STRINGSTRING
LOC100490060 LOC100490060 irf7 irf7 ap1s3 ap1s3 LOC100492034 LOC100492034 mfap4 mfap4 otud4 otud4 ado-2 ado-2 GRAMD4 GRAMD4 Cxorf21 Cxorf21 irf1 irf1 pja2 pja2 cyba cyba cav3.1 cav3.1 esr1 esr1 cav1 cav1 CACTIN CACTIN cyb5b-2 cyb5b-2 rsad2 rsad2 appl1 appl1 nfkbil1 nfkbil1 tlr3 tlr3 ENSXETP00000021509 ENSXETP00000021509 lgr4 lgr4 nr1d1 nr1d1 ACOD1 ACOD1 rab7b rab7b LRRC14 LRRC14 ifi35 ifi35 LOC733765 LOC733765 acod1lb acod1lb appl2 appl2 tirap tirap peli2 peli2 sarm1 sarm1 smpdl3b smpdl3b LOC100491693 LOC100491693 cav3.2 cav3.2 lyn lyn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100490060CD274 molecule. (498 aa)
irf7Dipeptidyl-peptidase 10 (inactive). (388 aa)
ap1s3Uncharacterized protein. (533 aa)
LOC100492034Endosome-associated-trafficking regulator 1. (291 aa)
mfap4Pancreatic lipase-related protein 3. (881 aa)
otud4Suppressor of cancer cell invasion. (1051 aa)
ado-22-aminoethanethiol (cysteamine) dioxygenase. (378 aa)
GRAMD4GRAM domain containing 4. (592 aa)
Cxorf21Chromosome 17 open reading frame 53. (299 aa)
irf1Interferon regulatory factor. (302 aa)
pja2F-box protein 30. (779 aa)
cybaCytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (187 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
CACTINCactin, spliceosome C complex subunit. (797 aa)
cyb5b-2Cytochrome b5 type B (outer mitochondrial membrane); Belongs to the Toll-like receptor family. (1024 aa)
rsad2Proteasome subunit alpha 2. (393 aa)
appl1K(lysine) acetyltransferase 8. (685 aa)
nfkbil1ANK_REP_REGION domain-containing protein. (387 aa)
tlr3TIR domain-containing protein; Belongs to the Toll-like receptor family. (917 aa)
ENSXETP00000021509Uncharacterized protein. (370 aa)
lgr4Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (956 aa)
nr1d1Heparan sulfate 6-O-sulfotransferase 3. (529 aa)
ACOD1Aconitate decarboxylase 1. (474 aa)
rab7bUncharacterized protein. (201 aa)
LRRC14Uncharacterized protein. (596 aa)
ifi35DnaJ heat shock protein family (Hsp40) member C4. (368 aa)
LOC733765Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
acod1lbCentromere protein K. (498 aa)
appl2Alveolar soft part sarcoma chromosome region, candidate 1. (664 aa)
tirapTIR domain-containing protein. (547 aa)
peli2PHD finger protein 5A. (418 aa)
sarm1KRR1, small subunit (SSU) processome component, homolog. (719 aa)
smpdl3bAcid sphingomyelinase-like phosphodiesterase; Belongs to the acid sphingomyelinase family. (455 aa)
LOC100491693TIR domain-containing protein. (505 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
lynTyrosine-protein kinase. (524 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.