STRINGSTRING
tnfsf13b tnfsf13b nbn nbn tpd52 tpd52 ENSXETP00000054108 ENSXETP00000054108 txlna txlna adhfe1 adhfe1 ENSXETP00000051440 ENSXETP00000051440 CD40LG CD40LG phb phb def6 def6 pcasp3 pcasp3 exo1 exo1 sash3 sash3 MSH6 MSH6 MSH2 MSH2 kiaa1841 kiaa1841 tp53 tp53 itm2a itm2a lyl1 lyl1 dnajb9 dnajb9 ATM ATM IKZF3 IKZF3 syk syk ung ung rag1 rag1 ENSXETP00000035998 ENSXETP00000035998 lgals1.2 lgals1.2 lgals1.4 lgals1.4 ENSXETP00000034089 ENSXETP00000034089 sp3 sp3 prkcb prkcb Dock10 Dock10 ccdc122 ccdc122 ENSXETP00000032267 ENSXETP00000032267 BCL2 BCL2 ENSXETP00000031154 ENSXETP00000031154 dcaf1 dcaf1 cdh17 cdh17 kit kit dll1 dll1 cebpg cebpg EXOSC3 EXOSC3 fnip1 fnip1 ebna1bp2-4 ebna1bp2-4 lfng lfng rnf8 rnf8 dlc dlc FOXP3 FOXP3 rabl3 rabl3 ercc1 ercc1 CXCR5 CXCR5 traf3ip3 traf3ip3 rnf168 rnf168 batf batf ntrk1 ntrk1 zbtb1 zbtb1 mlh1 mlh1 lrrc8a lrrc8a rag2 rag2 lgals1.1 lgals1.1 atp6v0a2-2 atp6v0a2-2 lgals1.3 lgals1.3 cd40 cd40 gmpr2-2 gmpr2-2 bbs4-2 bbs4-2 dock10 dock10 znf180-2 znf180-2 lef1 lef1 ptk7 ptk7 lcp2 lcp2 LOC105945198 LOC105945198 ENSXETP00000010053 ENSXETP00000010053 cd79a cd79a bax bax ENSXETP00000008614 ENSXETP00000008614 tmub2-2 tmub2-2 gon4l gon4l usp7-2 usp7-2 NKX2-3 NKX2-3 F7CYZ3_XENTR F7CYZ3_XENTR ep300 ep300 stac stac ENSXETP00000003176 ENSXETP00000003176 MALT1 MALT1 skap2 skap2 itfg2 itfg2 cmtm7 cmtm7 atad5 atad5 clcf1 clcf1 ENSXETP00000001570 ENSXETP00000001570 lig4 lig4 ptpn2 ptpn2 kdelr2-2 kdelr2-2 rad1-2 rad1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnfsf13bRegulatory factor X associated protein; Belongs to the tumor necrosis factor family. (266 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (806 aa)
tpd52Uncharacterized protein. (219 aa)
ENSXETP00000054108RNase_PH domain-containing protein. (199 aa)
txlnaUncharacterized protein. (515 aa)
adhfe1Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (544 aa)
ENSXETP00000051440Uncharacterized protein. (168 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (269 aa)
phbProhibitin. (272 aa)
def6DEF6 guanine nucleotide exchange factor. (596 aa)
pcasp3Uncharacterized protein. (632 aa)
exo1Ubiquitin-fold modifier conjugating enzyme 1. (736 aa)
sash3Novel protein similar to sly (CXorf9). (389 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1340 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
kiaa1841Polo-like kinase 2. (716 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
itm2aGlucose-6-phosphate isomerase. (247 aa)
lyl1Sosondowah ankyrin repeat domain family member C. (388 aa)
dnajb9Dnajb9 protein. (221 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
IKZF3IKAROS family zinc finger 3. (504 aa)
sykTyrosine-protein kinase. (611 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (360 aa)
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (584 aa)
ENSXETP00000035998RNase_PH domain-containing protein. (207 aa)
lgals1.2Galectin. (135 aa)
lgals1.4Galectin. (126 aa)
ENSXETP00000034089RNase_PH domain-containing protein. (188 aa)
sp3Zona pellucida glycoprotein 3 (sperm receptor), gene 2. (731 aa)
prkcbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (671 aa)
Dock10PH domain-containing protein. (498 aa)
