STRINGSTRING
hk2 hk2 has2 has2 b3gnt3.2 b3gnt3.2 ENSXETP00000000324 ENSXETP00000000324 epm2a epm2a gbe1 gbe1 top3a-2 top3a-2 pfkfb4 pfkfb4 GSK3B GSK3B HK2 HK2 ENSXETP00000004514 ENSXETP00000004514 adamts2 adamts2 gnptab gnptab pla2g4a pla2g4a HAS3 HAS3 PHKB PHKB ugp2 ugp2 fggy fggy ppp1cb ppp1cb coq3 coq3 PGD PGD mogat2.1 mogat2.1 NAGK NAGK ACADM ACADM shpk shpk rb1cc1 rb1cc1 mecp2 mecp2 ENSXETP00000013981 ENSXETP00000013981 MIOX MIOX ric1-2 ric1-2 XYLB XYLB tf tf PYGM PYGM b3gnt3.1 b3gnt3.1 phkg1 phkg1 mogat1 mogat1 gne gne ocrl ocrl cnot3-3 cnot3-3 synj2 synj2 GUSB GUSB B3GNT4 B3GNT4 tpi1 tpi1 rpe rpe PPIP5K1 PPIP5K1 GK5 GK5 gsk3a gsk3a ndst2 ndst2 PPP1R3D PPP1R3D KHK KHK dgat2 dgat2 TREH TREH pck1 pck1 B3GNT8 B3GNT8 ENSXETP00000021565 ENSXETP00000021565 gyg1 gyg1 ippk ippk LOC101734469 LOC101734469 gys1 gys1 nr1d1 nr1d1 synj1 synj1 fcsk fcsk LOC100144987 LOC100144987 coq2 coq2 slc37a4 slc37a4 maco1-2 maco1-2 ENSXETP00000025702 ENSXETP00000025702 gk gk hk1 hk1 ENSXETP00000027068 ENSXETP00000027068 got1 got1 galk1 galk1 has1l has1l idh1 idh1 stbd1 stbd1 ndst1 ndst1 Aoah Aoah clpx-2 clpx-2 pygm pygm ndst3 ndst3 NDST4 NDST4 isyna1 isyna1 BRAF BRAF nlk.2-2 nlk.2-2 b3gnt7 b3gnt7 phkg2 phkg2 gpd2 gpd2 AGL AGL gyg2 gyg2 inpp5j inpp5j pfkp pfkp LOC101733741 LOC101733741 ENSXETP00000034578 ENSXETP00000034578 ENSXETP00000034825 ENSXETP00000034825 TKFC TKFC Ppp1r3g Ppp1r3g phka1 phka1 PFKFB1 PFKFB1 PPP1R3E PPP1R3E ppp1r3b ppp1r3b pfkfb2 pfkfb2 impa2 impa2 hs2st1 hs2st1 ext2 ext2 psmg1 psmg1 pck2 pck2 LOC100145011 LOC100145011 ppp1cc ppp1cc csgalnact1 csgalnact1 POMK POMK abhd10 abhd10 IL6ST IL6ST PYGL PYGL lrpprc lrpprc b4galt6 b4galt6 sord sord impad1 impad1 inpp5a.1 inpp5a.1 LOC100492955 LOC100492955 ppp1r3c.2 ppp1r3c.2 angptl3 angptl3 inpp5k inpp5k inpp5a.2 inpp5a.2 PPIP5K2 PPIP5K2 bpnt1 bpnt1 ppp2r2d ppp2r2d enosf1 enosf1 itpk1 itpk1 rdh5-2 rdh5-2 aldh2-2 aldh2-2 idh2 idh2 b3gnt2 b3gnt2 phka2 phka2 idnk idnk PPP1R3C PPP1R3C lepr lepr gemin5 gemin5 ENSXETP00000048395 ENSXETP00000048395 ppp1r3a ppp1r3a PCDH12 PCDH12 fbp2 fbp2 fbp1 fbp1 itpka itpka gck gck B3GNT9 B3GNT9 pnoc-2 pnoc-2 inpp5e inpp5e pfkm pfkm ppp1r1a ppp1r1a pfkfb3 pfkfb3 ganc ganc spag1 spag1 galk2 galk2 impa1 impa1 INPP5B INPP5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hk2Mannosyl-oligosaccharide glucosidase. (937 aa)
has2Has2 protein. (552 aa)
b3gnt3.2Hexosyltransferase. (395 aa)
ENSXETP00000000324Hexosyltransferase. (376 aa)
epm2aPeptidylprolyl isomerase B. (313 aa)
gbe1THO complex subunit 4. (690 aa)
top3a-2DNA topoisomerase III alpha. (278 aa)
pfkfb46PF2K domain-containing protein. (499 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
HK2Hexokinase 2. (937 aa)
ENSXETP00000004514IPPc domain-containing protein. (375 aa)
adamts2ADAM metallopeptidase with thrombospondin type 1 motif 2. (449 aa)
gnptabUncharacterized protein. (1205 aa)
pla2g4aCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (771 aa)
HAS3Hyaluronan synthase 3. (545 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1090 aa)
ugp2UTP--glucose-1-phosphate uridylyltransferase. (508 aa)
fggyUncharacterized protein. (562 aa)
ppp1cbSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity). (327 aa)
coq3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (346 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Belongs to the 6-phosphogluconate dehydrogenase family. (552 aa)
mogat2.12-acylglycerol O-acyltransferase 2; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA; Belongs to the diacylglycerol acyltransferase family. (335 aa)
NAGKN-acetylglucosamine kinase. (380 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (481 aa)
shpkFGGY_N domain-containing protein. (429 aa)
rb1cc145 kDa calcium-binding protein. (1576 aa)
mecp2Kruppel-like factor 17. (466 aa)
ENSXETP00000013981IPPc domain-containing protein. (387 aa)
MIOXMyo-inositol oxygenase. (270 aa)
