_RECEP_F3_4 domain-containing protein. (432 aa)
zfp91Uncharacterized protein. (501 aa)
F7ANK9_XENTRN-acetyltransferase domain-containing protein. (241 aa)
BORABORA aurora kinase A activator. (601 aa)
camkk1Family with sequence similarity 13 member B. (537 aa)
LOC100490663Uncharacterized protein; Belongs to the protein kinase superfamily. (439 aa)
rptorWD_REPEATS_REGION domain-containing protein. (1356 aa)
STRADBSTE20 related adaptor beta. (419 aa)
tgfaSolute carrier family 6 (neurotransmitter transporter), member 8 like. (163 aa)
CCNT1CYCLIN domain-containing protein; Belongs to the cyclin family. (631 aa)
cab39Cartilage associated protein. (414 aa)
ccnyl1Cyclin-Y-like protein 1; Belongs to the cyclin family. Cyclin Y subfamily. (347 aa)
epoEstrogen related receptor alpha. (183 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
ALKTyrosine-protein kinase receptor. (1258 aa)
armc9LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis (By similarity). (817 aa)
epgnLeucine-rich repeats and calponin homology (CH) domain containing 1. (138 aa)
eregNIMA-related kinase 6. (156 aa)
aregEGF-like domain-containing protein. (226 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (292 aa)
spdyaLOC100127607 protein. (309 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
dbf4Protein DBF4 homolog A; Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit (By similarity). (663 aa)
tent2Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs during oocyte maturation. Plays a central role during oocyte maturation by mediating polyadenylation of dormant mRNAs, which contain 5'AAUAAA-3' sequence in their 3'-UTR. In immature oocytes, polyadenylation of poly(A) tails is counteracted by the ribonuclease parn. During maturation parn is excluded from the ribonucleoprote [...] (492 aa)
rictorSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1. (1707 aa)
ADRA2BAdrenoceptor alpha 2B. (415 aa)
tpx2Targeting protein for Xklp2; Spindle assembly factor. Required for normal assembly of mitotic spindles. Mediates the binding kif15 and aurka to spindle microtubules. Required for targeting kif15 to microtubule minus ends. Activates aurka by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity). Belongs to the TPX2 family. (502 aa)
mob3aMOB1, Mps One Binder kinase activator-like 2A. (216 aa)
arhgef4-2Rho guanine nucleotide exchange factor 4. (455 aa)
LOC100496716Uncharacterized protein. (195 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (594 aa)
nrg1GATA zinc finger domain containing 2A. (621 aa)
cab39lSphingomyelin phosphodiesterase acid-like 3B. (337 aa)
traf4TNF receptor-associated factor. (470 aa)
cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ADNPActivity dependent neuroprotector homeobox. (1093 aa)
CLSPNClaspin. (1219 aa)
mas1lZinc finger protein 276; Belongs to the G-protein coupled receptor 1 family. (331 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (333 aa)
bmpr1bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
mob3bUncharacterized protein. (247 aa)
LOC100498128Gamma-aminobutyric acid (GABA) A receptor, alpha 6. (293 aa)
gas6Homeobox protein CDX-1. (672 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
clec3b-2Uncharacterized protein. (1371 aa)
ect2Survival of motor neuron 1. (987 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
pdpk1Protein kinase domain-containing protein. (554 aa)
adra2cLOC100145449 protein. (433 aa)
prrc1Protein PRRC1. (443 aa)
dusp19Dual specificity phosphatase 19. (215 aa)
pcasp3Uncharacterized protein. (632 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (800 aa)
abi1Uncharacterized protein. (502 aa)
DAXXDeath domain associated protein. (910 aa)
dele1Uncharacterized protein. (563 aa)
ccnkUncharacterized protein; Belongs to the cyclin family. (659 aa)
phbProhibitin. (272 aa)
wnk3Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (269 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa)
grem1Gremlin. (182 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1640 aa)
mob3cTranscription factor Sox-13. (216 aa)
fbn1Abl interactor 1. (2882 aa)
rplp1Ribosomal protein, large, P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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