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| | smg9 | Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between smg1 and smg8 (By similarity); Belongs to the SMG9 family. (508 aa) |
| | tmem150b | Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy- independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity). Belongs to the DRAM/TMEM150 family. (258 aa) |
| | POP1 | POP1 homolog, ribonuclease P/MRP subunit. (1037 aa) |
| | rida | Heat-responsive protein 12. (139 aa) |
| | thrap3 | Uncharacterized protein. (919 aa) |
| | yars1 | Tyrosine--tRNA ligase, cytoplasmic; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). (493 aa) |
| | LOC101734301 | STAM binding protein like 1. (365 aa) |
| | twf2 | WD repeat-containing protein 82; Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus; Belongs to the WD repeat SWD2 family. (594 aa) |
| | SKIV2L | Ski2 like RNA helicase. (1249 aa) |
| | kdelr2-2 | ER lumen protein-retaining receptor 2. (205 aa) |
| | samd4a | Protein Smaug homolog 1; Acts as a translational repressor; Belongs to the SMAUG family. (712 aa) |
| | ssb | Sjogren syndrome antigen B (Autoantigen La). (426 aa) |
| | dcp1a | mRNA_decap_C domain-containing protein. (456 aa) |
| | EXOSC5 | Exosome component 5. (215 aa) |
| | entpd5 | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | qtrt1 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (406 aa) |
| | cnp | Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1. (456 aa) |
| | cnot1 | CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRN [...] (2401 aa) |
| | cnot10 | Uncharacterized protein. (779 aa) |
| | NIT1 | Nitrilase 1. (300 aa) |
| | ENSXETP00000003176 | RNase_PH domain-containing protein. (228 aa) |
| | TET2 | Tet methylcytosine dioxygenase 2. (1797 aa) |
| | stac | SH3 and cysteine rich domain. (220 aa) |
| | elp3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (620 aa) |
| | smg5 | PINc domain-containing protein. (781 aa) |
| | zfp36 | Zfp36 protein. (313 aa) |
| | casc3 | Protein CASC3; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs th [...] (717 aa) |
| | lsm2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | LOC101734235 | Uroporphyrinogen_deCOase domain-containing protein. (302 aa) |
| | pde5a | Phosphodiesterase. (943 aa) |
| | dut-2 | dUTPase domain-containing protein. (212 aa) |
| | pym1 | Partner of Y14 and mago; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon- exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translatio [...] (200 aa) |
| | pan2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1210 aa) |
| | PDE7A | Phosphodiesterase. (467 aa) |
| | lsm1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (240 aa) |
| | Zc3h12a | C3H1-type domain-containing protein. (349 aa) |
| | idi1-2 | Isopentenyl-diphosphate delta isomerase 1. (290 aa) |
| | ENSXETP00000051711 | Uncharacterized protein. (252 aa) |
| | PDE4D | Phosphodiesterase. (719 aa) |
| | B4GALNT3 | Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (787 aa) |
| | nbas | GTP binding protein 4. (2373 aa) |
| | ell-2 | Nanos-type domain-containing protein; Belongs to the nanos family. (290 aa) |
| | lsm7 | Sm domain-containing protein. (103 aa) |
| | cnot9 | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] (299 aa) |
| | mettl16 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (549 aa) |
| | adal | A_deaminase domain-containing protein. (360 aa) |
| | pde8a | Phosphodiesterase. (823 aa) |
| | exosc6 | Exosome complex component MTR3; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (270 aa) |
| | ENSXETP00000005304 | Uncharacterized protein. (213 aa) |
| | nap1l1 | Nucleosome assembly protein 1-like 1; Acts as a chaperone for the linker histone to facilitate deposition of histone B4 onto linker DNA. Required for both remodeling of sperm chromatin into nucleosomes, and linker histone binding to nucleosome core dimers. Plays a role in tissue-specific gene regulation. Required for primitive hemopoiesis, acting upstream of tal1/scl (By similarity); Belongs to the nucleosome assembly protein (NAP) family. (402 aa) |
| | urod | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (372 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (828 aa) |
| | edc3 | Uncharacterized protein. (505 aa) |
| | nudt1 | Leucine rich repeat and fibronectin type III domain containing 3; Belongs to the Nudix hydrolase family. (156 aa) |
| | ttc37 | Uncharacterized protein. (1562 aa) |
| | entpd7 | Ectonucleoside triphosphate diphosphohydrolase 7; Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP (By similarity). (617 aa) |