ccdc122WD repeat domain 36. (208 aa)
ENSXETP00000032267Type I interferon 5. (189 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
ENSXETP00000031154B cell linker. (489 aa)
dcaf1NADPH oxidase 4. (1503 aa)
cdh17Retinol binding protein 3. (830 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
cebpgCCAAT/enhancer binding protein (C/EBP), gamma. (137 aa)
EXOSC3Exosome component 3. (250 aa)
fnip1cAMP-responsive element modulator. (1163 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
lfngBeta-1,3-N-acetylglucosaminyltransferase. (372 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (535 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
FOXP3Forkhead box P3. (412 aa)
rabl3Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (149 aa)
ercc1Uncharacterized protein. (302 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
traf3ip3TRAF3 interacting protein 2. (333 aa)
rnf168E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (542 aa)
batfBasic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells; Belongs to the bZIP family. (115 aa)
ntrk1Tyrosine-protein kinase receptor. (808 aa)
zbtb1CCR4-NOT transcription complex subunit 6-like. (685 aa)
mlh1Mitochondrial ribosomal protein L1. (758 aa)
lrrc8aCWC27 spliceosome-associated protein. (809 aa)
rag2ABI family member 3 binding protein. (520 aa)
lgals1.1Galectin. (134 aa)
atp6v0a2-2Reticulophagy regulator family member 2. (201 aa)
lgals1.3Galectin. (135 aa)
cd40CD40. (279 aa)
gmpr2-2Guanosine monophosphate reductase 2. (190 aa)
bbs4-2RNase_PH domain-containing protein. (221 aa)
dock10DHR-2 domain-containing protein; Belongs to the DOCK family. (433 aa)
znf180-2Zinc finger protein 180. (153 aa)
lef1HMG box domain-containing protein. (415 aa)
ptk7Protein tyrosine kinase 7 (inactive). (697 aa)
lcp2LOC100158590 protein. (504 aa)
LOC105945198Type I interferon 4. (189 aa)
ENSXETP00000010053Uncharacterized protein. (186 aa)
cd79aUrocanate hydratase 1. (239 aa)
baxBCL2-associated X protein. (221 aa)
ENSXETP00000008614Uncharacterized protein. (162 aa)
tmub2-2Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (661 aa)
gon4lUncharacterized protein. (1817 aa)
usp7-2Ubiquitin specific peptidase 7 (herpes virus-associated). (316 aa)
NKX2-3Homeobox domain-containing protein. (328 aa)
F7CYZ3_XENTRUncharacterized protein. (224 aa)
ep300Suv3 like RNA helicase. (2493 aa)
stacSH3 and cysteine rich domain. (220 aa)
ENSXETP00000003176RNase_PH domain-containing protein. (228 aa)
MALT1MALT1 paracaspase. (799 aa)
skap2Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. May play a role in src signaling pathway (By similarity). (328 aa)
itfg2Uncharacterized protein. (441 aa)
cmtm7MGC107754 protein. (165 aa)
atad5Dipeptidyl-peptidase 6. (1728 aa)
clcf1Cardiotrophin-like cytokine factor 1. (223 aa)
ENSXETP00000001570Mediator of RNA polymerase II transcription subunit 8. (574 aa)
lig4DNA ligase. (911 aa)
ptpn2Proteasome 26S subunit, non-ATPase 8. (498 aa)
kdelr2-2ER lumen protein-retaining receptor 2. (205 aa)
rad1-2RAD1 checkpoint DNA exonuclease. (162 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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