(103 nodes) Glucose homeostasis network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cpb2	MGC108395 protein. (421 aa)
	ptpn2	Proteasome 26S subunit, non-ATPase 8. (498 aa)
	rab11fip5	Uncharacterized protein. (1534 aa)
	Crtc2	TORC_N domain-containing protein. (54 aa)
	stk11	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
	ccdc186	Uncharacterized protein. (878 aa)
	LOC101730668	ABC transporter domain-containing protein. (310 aa)
	nox4	Short chain dehydrogenase/reductase family 16C member 5. (583 aa)
	prcp	Uncharacterized protein. (496 aa)
	HK2	Hexokinase 2. (937 aa)
	cry1	Forkhead box protein F1. (616 aa)
	pax6	Uncharacterized protein. (456 aa)
	c1qtnf9b	HECT domain containing E3 ubiquitin protein ligase 3. (244 aa)
	csrp3	Cysteine and glycine-rich protein 2. (194 aa)
	CRY2	Cryptochrome circadian regulator 2. (662 aa)
	adipoq	Collagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive). (235 aa)
	mlxipl	Neuronal pentraxin receptor. (861 aa)
	ffar3	Amylase, alpha 2B (pancreatic); Belongs to the G-protein coupled receptor 1 family. (322 aa)
	FFAR2	Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	dhps	Uncharacterized protein. (356 aa)
	pdx1	Hepatocyte nuclear factor 4, beta. (271 aa)
	rab11fip2	LOC100127577 protein. (518 aa)
	lrrc8a	CWC27 spliceosome-associated protein. (809 aa)
	slc8b1	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
	pdhx-2	Oxysterol binding protein like 10. (49 aa)
	appl2	Alveolar soft part sarcoma chromosome region, candidate 1. (664 aa)
	xbp1	Destrin, actin depolymerizing factor. (349 aa)
	slc39a14	Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. (470 aa)
	sirt6	Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
	gucy2f-2	Guanylate cyclase 2F, retinal; Belongs to the G-protein coupled receptor 2 family. (515 aa)
	ENSXETP00000018846	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (441 aa)
	stat3.2	STAT_int domain-containing protein. (408 aa)
	adgrf1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; Belongs to the G-protein coupled receptor 2 family. (1231 aa)
	stat3.1	Signal transducer and activator of transcription. (715 aa)
	dtnb-2	Dystrobrevin beta. (329 aa)
	pck1	Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6. (622 aa)
	MGC145330	Protein phosphatase 1 regulatory subunit 12C. (114 aa)
	tra2b	Ras-like without CAAX 1. (324 aa)
	mbd6	Signal peptide, CUB domain, EGF-like 1. (1365 aa)
	znf420-2	Zinc finger protein 420. (128 aa)
	dbh	Ectodermal-neural cortex (with BTB-like domain), gene 2. (615 aa)
	wfs1	LOC100127642 protein. (863 aa)
	foxk2	Fork-head domain-containing protein. (604 aa)
	stxbp3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (589 aa)
	cry4	WD repeat containing, antisense to TP73. (567 aa)
	adipor1	Adiponectin receptor 1. (379 aa)
	sesn2	Uncharacterized protein. (415 aa)
	rph3al	Uncharacterized protein. (351 aa)
	Il6	Uncharacterized protein. (150 aa)
	nr1d1	Heparan sulfate 6-O-sulfotransferase 3. (529 aa)
	dcaf8	DDB1- and CUL4-associated factor 8. (604 aa)
	slc37a4	MFS domain-containing protein. (505 aa)
	gpi	Glucose-6-phosphate isomerase; Belongs to the GPI family. (597 aa)
	hk1	Uncharacterized protein. (920 aa)
	aspscr1	Cleavage and polyadenylation specific factor 3. (590 aa)
	RFX6	Regulatory factor X6. (931 aa)
	nucks1	Nuclear casein kinase and cyclin-dependent kinase substrate 1. (291 aa)
	nradd	High mobility group box 3. (390 aa)
	klf7	Kruppel-like factor 7 (Ubiquitous). (296 aa)
	macrod1	MACRO domain containing 1; Belongs to the G-protein coupled receptor 1 family. (294 aa)
	LOC100485245	Rgd1566381; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	stk11ip-2	Serine/threonine-protein kinase 11-interacting protein; Belongs to the G-protein coupled receptor 1 family. (317 aa)
	foxo1	Forkhead box protein O1; Transcription factor. (626 aa)
	adprm-2	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase. (317 aa)
	znf236	G protein-coupled receptor 89B. (1818 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	hectd4	Acidic nuclear phosphoprotein 32 family member E. (4388 aa)
	park7	Parkinson disease (Autosomal recessive,). (189 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (724 aa)
	ENSXETP00000034825	Uncharacterized protein. (666 aa)
	ncoa5	Nuclear receptor coactivator 5. (625 aa)
	LOC100485335	Poly(A) polymerase alpha. (281 aa)