| | kank2-2 | Deoxyribonuclease; Belongs to the DNase I family. (293 aa) |
| | fitm2 | Fat storage-inducing transmembrane protein 2; May play a role in the regulation of cell morphology and cytoskeletal organization. Plays an important role in lipid droplet accumulation (By similarity); Belongs to the FIT family. (263 aa) |
| | mrto4 | RL10P_insert domain-containing protein. (148 aa) |
| | blvra | Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. (290 aa) |
| | pde9a | Chromosome 16 open reading frame 72; Belongs to the cyclic nucleotide phosphodiesterase family. (344 aa) |
| | dis3l | DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (1061 aa) |
| | pm20d1 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration. (513 aa) |
| | nudt18 | Protein phosphatase 1 regulatory subunit 3B. (329 aa) |
| | pde4a | Phosphodiesterase. (690 aa) |
| | smpdl3a | Acid sphingomyelinase-like phosphodiesterase; Belongs to the acid sphingomyelinase family. (450 aa) |
| | ctif | CBP80/20-dependent translation initiation factor; Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) (By si [...] (588 aa) |
| | rab27a-2 | RAB27A, member RAS oncogene family. (240 aa) |
| | trir | LOC100145043 protein. (243 aa) |
| | blvrb | NAD(P)-bd_dom domain-containing protein. (207 aa) |
| | rad54l2 | Helicase ARIP4; DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner; Belongs to the SNF2/RAD54 helicase family. (1396 aa) |
| | ada | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (359 aa) |
| | ada.2 | A_deaminase domain-containing protein. (415 aa) |
| | xrn1 | Ribosomal protein L29. (1740 aa) |
| | bhmt | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). (438 aa) |
| | LOC100145000 | ELF1 homolog, elongation factor 1. (322 aa) |
| | parn | QKI, KH domain containing, RNA binding. (632 aa) |
| | dctpp1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (158 aa) |
| | exosc1 | LOC100170616 protein. (194 aa) |
| | exosc9 | ER lumen protein-retaining receptor 3. (432 aa) |
| | exosc2 | Uncharacterized protein. (293 aa) |
| | bbs4-2 | RNase_PH domain-containing protein. (221 aa) |
| | entpd2 | Mitogen-activated protein kinase 8 interacting protein 2; Belongs to the GDA1/CD39 NTPase family. (484 aa) |
| | exosc10 | Sigma non-opioid intracellular receptor 1. (891 aa) |
| | smg7 | Uncharacterized protein. (1192 aa) |
| | dffb | GPALPP motifs containing 1. (380 aa) |
| | pelo | Uncharacterized protein. (290 aa) |
| | nudt19 | Acyl-CoA synthetase short chain family member 3. (380 aa) |
| | rnaseh2a | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (303 aa) |
| | lsm4 | Sm domain-containing protein. (308 aa) |
| | atp6v0a2-2 | Reticulophagy regulator family member 2. (201 aa) |
| | dhx34 | Uncharacterized protein. (1142 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa) |
| | b4galnt4 | Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1138 aa) |
| | letm1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). (766 aa) |
| | xrn2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (960 aa) |
| | tet3 | Methylcytosine dioxygenase tet3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not requir [...] (1925 aa) |
| | stat5b-2 | Signal transducer and activator of transcription 5B. (260 aa) |
| | atcay-3 | Smg4_UPF3 domain-containing protein. (201 aa) |
| | polr2d-2 | Polymerase (RNA) II (DNA directed) polypeptide D. (142 aa) |
| | polr2g | Polymerase (RNA) II (DNA directed) polypeptide G. (172 aa) |
| | mlh1 | Mitochondrial ribosomal protein L1. (758 aa) |
| | tut4 | Thymidylate synthetase. (1562 aa) |
| | dcp2 | Nudix hydrolase domain-containing protein. (487 aa) |
| | upf2 | Outer dense fiber of sperm tails 2-like. (1265 aa) |
| | dxo | RAI1 domain-containing protein. (488 aa) |
| | DCPS | Decapping enzyme, scavenger. (322 aa) |
| | Cda | Cytidine deaminase. (118 aa) |
| | zcchc7 | Serine/threonine kinase 25. (562 aa) |
| | irf3-2 | Interferon regulatory factor 3. (223 aa) |
| | upp1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (311 aa) |
| | etf1 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. (447 aa) |
| | aldh1l2 | 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (922 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3653 aa) |
| | allc | Allantoicase; Utilization of purines as secondary nitrogen sources, when primary sources are limiting. (389 aa) |
| | rnaseh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (302 aa) |
| | MGC146443 | Leucine-rich repeat-containing 1. (204 aa) |
| | acot7 | TP53-regulated inhibitor of apoptosis 1. (361 aa) |
| | cnot11 | Von Willebrand factor C domain-containing protein 2-like, gene 2. (447 aa) |
