STRINGSTRING
NLRC3 NLRC3 tp53 tp53 RIPK2 RIPK2 DOCK8 DOCK8 DLL4 DLL4 CD276 CD276 gm2a-2 gm2a-2 dpp4 dpp4 FGL2 FGL2 cldn5-2 cldn5-2 tbx21 tbx21 bcl11b bcl11b eif2ak4 eif2ak4 cxadr cxadr lepr lepr itch itch RC3H1 RC3H1 pcasp3 pcasp3 ENSXETP00000046118 ENSXETP00000046118 ncstn ncstn sash3 sash3 il4r il4r gata3 gata3 lrrc1 lrrc1 Wdfy4 Wdfy4 F7C1U7_XENTR F7C1U7_XENTR ctnnb1 ctnnb1 ENSXETP00000006089 ENSXETP00000006089 F7CYZ3_XENTR F7CYZ3_XENTR NKX2-3 NKX2-3 usp7-2 usp7-2 armc5 armc5 bax bax ada ada gpr89b gpr89b ada.2 ada.2 LOC100495707 LOC100495707 anxa1.3 anxa1.3 lef1 lef1 bace2-2 bace2-2 ENSXETP00000011401 ENSXETP00000011401 polr3b-2 polr3b-2 rag2 rag2 p2rx7 p2rx7 LOC100490828 LOC100490828 PAX1 PAX1 LOC100488475 LOC100488475 LOC101731187 LOC101731187 psen1 psen1 zbtb1 zbtb1 JAG2 JAG2 eomes eomes AZI2 AZI2 batf batf stoml2 stoml2 LOC100492690 LOC100492690 LOC100491070 LOC100491070 cd74 cd74 rsad2 rsad2 srf srf ptpn6 ptpn6 tnfsf13b tnfsf13b LOC100487470 LOC100487470 stat3.2 stat3.2 cdh26 cdh26 stat3.1 stat3.1 traf3ip3 traf3ip3 hspd1 hspd1 rabl3 rabl3 sla2 sla2 SCRIB SCRIB tgfb1 tgfb1 rhoh rhoh FOXP3 FOXP3 rorc rorc ENSXETP00000022548 ENSXETP00000022548 tspan32 tspan32 jmjd6 jmjd6 CCR7 CCR7 Il6 Il6 cd28 cd28 CCR9 CCR9 gli3 gli3 crip3 crip3 fadd fadd msn msn LOC100490663 LOC100490663 ebna1bp2-4 ebna1bp2-4 cd3g cd3g ubn1-2 ubn1-2 HSH2D HSH2D PSMB11 PSMB11 pknox1 pknox1 rab29 rab29 rora rora tsc1 tsc1 fzd5 fzd5 fzd8 fzd8 kit kit peli2 peli2 ENSXETP00000031491 ENSXETP00000031491 BRAF BRAF BCL2 BCL2 mtor mtor anxa1.1 anxa1.1 lep lep ENSXETP00000033234 ENSXETP00000033234 ABL1 ABL1 sp3 sp3 PRR7 PRR7 atg5 atg5 tmem98 tmem98 ENSXETP00000034825 ENSXETP00000034825 nck1 nck1 abl2 abl2 zap70 zap70 ENSXETP00000036481 ENSXETP00000036481 rag1 rag1 foxn1 foxn1 ptger4 ptger4 syk syk TOX TOX tcf7 tcf7 ebi3 ebi3 IKZF3 IKZF3 hlx hlx ENSXETP00000039406 ENSXETP00000039406 GPR18 GPR18 sema4a sema4a IL18R1 IL18R1 ptpn2 ptpn2 lig4 lig4 fkbp1b fkbp1b stk11 stk11 WNT1 WNT1 MALT1 MALT1 irf1 irf1 LOC100490493 LOC100490493
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NLRC3NLR family CARD domain containing 3. (910 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (408 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2040 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
CD276CD276 molecule. (332 aa)
gm2a-2GM2 ganglioside activator. (587 aa)
dpp4Uncharacterized protein; Belongs to the peptidase S9B family. (837 aa)
FGL2Fibrinogen like 2. (429 aa)
cldn5-2Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome). (421 aa)
tbx21Leucine rich repeat containing 3B. (561 aa)
bcl11bAquaporin 7. (829 aa)
eif2ak4Uncharacterized protein. (1668 aa)
cxadrUncharacterized protein. (362 aa)
leprLeucine-rich repeat-containing protein 42. (1138 aa)
itchE3 ubiquitin-protein ligase. (853 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
pcasp3Uncharacterized protein. (632 aa)
ENSXETP00000046118DDE_Tnp_1_7 domain-containing protein. (597 aa)
ncstnCathepsin G. (592 aa)
sash3Novel protein similar to sly (CXorf9). (389 aa)
il4rMesenteric estrogen-dependent adipogenesis. (934 aa)
gata3Uncharacterized protein. (454 aa)
lrrc1Uncharacterized protein. (508 aa)
Wdfy4Uncharacterized protein. (542 aa)
F7C1U7_XENTRUncharacterized protein. (1475 aa)
ctnnb1Dynactin subunit 5. (788 aa)
ENSXETP00000006089Ig-like domain-containing protein. (369 aa)
F7CYZ3_XENTRUncharacterized protein. (224 aa)
NKX2-3Homeobox domain-containing protein. (328 aa)
usp7-2Ubiquitin specific peptidase 7 (herpes virus-associated). (316 aa)
armc5BTB domain-containing protein. (934 aa)
baxBCL2-associated X protein. (221 aa)
adaAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (359 aa)
gpr89bUncharacterized protein. (462 aa)
ada.2A_deaminase domain-containing protein. (415 aa)
LOC100495707Fibrinogen C-terminal domain-containing protein. (379 aa)
anxa1.3Annexin. (350 aa)
lef1HMG box domain-containing protein. (415 aa)
bace2-2Purinergic receptor P2X, ligand gated ion channel, 2. (177 aa)
ENSXETP00000011401DDE_Tnp_1_7 domain-containing protein. (460 aa)
polr3b-2Uncharacterized protein. (271 aa)
rag2ABI family member 3 binding protein. (520 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (558 aa)
LOC100490828P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (559 aa)
PAX1Paired box 1. (357 aa)
LOC100488475Uncharacterized protein. (224 aa)
LOC101731187Rho guanine nucleotide exchange factor 3. (265 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
