(35 nodes) Tumor necrosis factor-mediated signaling pathway network (Xenopus tropicalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (290 aa)
	ENSXETP00000000456	Uncharacterized protein. (198 aa)
	tnf	Thyrotropin-releasing hormone receptor 3. (227 aa)
	RELT	Uncharacterized protein. (396 aa)
	traf5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (539 aa)
	usp7-2	Ubiquitin specific peptidase 7 (herpes virus-associated). (316 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (315 aa)
	LOC101732839	Protein kinase domain-containing protein. (580 aa)
	ENSXETP00000011099	Uncharacterized protein. (197 aa)
	bace2-2	Purinergic receptor P2X, ligand gated ion channel, 2. (177 aa)
	ilk	Uncharacterized protein. (286 aa)
	st18	CECR2, histone acetyl-lysine reader. (1007 aa)
	zranb3-2	Zinc finger RAN-binding domain containing 3. (125 aa)
	tpm3	Tropomyosin 3. (197 aa)
	chuk	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (707 aa)
	tnfsf13b	Regulatory factor X associated protein; Belongs to the tumor necrosis factor family. (266 aa)
	traf3ip3	TRAF3 interacting protein 2. (333 aa)
	krt8.1	Keratin 8; Belongs to the intermediate filament family. (508 aa)
	kdm6a-2	Lysine demethylase 6A. (185 aa)
	pycard	Family with sequence similarity 84 member B. (199 aa)
	TRAF2	TNF receptor-associated factor. (481 aa)
	tnfrsf19	POZ/BTB and AT hook containing zinc finger 1. (395 aa)
	eda2r	Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7. (294 aa)
	CARD14	Caspase recruitment domain family member 14. (994 aa)
	plvap	Uncharacterized protein. (366 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (579 aa)
	tnfrsf1a	Uncharacterized protein. (413 aa)
	cdip1	Cell death-inducing p53-target protein 1; May act as a p53/TP53-apoptotic effector. (207 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (260 aa)
	traf6	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (558 aa)
	traf1	TNF receptor-associated factor. (379 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
	ikbkb	Uncharacterized protein. (769 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
	ankhd1-2	Ankyrin repeat and KH domain containing 1. (162 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101732839	TRAF2	ENSXETP00000009360	ENSXETP00000024678	Protein kinase domain-containing protein.	TNF receptor-associated factor.	0.441
LOC101732839	ikbkb	ENSXETP00000009360	ENSXETP00000043650	Protein kinase domain-containing protein.	Uncharacterized protein.	0.881
LOC101732839	nfkbia	ENSXETP00000009360	ENSXETP00000007257	Protein kinase domain-containing protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	0.899
LOC101732839	tnfrsf1a	ENSXETP00000009360	ENSXETP00000034166	Protein kinase domain-containing protein.	Uncharacterized protein.	0.869
LOC101732839	traf1	ENSXETP00000009360	ENSXETP00000039113	Protein kinase domain-containing protein.	TNF receptor-associated factor.	0.441
LOC101732839	traf3	ENSXETP00000009360	ENSXETP00000048669	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.606
LOC101732839	traf6	ENSXETP00000009360	ENSXETP00000036656	Protein kinase domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.598
TNFRSF11A	TNFSF11	ENSXETP00000031852	ENSXETP00000015617	TNF receptor superfamily member 11a.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.997
TNFRSF11A	traf5	ENSXETP00000031852	ENSXETP00000006531	TNF receptor superfamily member 11a.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.457
TNFRSF11A	traf6	ENSXETP00000031852	ENSXETP00000036656	TNF receptor superfamily member 11a.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.793
TNFSF11	TNFRSF11A	ENSXETP00000015617	ENSXETP00000031852	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 11a.	0.997
TNFSF11	tnfsf13b	ENSXETP00000015617	ENSXETP00000018277	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Regulatory factor X associated protein; Belongs to the tumor necrosis factor family.	0.491
TNFSF11	traf6	ENSXETP00000015617	ENSXETP00000036656	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.712
TRAF2	LOC101732839	ENSXETP00000024678	ENSXETP00000009360	TNF receptor-associated factor.	Protein kinase domain-containing protein.	0.441
TRAF2	bace2-2	ENSXETP00000024678	ENSXETP00000011245	TNF receptor-associated factor.	Purinergic receptor P2X, ligand gated ion channel, 2.	0.407
TRAF2	chuk	ENSXETP00000024678	ENSXETP00000017368	TNF receptor-associated factor.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.441
TRAF2	ikbkb	ENSXETP00000024678	ENSXETP00000043650	TNF receptor-associated factor.	Uncharacterized protein.	0.545
TRAF2	tnfrsf1a	ENSXETP00000024678	ENSXETP00000034166	TNF receptor-associated factor.	Uncharacterized protein.	0.857
TRAF2	traf3	ENSXETP00000024678	ENSXETP00000048669	TNF receptor-associated factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.588
TRAF2	traf5	ENSXETP00000024678	ENSXETP00000006531	TNF receptor-associated factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.535

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