(76 nodes) Negative regulation of ion transport network (Xenopus tropicalis)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	wnk2	Guanine nucleotide binding protein (G protein), alpha 13. (1752 aa)
	LOC100489234	Peptidase M60 domain-containing protein. (1561 aa)
	sri	Sorcin. (195 aa)
	LOC100489857	Anoctamin. (594 aa)
	kcne5	Uncharacterized protein. (103 aa)
	kcne3	Nebulin. (99 aa)
	slc43a1	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4. (543 aa)
	hecw1	RAB3A interacting protein. (1586 aa)
	Kcne1	Uncharacterized protein. (128 aa)
	slc30a1	Solute carrier family 30 (Zinc transporter), member 1. (493 aa)
	arl6ip5	PRA1 family protein. (188 aa)
	pacsin3	Sulfotransferase family 6B member 1 gene 4. (457 aa)
	gem	Pleckstrin homology and FYVE domain containing 2. (299 aa)
	mmp9.1	Uncharacterized protein. (692 aa)
	wnk4	Uncharacterized protein. (691 aa)
	LOC101733206	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (226 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (162 aa)
	nedd4	E3 ubiquitin-protein ligase. (896 aa)
	fmr1	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787. (590 aa)
	LOC733765	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	stk39	Serine threonine kinase 39 (STE20/SPS1 homolog). (526 aa)
	LOC100490855	Uncharacterized protein. (627 aa)
	LOC101732772	Anoctamin. (647 aa)
	ENSXETP00000017381	Anoctamin. (569 aa)
	ENSXETP00000017403	Anoctamin. (620 aa)
	LOC101732476	Anoctamin. (634 aa)
	atf4	Activating transcription factor 4 (Tax-responsive enhancer element B67). (343 aa)
	serpine2	SERPIN domain-containing protein; Belongs to the serpin family. (424 aa)
	LOC101735172	Uncharacterized protein. (425 aa)
	cbarp	LOC100124991 protein. (732 aa)
	rem1	Rem1 protein. (279 aa)
	ENSXETP00000022583	Uncharacterized protein. (113 aa)
	ENSXETP00000022765	Uncharacterized protein. (105 aa)
	LOC100485132	Sulfite oxidase. (899 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	gopc	PDZ domain-containing protein. (546 aa)
	epo	Estrogen related receptor alpha. (183 aa)
	tmtc3-2	Transmembrane and tetratricopeptide repeat containing 3. (152 aa)
	BCL2	BCL2 apoptosis regulator. (293 aa)
	cntd1	Aquaporin 9. (277 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (119 aa)
	Syt11	Synaptotagmin 11. (295 aa)
	pkd2	Ubiquitin carboxyl-terminal hydrolase 33. (951 aa)
	kcnrg	Putative potassium channel regulatory protein; Inhibits potassium fluxes in cells, possibly by retaining potassium channels in the cytoplasm. (279 aa)
	nedd4l	Nitric oxide synthase 2. (1290 aa)
	LOC100496423	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	cav3.2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	pxk	Protein Spindly. (726 aa)
	SLN	Sarcolipin. (31 aa)
	inpp5k	IPPc domain-containing protein. (547 aa)
	VIP	Vasoactive intestinal peptide. (202 aa)
	tcaf1	Peptidase M60 domain-containing protein. (905 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (684 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (414 aa)
	commd1	Protein serine kinase H1. (187 aa)
	rrad	MAP/microtubule affinity-regulating kinase 4. (303 aa)
	WNK3	Protein kinase domain-containing protein. (1624 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
	oxsr1	Homeodomain interacting protein kinase 3. (639 aa)
	trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (226 aa)
	slc22a15.2	Solute carrier family 22 member 15-like; Probably transports organic cations; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (487 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	stc1	Serine/threonine kinase 16. (247 aa)
	SLC26A5	Solute carrier family 26 member 5. (803 aa)
	WNK1	Uncharacterized protein. (2206 aa)
	Hrh4.f5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (129 aa)
	Hrh4.f7	G_PROTEIN_RECEP_F1_2 domain-containing protein. (69 aa)
	adgra2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (82 aa)
	Hrh4.f1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (199 aa)
	LOC101734803	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	ube3a-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (429 aa)
	dctd-2	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (387 aa)
	F7BV19_XENTR	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	znf703-2	Chromosome 14 open reading frame 119; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	nphs1	NPHS1 nephrin; Belongs to the G-protein coupled receptor 1 family. (402 aa)
	gnb5	TATA-box binding protein associated factor 13. (395 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	mmp9.1	ENSXETP00000032076	ENSXETP00000010213	BCL2 apoptosis regulator.	Uncharacterized protein.	0.558
BCL2	rem1	ENSXETP00000032076	ENSXETP00000022411	BCL2 apoptosis regulator.	Rem1 protein.	0.513
KCNE2	KCNE4	ENSXETP00000033059	ENSXETP00000014333	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.796
KCNE2	kcne3	ENSXETP00000033059	ENSXETP00000003768	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Nebulin.	0.656
KCNE4	KCNE2	ENSXETP00000014333	ENSXETP00000033059	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.796
KCNE4	Kcne1	ENSXETP00000014333	ENSXETP00000005788	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Uncharacterized protein.	0.457
KCNE4	kcne3	ENSXETP00000014333	ENSXETP00000003768	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Nebulin.	0.606
Kcne1	KCNE4	ENSXETP00000005788	ENSXETP00000014333	Uncharacterized protein.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.457
Kcne1	kcne3	ENSXETP00000005788	ENSXETP00000003768	Uncharacterized protein.	Nebulin.	0.591
LOC733765	cav1	ENSXETP00000016352	ENSXETP00000048942	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
LOC733765	cav3.1	ENSXETP00000016352	ENSXETP00000046948	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
LOC733765	cav3.2	ENSXETP00000016352	ENSXETP00000039803	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
PLN	SLN	ENSXETP00000027366	ENSXETP00000041702	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	Sarcolipin.	0.711
SLN	PLN	ENSXETP00000041702	ENSXETP00000027366	Sarcolipin.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.711
WNK1	oxsr1	ENSXETP00000050679	ENSXETP00000048476	Uncharacterized protein.	Homeodomain interacting protein kinase 3.	0.541
WNK1	stk39	ENSXETP00000050679	ENSXETP00000016637	Uncharacterized protein.	Serine threonine kinase 39 (STE20/SPS1 homolog).	0.541
WNK3	oxsr1	ENSXETP00000046555	ENSXETP00000048476	Protein kinase domain-containing protein.	Homeodomain interacting protein kinase 3.	0.552
WNK3	stk39	ENSXETP00000046555	ENSXETP00000016637	Protein kinase domain-containing protein.	Serine threonine kinase 39 (STE20/SPS1 homolog).	0.552
cav1	LOC733765	ENSXETP00000048942	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
cav3.1	LOC733765	ENSXETP00000046948	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449

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