zbtb1CCR4-NOT transcription complex subunit 6-like. (685 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1133 aa)
eomesAutophagy related 12. (674 aa)
AZI25-azacytidine induced 2. (372 aa)
batfBasic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells; Belongs to the bZIP family. (115 aa)
stoml2PHB domain-containing protein. (341 aa)
LOC100492690Eukaryotic translation initiation factor 3 subunit F. (856 aa)
LOC100491070Uncharacterized protein. (469 aa)
cd74Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
rsad2Proteasome subunit alpha 2. (393 aa)
srfHydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (359 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
tnfsf13bRegulatory factor X associated protein; Belongs to the tumor necrosis factor family. (266 aa)
LOC100487470DDE_Tnp_1_7 domain-containing protein. (610 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
cdh26Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
traf3ip3TRAF3 interacting protein 2. (333 aa)
hspd1Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (599 aa)
rabl3Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (149 aa)
sla2Kelch like family member 30. (269 aa)
SCRIBScribble planar cell polarity protein. (945 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
rhohLOC100145522 protein. (190 aa)
FOXP3Forkhead box P3. (412 aa)
rorcNR LBD domain-containing protein. (397 aa)
ENSXETP00000022548IL12p40_C domain-containing protein. (249 aa)
tspan32Caseinolytic mitochondrial matrix peptidase proteolytic subunit; Belongs to the tetraspanin (TM4SF) family. (261 aa)
jmjd6JmjC domain-containing protein. (403 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (358 aa)
Il6Uncharacterized protein. (150 aa)
cd28Cd28 protein. (210 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (368 aa)
gli3Centrosomal protein 164kDa. (1566 aa)
crip3IQ motif and Sec7 domain 3. (138 aa)
faddZinc finger, NFX1-type containing 1, gene 2. (188 aa)
msnHomogentisate 1,2-dioxygenase. (591 aa)
LOC100490663Uncharacterized protein; Belongs to the protein kinase superfamily. (439 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
cd3gIg_4 domain-containing protein. (164 aa)
ubn1-2Ubinuclein 1. (172 aa)
HSH2DHematopoietic SH2 domain containing. (363 aa)
PSMB11Proteasome subunit beta. (288 aa)
pknox1Homeobox domain-containing protein. (348 aa)
rab29LOC100135159 protein. (204 aa)
roraPotassium channel, two pore domain subfamily K, member 4. (518 aa)
tsc1Distal-less homeobox 1. (1139 aa)
fzd5Zinc finger DHHC-type containing 9; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
fzd8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
peli2PHD finger protein 5A. (418 aa)
ENSXETP00000031491Enhancer of polycomb homolog 1. (455 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2534 aa)
anxa1.1Annexin. (675 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
ENSXETP00000033234annotation not available (481 aa)
ABL1Tyrosine-protein kinase. (1128 aa)
sp3Zona pellucida glycoprotein 3 (sperm receptor), gene 2. (731 aa)
PRR7Proline rich 7, synaptic. (260 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
tmem98LOC100145240 protein. (226 aa)
ENSXETP00000034825Uncharacterized protein. (666 aa)
nck1Cytoplasmic protein. (377 aa)
abl2Tyrosine-protein kinase. (1100 aa)
zap70Tyrosine-protein kinase. (609 aa)
ENSXETP00000036481annotation not available (401 aa)
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (584 aa)
foxn1Diphthamide biosynthesis 5. (583 aa)
ptger4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
sykTyrosine-protein kinase. (611 aa)
TOXThymocyte selection associated high mobility group box. (537 aa)
tcf7HMG box domain-containing protein. (488 aa)
ebi3Beta-1,4-glucuronyltransferase 1. (188 aa)
IKZF3IKAROS family zinc finger 3. (504 aa)
hlxCytosol aminopeptidase. (328 aa)
ENSXETP00000039406annotation not available (454 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
sema4aSema domain-containing protein; Belongs to the semaphorin family. (681 aa)
IL18R1Interleukin 18 receptor 1. (395 aa)
ptpn2Proteasome 26S subunit, non-ATPase 8. (498 aa)
lig4DNA ligase. (911 aa)
fkbp1bPeptidylprolyl isomerase. (108 aa)
stk11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
MALT1MALT1 paracaspase. (799 aa)
irf1Interferon regulatory factor. (302 aa)
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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