ric1-2RIC1 homolog, RAB6A GEF complex partner 1. (378 aa)
XYLBXylulokinase. (562 aa)
tfSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (739 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (865 aa)
b3gnt3.1Hexosyltransferase. (429 aa)
phkg1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (413 aa)
mogat12-acylglycerol O-acyltransferase 1; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA; Belongs to the diacylglycerol acyltransferase family. (337 aa)
gneEpimerase_2 domain-containing protein. (764 aa)
ocrlHairy and enhancer of split 5, gene 2. (909 aa)
cnot3-3CCR4-NOT transcription complex subunit 3. (378 aa)
synj2Scavenger receptor class B member 1. (1551 aa)
GUSBGlucuronidase beta. (645 aa)
B3GNT4Hexosyltransferase. (363 aa)
tpi1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (268 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1361 aa)
GK5Glycerol kinase 5; Belongs to the FGGY kinase family. (562 aa)
gsk3aCACN subunit beta associated regulatory protein; Belongs to the protein kinase superfamily. (439 aa)
ndst2G protein-coupled receptor 153. (879 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (300 aa)
KHKKetohexokinase. (238 aa)
dgat2Diacylglycerol O-acyltransferase 2; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity). (358 aa)
TREHTrehalase. (582 aa)
pck1Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6. (622 aa)
B3GNT8Hexosyltransferase. (415 aa)
ENSXETP00000021565IPPc domain-containing protein. (361 aa)
gyg1Uncharacterized protein. (365 aa)
ippkInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (489 aa)
LOC101734469Uncharacterized protein. (597 aa)
gys1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (729 aa)
nr1d1Heparan sulfate 6-O-sulfotransferase 3. (529 aa)
synj1Stathmin 3. (1548 aa)
fcskPotassium channel, sodium activated subfamily T, member 2 like. (1127 aa)
LOC100144987Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (390 aa)
coq24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (387 aa)
slc37a4MFS domain-containing protein. (505 aa)
maco1-2Macoilin 1. (378 aa)
ENSXETP00000025702IPPc domain-containing protein. (358 aa)
gkExtended synaptotagmin-like protein 1; Belongs to the FGGY kinase family. (562 aa)
hk1Uncharacterized protein. (920 aa)
ENSXETP00000027068Uncharacterized protein. (614 aa)
got1Aspartate aminotransferase. (485 aa)
galk1Leucine-rich repeat transmembrane protein FLRT3. (391 aa)
has1lHyaluronan synthase 1. (566 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (482 aa)
stbd1CBM20 domain-containing protein. (418 aa)
ndst1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity); Belongs to the sulfotransferase 1 family. NDST subfamily. (878 aa)
AoahUncharacterized protein. (190 aa)
clpx-2Caseinolytic mitochondrial matrix peptidase chaperone subunit. (525 aa)
pygmAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (870 aa)
ndst3Solute carrier family 2 member 5. (873 aa)
NDST4Uncharacterized protein. (873 aa)
isyna1AT-rich interaction domain 1B. (571 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
nlk.2-2Serine/threonine-protein kinase NLK2. (513 aa)
b3gnt7Hexosyltransferase. (399 aa)
phkg2Exportin 5; Belongs to the protein kinase superfamily. (406 aa)
gpd2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (729 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1532 aa)
gyg2Hypothetical LOC496877. (395 aa)
inpp5jCalcium channel, voltage-dependent, T type, alpha 1I subunit. (767 aa)
pfkpATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (805 aa)
LOC101733741Egg envelope component ZPAX. (156 aa)
ENSXETP00000034578Hexosyltransferase. (362 aa)
ENSXETP00000034825Uncharacterized protein. (666 aa)
TKFCTriokinase and FMN cyclase. (581 aa)
Ppp1r3gCBM21 domain-containing protein. (256 aa)
phka1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1228 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (497 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (296 aa)