	bad	SMC5-SMC6 complex localization factor 1. (151 aa)
	pck2	Phosphoenolpyruvate carboxykinase 1, cytosolic. (604 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (571 aa)
	fgfr4	Fibroblast growth factor receptor. (833 aa)
	cyp7a1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
	LOC100492955	Phosphotransferase. (600 aa)
	bhlha15	Zinc finger protein 423. (175 aa)
	ENSXETP00000041863	Uncharacterized protein. (431 aa)
	acvr2b-2	Activin A receptor type 2B. (37 aa)
	inpp5k	IPPc domain-containing protein. (547 aa)
	gas6	Homeobox protein CDX-1. (672 aa)
	cartpt	Uncharacterized protein. (113 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (637 aa)
	gper1	Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	selenot	Thioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. Selenoprotein T subfamily. (201 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
	cry-dash	Family with sequence similarity 92 member B. (445 aa)
	rack1	Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1. (317 aa)
	rmi1	DUF1767 domain-containing protein. (509 aa)
	lepr	Leucine-rich repeat-containing protein 42. (1138 aa)
	hk2	Mannosyl-oligosaccharide glucosidase. (937 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (564 aa)
	sirt1	Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
	wnk3	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
	nr1h4	Protein phosphatase 5, catalytic subunit. (458 aa)
	gck	Phosphotransferase. (458 aa)
	PTCH1	Patched 1. (1430 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (274 aa)
	lrrc8d	LOC100145421 protein. (855 aa)
	GPR1	G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (202 aa)
	fbn1	Abl interactor 1. (2882 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRY2	cry-dash	ENSXETP00000007316	ENSXETP00000045094	Cryptochrome circadian regulator 2.	Family with sequence similarity 92 member B.	0.835
CRY2	cry1	ENSXETP00000007316	ENSXETP00000004587	Cryptochrome circadian regulator 2.	Forkhead box protein F1.	0.745
CRY2	cry4	ENSXETP00000007316	ENSXETP00000023570	Cryptochrome circadian regulator 2.	WD repeat containing, antisense to TP73.	0.750
CRY2	nr1d1	ENSXETP00000007316	ENSXETP00000024960	Cryptochrome circadian regulator 2.	Heparan sulfate 6-O-sulfotransferase 3.	0.606
ENSXETP00000034825	lep	ENSXETP00000034825	ENSXETP00000033039	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.654
HK2	gck	ENSXETP00000004467	ENSXETP00000050089	Hexokinase 2.	Phosphotransferase.	0.903
HK2	gpi	ENSXETP00000004467	ENSXETP00000025771	Hexokinase 2.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.969
HK2	hk1	ENSXETP00000004467	ENSXETP00000026987	Hexokinase 2.	Uncharacterized protein.	0.901
HK2	hk2	ENSXETP00000004467	ENSXETP00000047669	Hexokinase 2.	Mannosyl-oligosaccharide glucosidase.	0.902
Il6	adipoq	ENSXETP00000024453	ENSXETP00000007732	Uncharacterized protein.	Collagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive).	0.589
Il6	c1qtnf9b	ENSXETP00000024453	ENSXETP00000004878	Uncharacterized protein.	HECT domain containing E3 ubiquitin protein ligase 3.	0.406
Il6	lep	ENSXETP00000024453	ENSXETP00000033039	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.596
Il6	stat3.1	ENSXETP00000024453	ENSXETP00000019558	Uncharacterized protein.	Signal transducer and activator of transcription.	0.539
Il6	stat3.2	ENSXETP00000024453	ENSXETP00000018942	Uncharacterized protein.	STAT_int domain-containing protein.	0.539
LOC100492955	gpi	ENSXETP00000040998	ENSXETP00000025771	Phosphotransferase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.703
RFX6	mlxipl	ENSXETP00000028696	ENSXETP00000008473	Regulatory factor X6.	Neuronal pentraxin receptor.	0.585
adipoq	Il6	ENSXETP00000007732	ENSXETP00000024453	Collagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive).	Uncharacterized protein.	0.589
adipoq	adipor1	ENSXETP00000007732	ENSXETP00000023588	Collagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive).	Adiponectin receptor 1.	0.983
adipoq	appl2	ENSXETP00000007732	ENSXETP00000016472	Collagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive).	Alveolar soft part sarcoma chromosome region, candidate 1.	0.728
adipoq	c1qtnf9b	ENSXETP00000007732	ENSXETP00000004878	Collagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive).	HECT domain containing E3 ubiquitin protein ligase 3.	0.904

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