(116 nodes) Regulation of cysteine-type endopeptidase activity involved in apoptotic process network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXETP00000014867	FIIND domain-containing protein. (1096 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	card9	Polymerase (RNA) III (DNA directed) polypeptide G (32kD). (522 aa)
	cyct	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	ENSXETP00000051440	Uncharacterized protein. (168 aa)
	laptm5	RWD domain containing 4. (265 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	sirt1	Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
	nkx3-1	Homeobox domain-containing protein. (211 aa)
	dele1	Uncharacterized protein. (563 aa)
	TNFSF15	TNF superfamily member 15. (236 aa)
	F3	Coagulation factor III, tissue factor. (282 aa)
	xiap	E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling. Belongs to the IAP family. (492 aa)
	ENSXETP00000000456	Uncharacterized protein. (198 aa)
	tnf	Thyrotropin-releasing hormone receptor 3. (227 aa)
	rffl	Dynactin subunit 2. (329 aa)
	hip1r	Uncharacterized protein. (1066 aa)
	cycs	Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	MALT1	MALT1 paracaspase. (799 aa)
	atp2a3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
	cradd.2	Colony stimulating factor 2 receptor beta common subunit. (197 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (523 aa)
	casp10	Casp10 protein; Belongs to the peptidase C14A family. (519 aa)
	tfap4	RNA binding motif protein 28. (333 aa)
	casp8	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
	pih1d1	Uncharacterized protein. (297 aa)
	ptgs2	EGF-like domain-containing protein. (619 aa)
	arl6ip5	PRA1 family protein. (188 aa)
	PDCD2	Programmed cell death 2. (369 aa)
	bcl2l11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	bcl10	Solute carrier family 35 (GDP-fucose transporter), member C2. (236 aa)
	GRAMD4	GRAM domain containing 4. (592 aa)
	ccn1	Histone deacetylase 2. (376 aa)
	bax	BCL2-associated X protein. (221 aa)
	LOC100493091	Dual specificity phosphatase 14. (231 aa)
	mmp9.1	Uncharacterized protein. (692 aa)
	fas	Vitamin D receptor. (320 aa)
	nr4a1	Nuclear receptor subfamily 4, group A, member 1. (577 aa)
	ENSXETP00000011099	Uncharacterized protein. (197 aa)
	htra2	Zic family member 4. (230 aa)
	pdcd5	Uncharacterized protein. (125 aa)
	uaca	Cell division cycle 14B. (1389 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	CASP8AP2	Uncharacterized protein. (1824 aa)
	st18	CECR2, histone acetyl-lysine reader. (1007 aa)
	slc44a1	Solute carrier family 44 (choline transporter), member 1. (326 aa)
	LOC101731336	Fibronectin type III and SPRY domain containing 1-like. (300 aa)
	rnf34	Prolactin receptor. (367 aa)
	selenof-2	Selenoprotein F. (1185 aa)
	ENSXETP00000014912	Uncharacterized protein. (385 aa)
	CAAP1	Caspase activity and apoptosis inhibitor 1. (297 aa)
	LOC100494201	Chromosome 1 open reading frame 159. (290 aa)
	tpm3	Tropomyosin 3. (197 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (463 aa)
	diablo	Diablo homolog, mitochondrial; Promotes apoptosis. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). (244 aa)
	pak2	Non-specific serine/threonine protein kinase. (518 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	dtnb-2	Dystrobrevin beta. (329 aa)
	mul1a	Potassium channel, voltage gated subfamily A regulatory beta subunit 1. (352 aa)
	ift57	Intraflagellar transport protein 57 homolog; Required for the formation of cilia. May also have pro- apoptotic function (By similarity); Belongs to the IFT57 family. (411 aa)
	prdx3	Thioredoxin domain-containing protein. (234 aa)
	pycard	Family with sequence similarity 84 member B. (199 aa)
	LOC100487218	Tripartite motif-containing protein 7-like. (478 aa)
	ccn1l	Uncharacterized protein. (238 aa)
	LOC100493406	Mediator complex subunit 15. (751 aa)
	casp2	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family. (421 aa)
	pcdhgb5l.5	Putative ortholog of protocadherin gamma B5, 5 of 5. (791 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (410 aa)
	birc5l	Baculoviral IAP repeat-containing protein 5.2; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Does not appear to exhibit anti-apoptotic activity. Plays a role in increasing blood vessel size during development (By similarity). (157 aa)
	cradd.1	CASP2 and RIPK1 domain containing adaptor with death domain. (197 aa)
	fnip1	cAMP-responsive element modulator. (1163 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (P19, inhibits CDK4). (161 aa)
	nradd	High mobility group box 3. (390 aa)
	aifm1	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (648 aa)
	rps3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (246 aa)
	lamtor5	Ragulator complex protein LAMTOR5; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (91 aa)
	acvr1c	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
	skp1-2	S-phase kinase-associated protein 1. (769 aa)