ppp1r3bProtein phosphatase 1 regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown (By similarity). (312 aa)
pfkfb2Phosphoinositide-3-kinase regulatory subunit 2. (536 aa)
impa2Inositol-1-monophosphatase. (309 aa)
hs2st1LOC100145562 protein. (356 aa)
ext2Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (723 aa)
psmg1Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2; Belongs to the PSMG1 family. (295 aa)
pck2Phosphoenolpyruvate carboxykinase 1, cytosolic. (604 aa)
LOC100145011Bromodomain containing 4. (588 aa)
ppp1ccSerine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity); Belongs to the PPP phosphatase family. PP-1 subfamily. (329 aa)
csgalnact1Hexosyltransferase. (531 aa)
POMKProtein O-mannose kinase. (352 aa)
abhd10Hydrolase_4 domain-containing protein. (290 aa)
IL6STInterleukin 6 signal transducer. (948 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (864 aa)
lrpprcLeucine-rich PPR motif-containing protein, mitochondrial; May play a role in RNA metabolism in both nuclei and mitochondria. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. May be involved in transcription regulation. Binds single-stranded DNA (By similarity). (1391 aa)
b4galt6Arachidonate 15-lipoxygenase, type B. (393 aa)
sordGATA binding protein 1. (361 aa)
impad1Inositol monophosphatase 3; Belongs to the inositol monophosphatase superfamily. (356 aa)
inpp5a.1Inositol polyphosphate-5-phosphatase, 40kDa. (432 aa)
LOC100492955Phosphotransferase. (600 aa)
ppp1r3c.2Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown (By similarity). (252 aa)
angptl3Carboxylesterase 3, gene 1. (456 aa)
inpp5kIPPc domain-containing protein. (547 aa)
inpp5a.2Family with sequence similarity 204 member A. (410 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1257 aa)
bpnt1Protein tyrosine phosphatase receptor type F. (329 aa)
ppp2r2dSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors. PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restri [...] (452 aa)
enosf1MR_MLE domain-containing protein. (445 aa)
itpk1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (396 aa)
rdh5-2Retinol dehydrogenase 5. (1719 aa)
aldh2-2Uncharacterized protein; Belongs to the glycosyl hydrolase 31 family. (431 aa)
idh2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (483 aa)
b3gnt2Hexosyltransferase. (397 aa)
phka2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
idnkProbable gluconokinase; Belongs to the gluconokinase GntK/GntV family. (190 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (349 aa)
leprLeucine-rich repeat-containing protein 42. (1138 aa)
gemin5Gem nuclear organelle associated protein 5; Belongs to the FBPase class 1 family. (328 aa)
ENSXETP00000048395Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (193 aa)
ppp1r3aNeuroblastoma suppressor of tumorigenicity 1. (1107 aa)
PCDH12Protocadherin 12. (1196 aa)
fbp2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (399 aa)
fbp1Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family. (338 aa)
itpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (470 aa)
gckPhosphotransferase. (458 aa)
B3GNT9Hexosyltransferase. (411 aa)
pnoc-2Prepronociceptin. (396 aa)
inpp5eMajor histocompatibility complex class I antigen. (607 aa)
pfkmUncharacterized protein. (815 aa)
ppp1r1aProtein phosphatase 1, regulatory (Inhibitor) subunit 1A. (184 aa)
pfkfb36PF2K domain-containing protein. (510 aa)
gancEukaryotic translation initiation factor 4E family member 1B; Belongs to the glycosyl hydrolase 31 family. (918 aa)
spag1Sperm associated antigen 1. (585 aa)
galk2Uncharacterized protein. (465 aa)
impa1Inositol-1-monophosphatase. (280 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (891 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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