STRINGSTRING
dact1 dact1 fktn fktn ptpn2 ptpn2 wnk2 wnk2 emilin1 emilin1 bmp2 bmp2 dusp9 dusp9 ENSXETP00000002619 ENSXETP00000002619 c1qtnf9b c1qtnf9b pik3cb pik3cb LOC101731113 LOC101731113 adipoq adipoq prdm15 prdm15 spry2 spry2 pbk pbk brsk2 brsk2 efna1 efna1 zmynd11 zmynd11 sh2b3 sh2b3 spry1 spry1 DAB2 DAB2 aida aida p2rx7 p2rx7 LOC100490828 LOC100490828 pin1 pin1 LOC100485014 LOC100485014 dusp26 dusp26 itgb1bp1 itgb1bp1 sf1 sf1 LOC733765 LOC733765 bmp4 bmp4 ptpn6 ptpn6 eif4b-2 eif4b-2 spred3 spred3 sfrp2 sfrp2 sh3rf2 sh3rf2 NF1 NF1 rnf149 rnf149 psmd10 psmd10 marveld3 marveld3 dusp16 dusp16 dusp5 dusp5 SPRY4 SPRY4 dusp3 dusp3 gtf2e2-2 gtf2e2-2 ebna1bp2-4 ebna1bp2-4 nf2 nf2 flcn flcn LOC100489307 LOC100489307 abca4-3 abca4-3 ptprr ptprr ATF3 ATF3 hipk3 hipk3 spred2 spred2 tnip1 tnip1 ezr ezr sult2b1-2 sult2b1-2 smad4.1 smad4.1 errfi1 errfi1 dusp10.2 dusp10.2 SMPD1 SMPD1 sorl1 sorl1 dusp4 dusp4 paqr3 paqr3 dusp7 dusp7 agt agt ptpn1 ptpn1 synj2bp synj2bp dusp10 dusp10 HMGCR HMGCR LOC100496423 LOC100496423 cav3.2 cav3.2 lyn lyn vrk3 vrk3 pebp4 pebp4 dag1 dag1 tmem130 tmem130 inpp5k inpp5k spry3 spry3 dusp1 dusp1 QARS1 QARS1 klhl31 klhl31 dusp6 dusp6 timp3 timp3 gper1 gper1 foxm1 foxm1 dusp19 dusp19 itch itch cav3.1 cav3.1 cav1 cav1 cyld cyld phb phb cdk5rap3 cdk5rap3 dusp13 dusp13 LOC105947969 LOC105947969 dupd1 dupd1 cyb5b-2 cyb5b-2 spred1 spred1 myc myc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dact1Dapper 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and regulates the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. May also bind to and directly stimulate the activity of tcf7l1 (By similarity); Belongs to the dapper family. (875 aa)
fktnUncharacterized protein. (495 aa)
ptpn2Proteasome 26S subunit, non-ATPase 8. (498 aa)
wnk2Guanine nucleotide binding protein (G protein), alpha 13. (1752 aa)
emilin1Uncharacterized protein. (1057 aa)
bmp2Armadillo like helical domain containing 3. (398 aa)
dusp9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
ENSXETP00000002619Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (118 aa)
c1qtnf9bHECT domain containing E3 ubiquitin protein ligase 3. (244 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
LOC101731113MDS1 and EVI1 complex locus. (443 aa)
adipoqCollagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive). (235 aa)
prdm15Stress induced phosphoprotein 1. (1202 aa)
spry2Sprouty homolog 2. (314 aa)
pbkPDZ binding kinase. (325 aa)
brsk2Uncharacterized protein. (112 aa)
efna1Ephrin RBD domain-containing protein; Belongs to the ephrin family. (146 aa)
zmynd11Zmynd11 protein. (622 aa)
sh2b3Uncharacterized protein. (617 aa)
spry1Mitochondrial amidoxime reducing component 1. (342 aa)
DAB2DAB adaptor protein 2. (820 aa)
aidaChloride intracellular channel 4. (309 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (558 aa)
LOC100490828P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (559 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (159 aa)
LOC100485014FERM domain-containing protein. (507 aa)
dusp26Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (190 aa)
itgb1bp1Ficolin 1. (209 aa)
sf1Uncharacterized protein. (674 aa)
LOC733765Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
bmp4Zinc finger, HIT-type-containing 6. (469 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
eif4b-2Eukaryotic translation initiation factor 4B. (891 aa)
spred3Glycerol-3-phosphate acyltransferase 3. (424 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
sh3rf2Caspase 3, gene 2. (731 aa)
NF1Neurofibromin 1. (2812 aa)
rnf149RING-type domain-containing protein. (398 aa)
psmd10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (227 aa)
marveld3Mannan-binding lectin serine peptidase 2. (453 aa)
dusp16Polyribonucleotide nucleotidyltransferase 1. (647 aa)
dusp5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (375 aa)
SPRY4Sprouty RTK signaling antagonist 4. (297 aa)
dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
gtf2e2-2Uncharacterized protein. (196 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
nf2FERM domain-containing protein. (635 aa)
flcnFolliculin; Belongs to the folliculin family. (579 aa)
LOC100489307Dynein, axonemal, heavy chain 2; Belongs to the peptidase C19 family. (757 aa)
abca4-3ATP binding cassette subfamily A member 4. (174 aa)
ptprrTyrosine-protein phosphatase domain-containing protein. (643 aa)
ATF3Activating transcription factor 3. (181 aa)
hipk3Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (1215 aa)
spred2Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. (413 aa)
tnip1Nef-associated factor 1. (637 aa)
ezrFERM domain-containing protein. (621 aa)
sult2b1-2Sec1 family domain containing 2. (113 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
errfi1CD53 molecule. (404 aa)
dusp10.2Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (511 aa)
sorl1Tubulin tyrosine ligase like 4. (2146 aa)
dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa)
paqr3Progestin and adipoQ receptor family member III. (311 aa)
dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
agtSERPIN domain-containing protein; Belongs to the serpin family. (459 aa)
ptpn1Tyrosine-protein phosphatase non-receptor type. (449 aa)
synj2bpSynj2bp protein. (145 aa)
dusp10NPC1 like 1. (464 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
LOC100496423Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
lynTyrosine-protein kinase. (524 aa)
vrk3Methyltransferase like 13. (511 aa)
pebp4Multiple tissue opsin. (202 aa)
dag1Peptidase S72 domain-containing protein. (885 aa)
tmem130Basic leucine zipper nuclear factor 1. (424 aa)
inpp5kIPPc domain-containing protein. (547 aa)
spry3DnaJ homolog subfamily C member 25. (289 aa)
dusp1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
QARS1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (772 aa)
klhl31Solute carrier family 25 member 10. (634 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (378 aa)
timp3Chaperonin containing TCP1 subunit 8. (214 aa)
gper1Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
foxm1AT-hook DNA binding motif containing 1. (754 aa)
dusp19Dual specificity phosphatase 19. (215 aa)
itchE3 ubiquitin-protein ligase. (853 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
cyldTLR4 interactor with leucine-rich repeats; Belongs to the peptidase C19 family. (975 aa)
phbProhibitin. (272 aa)
cdk5rap3Uncharacterized protein. (505 aa)
dusp13Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (224 aa)
LOC105947969Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
dupd1Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. (238 aa)
cyb5b-2Cytochrome b5 type B (outer mitochondrial membrane); Belongs to the Toll-like receptor family. (1024 aa)
spred1Sprouty-related, EVH1 domain-containing protein 1; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. (406 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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