	PRR7	Proline rich 7, synaptic. (260 aa)
	birc7	Baculoviral IAP repeat-containing protein 7; Weak apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Weak inhibitor of caspase activity. (385 aa)
	LOC101732421	Baculoviral IAP repeat-containing protein 5.1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity (By similarity). (139 aa)
	THBS1	Thrombospondin 1. (1188 aa)
	bcl2l12	ArfGAP with FG repeats 1. (535 aa)
	dap	CWC22 homolog, spliceosome-associated protein. (106 aa)
	cryab	Mitochondrial ribosomal protein L23; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	FASLG	Fas ligand. (252 aa)
	bad	SMC5-SMC6 complex localization factor 1. (151 aa)
	prdx5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (200 aa)
	avp	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (161 aa)
	HIP1	Huntingtin interacting protein 1. (737 aa)
	birc2	CREB3 regulatory factor. (639 aa)
	eif2ak3	Carnitine palmitoyltransferase 1A (liver) like. (929 aa)
	tnfaip8	Tumor necrosis factor alpha-induced protein 8; Acts as a negative mediator of apoptosis; Belongs to the TNFAIP8 family. (199 aa)
	syk	Tyrosine-protein kinase. (611 aa)
	fabp1	DEAH-box helicase 9. (153 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (171 aa)
	gas6	Homeobox protein CDX-1. (672 aa)
	PIDD1	P53-induced death domain protein 1. (908 aa)
	LOC108645626	Ran-binding protein 9. (1201 aa)
	LOC733866	ATP citrate lyase. (390 aa)
	ENSXETP00000043337	Uncharacterized protein. (185 aa)
	pcasp3	Uncharacterized protein. (632 aa)
	rack1	Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1. (317 aa)
	ints1	Exosome component 5. (2211 aa)
	slc26a2-2	Solute carrier family 26 member 2. (156 aa)
	mgmt	Uncharacterized protein. (256 aa)
	REST	RE1 silencing transcription factor. (1442 aa)
	bok	Plexin A1. (214 aa)
	gper1	Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	dhcr24	FAD-binding PCMH-type domain-containing protein. (518 aa)
	ENSXETP00000043412	NACHT domain-containing protein. (1323 aa)
	TP63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (662 aa)
	naip	Asparaginase like 1. (1412 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	nle1	WD_REPEATS_REGION domain-containing protein. (486 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ENSXETP00000051440	ENSXETP00000049692	ENSXETP00000051440	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.567
APAF1	FASLG	ENSXETP00000049692	ENSXETP00000035772	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas ligand.	0.606
APAF1	aifm1	ENSXETP00000049692	ENSXETP00000032430	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.543
APAF1	bax	ENSXETP00000049692	ENSXETP00000009494	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2-associated X protein.	0.752
APAF1	bcl2l11	ENSXETP00000049692	ENSXETP00000007895	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.646
APAF1	bok	ENSXETP00000049692	ENSXETP00000044504	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Plexin A1.	0.528
APAF1	casp10	ENSXETP00000049692	ENSXETP00000006082	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Casp10 protein; Belongs to the peptidase C14A family.	0.692
APAF1	casp2	ENSXETP00000049692	ENSXETP00000024754	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family.	0.748
APAF1	casp8	ENSXETP00000049692	ENSXETP00000006109	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.818
APAF1	cflar	ENSXETP00000049692	ENSXETP00000006052	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.574
APAF1	cycs	ENSXETP00000049692	ENSXETP00000002695	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.995
APAF1	cyct	ENSXETP00000049692	ENSXETP00000051640	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.995
APAF1	diablo	ENSXETP00000049692	ENSXETP00000017507	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo homolog, mitochondrial; Promotes apoptosis. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity).	0.707
APAF1	htra2	ENSXETP00000049692	ENSXETP00000011657	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Zic family member 4.	0.497
APAF1	naip	ENSXETP00000049692	ENSXETP00000043355	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Asparaginase like 1.	0.532
APAF1	rack1	ENSXETP00000049692	ENSXETP00000045946	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1.	0.468
APAF1	uaca	ENSXETP00000049692	ENSXETP00000012118	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cell division cycle 14B.	0.417
APAF1	xiap	ENSXETP00000049692	ENSXETP00000046475	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling. Belongs to the IAP family.	0.689
CASP8AP2	casp10	ENSXETP00000013124	ENSXETP00000006082	Uncharacterized protein.	Casp10 protein; Belongs to the peptidase C14A family.	0.466
CASP8AP2	casp8	ENSXETP00000013124	ENSXETP00000006109	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.466

page 1 of 14

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About