| | tdo2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa) |
| | ADA2 | Adenosine deaminase 2. (424 aa) |
| | nudt8 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease. (223 aa) |
| | nudt5 | Nudix (Nucleoside diphosphate linked moiety x) type motif 5; Belongs to the Nudix hydrolase family. (221 aa) |
| | acmsd | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa) |
| | zfp36l2 | mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-con [...] (362 aa) |
| | haao | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (287 aa) |
| | aldh6a1 | Toll like receptor 3. (548 aa) |
| | rexo4 | RNA exonuclease 4. (414 aa) |
| | exosc8 | Uncharacterized protein. (276 aa) |
| | ttc38 | Tetratricopeptide repeat protein 38; Belongs to the TTC38 family. (479 aa) |
| | chmp2b | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (225 aa) |
| | polr3c | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. (568 aa) |
| | ampd3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa) |
| | cnot7 | CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa) |
| | apex1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (363 aa) |
| | patl1 | Signal transducer and activator of transcription 6. (733 aa) |
| | entpd3 | Progesterone receptor membrane component 1; Belongs to the GDA1/CD39 NTPase family. (510 aa) |
| | LOC734009 | Uncharacterized protein. (347 aa) |
| | SAMD4B | Sterile alpha motif domain containing 4B. (704 aa) |
| | smg8 | Protein smg8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of smg1 to the ribosome:SURF complex and to suppress smg1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity); Belongs to the SMG8 family. (915 aa) |
| | mus81 | Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (612 aa) |
| | uox | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (304 aa) |
| | dnase2b | Deoxyribonuclease II beta. (340 aa) |
| | dis3 | Uncharacterized protein; Belongs to the RNR ribonuclease family. (998 aa) |
| | rnaseh2c | Tetraspanin 14. (173 aa) |
| | ncbp1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U sn [...] (791 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1126 aa) |
| | PDE12 | Phosphodiesterase 12. (537 aa) |
| | ENSXETP00000049648 | Uncharacterized protein. (260 aa) |
| | entpd4 | Novel protein similar to cornifelin; Belongs to the GDA1/CD39 NTPase family. (621 aa) |
| | dcp1b | Chromosome X open reading frame 21. (567 aa) |
| | pde4b | Phosphodiesterase. (733 aa) |
| | rnaset2 | Uncharacterized protein; Belongs to the RNase T2 family. (228 aa) |
| | tut7 | Uncharacterized protein. (1515 aa) |
| | cnot8 | CCR4-NOT transcription complex, subunit 8. (289 aa) |
| | dicer1 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1899 aa) |
| | LOC100498039 | Protoporphyrinogen oxidase. (496 aa) |
| | dpyd | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1028 aa) |
| | LOC734042 | IU_nuc_hydro domain-containing protein. (319 aa) |
| | kmo | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (478 aa) |
| | hnmt | Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine; Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. (293 aa) |
| | ENSXETP00000047005 | Uncharacterized protein. (222 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (828 aa) |
| | RC3H1 | Ring finger and CCCH-type domains 1. (1123 aa) |
| | mgat1 | Mevalonate diphosphate decarboxylase. (447 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (364 aa) |
| | kynu | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (480 aa) |
| | PDE10A | Phosphodiesterase. (818 aa) |
| | setmar | Solute carrier family 26 (anion exchanger), member 11. (284 aa) |
| | efemp2 | Trichoplein, keratin filament binding. (142 aa) |
| | UPF3B | UPF3B regulator of nonsense mediated mRNA decay. (508 aa) |
| | pan3 | PAN2-PAN3 deadenylation complex subunit pan3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (809 aa) |
| | lsm6 | MGC147213 protein. (80 aa) |
| | endog | Endonuclease. (293 aa) |
| | dis3l2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (812 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (845 aa) |
| | dnase2 | Deoxyribonuclease II, lysosomal. (352 aa) |
| | mtpap | Unc-79 homolog, NALCN channel complex subunit. (569 aa) |
| | mlycd | LOC100145491 protein. (509 aa) |
| | ENSXETP00000041957 | Phosphodiesterase 9A; Belongs to the cyclic nucleotide phosphodiesterase family. (247 aa) |
| | cnot6l | Hepatocyte nuclear factor 4 gamma. (587 aa) |
| | nudt12 | Paired like homeobox 2B. (458 aa) |
| | NUDT15 | Nudix hydrolase 15. (224 aa) |
| | LRRC27 | Leucine rich repeat containing 27. (440 aa) |
| | ago4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (884 aa) |
| | dnase1l3 | Frizzled class receptor 4. (318 aa) |
| | nudt16 | Solute carrier family 45 member 2. (213 aa) |
| | nudt13 | Insulin like growth factor 1. (341 aa) |
| | entpd1 | NEDD4 binding protein 2-like 1; Belongs to the GDA1/CD39 NTPase family. (536 aa) |
| | pnpt1 | F-box DNA helicase 1. (789 aa) |
| | magoh | Retinol binding protein 4, like. (146 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3060 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (650 aa) |
| | ncbp2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (153 aa) |
| | tymp | Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (513 aa) |
| | ago1 | Protein tyrosine phosphatase receptor type S; Belongs to the argonaute family. (880 aa) |
| | nudt4 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 4. (180 aa) |
| | lin28a | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (195 aa) |
| | MTREX | Mtr4 exosome RNA helicase. (1035 aa) |
| | cdadc1 | Solute carrier family 35 member F1. (471 aa) |
| | rnaseh2b | Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (368 aa) |
| | sarm1 | KRR1, small subunit (SSU) processome component, homolog. (719 aa) |
| | noct | CCR4 carbon catabolite repression 4-like (S. cerevisiae). (458 aa) |
| | ENSXETP00000035998 | RNase_PH domain-containing protein. (207 aa) |
| | smg6 | Mitochondrial genome maintenance exonuclease 1. (1392 aa) |
| | zfp36l1 | Uncharacterized protein. (345 aa) |
| | nudt7 | Intersectin 1. (251 aa) |
| | patl2 | Protein PAT1 homolog 2; RNA-binding protein that acts as a translational repressor. (735 aa) |
| | cnot3 | Guanylate kinase 1. (726 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (194 aa) |
| | fgl1l | Fibrinogen C-terminal domain-containing protein. (279 aa) |
| | upp2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (316 aa) |
| | dut | WD repeat domain 13. (151 aa) |
| | helz2 | T-box 21. (1275 aa) |
| | gda | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (478 aa) |
| | LOC101731382 | Uncharacterized protein. (211 aa) |
| | ddx5 | Uncharacterized protein; Belongs to the DEAD box helicase family. (618 aa) |
| | pnrc2 | Proline-rich nuclear receptor coactivator 2; Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity); Belongs to the PNRC family. PNRC2 subfamily. (136 aa) |
| | ENSXETP00000034089 | RNase_PH domain-containing protein. (188 aa) |
| | mettl3 | Lysine (K)-specific demethylase 1B; Belongs to the MT-A70-like family. (573 aa) |
| | lin28b | CCHC-type domain-containing protein. (277 aa) |
| | LOC100497175 | Deoxyribonuclease; Belongs to the DNase I family. (298 aa) |
| | QPRT | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (302 aa) |
| | entpd8 | Forkhead box protein C2; Belongs to the GDA1/CD39 NTPase family. (478 aa) |
| | zpr1 | Uncharacterized protein. (446 aa) |
| | dmgdh | STIL, centriolar assembly protein. (874 aa) |
| | LOC548390 | LOC548390 protein. (322 aa) |
| | snd1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (912 aa) |
| | ENDOD1 | Endonuclease domain containing 1. (448 aa) |
| | rpl10-2 | Ribosomal protein L10; Belongs to the GDA1/CD39 NTPase family. (440 aa) |
| | ccdc122 | WD repeat domain 36. (208 aa) |
| | upb1 | LOC100145317 protein. (383 aa) |
| | eif4a3.1 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (415 aa) |
| | exosc7 | Arylsulfatase family member I. (291 aa) |
| | pde8b | Phosphodiesterase. (816 aa) |
| | pde4c | Phosphodiesterase. (801 aa) |
| | hepacam2 | Thyroid peroxidase. (572 aa) |
| | trex2 | Protein CWC15 homolog. (230 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (630 aa) |
| | cnot2 | Clathrin light chain A. (538 aa) |
| | FBH1 | F-box DNA helicase 1. (1034 aa) |
| | ENSXETP00000054108 | RNase_PH domain-containing protein. (199 aa) |
| | washc5 | WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. (1159 aa) |
| | hmox1 | Transglutaminase 5. (288 aa) |
| | rbl1-3 | Retinoblastoma-like 1. (235 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (469 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1383 aa) |
| | dnase1l2 | Deoxyribonuclease; Belongs to the DNase I family. (288 aa) |
| | EXOSC3 | Exosome component 3. (250 aa) |
| | afmid | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (296 aa) |
| | aldh1l1 | Cytosolic 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (951 aa) |
| | apobec2 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2. (234 aa) |
| | fhit | Bis(5'-adenosyl)-triphosphatase. (148 aa) |
| | nt5m | Potassium channel, voltage gated shaker related subfamily A, member 1. (227 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (582 aa) |
