STRINGSTRING
adgrb1 adgrb1 sema4a sema4a bub1b-2 bub1b-2 glul glul stim1 stim1 tnf tnf emilin1 emilin1 LOC101730668 LOC101730668 fgf1 fgf1 pik3cb pik3cb hspb6 hspb6 yjefn3 yjefn3 kdr kdr sars1 sars1 apela apela CD34 CD34 ddah1 ddah1 vash2 vash2 ddx43-2 ddx43-2 glul-2 glul-2 ppie ppie prok1 prok1 TGFB2 TGFB2 prok2 prok2 SEMA3E SEMA3E VEGFD VEGFD fut2 fut2 efna1 efna1 cd40 cd40 fgf2 fgf2 sema6c sema6c mecp2 mecp2 anxa3 anxa3 VEGFC VEGFC bmper bmper ENSXETP00000014126 ENSXETP00000014126 vash1 vash1 TNMD TNMD pdhx-2 pdhx-2 xbp1 xbp1 htatip2 htatip2 LOC100498257 LOC100498257 tgfbr2 tgfbr2 ecm1 ecm1 sirt6 sirt6 sfrp2 sfrp2 krit1 krit1 cyp1b1 cyp1b1 NF1 NF1 stat3.2 stat3.2 tlr3 tlr3 adgrb3 adgrb3 stat3.1 stat3.1 GATA2 GATA2 ENSXETP00000020321 ENSXETP00000020321 rgcc rgcc JMJD8 JMJD8 sulf1 sulf1 vegfa vegfa hgs hgs igf2 igf2 sp1 sp1 c3ar1 c3ar1 ccr2 ccr2 hoxa5 hoxa5 dlc dlc CCBE1 CCBE1 il10 il10 jup jup THBS2 THBS2 ITGA5 ITGA5 hspb1 hspb1 fut1 fut1 enpp2 enpp2 eng eng zhx2 zhx2 dll1 dll1 brca1 brca1 FOXO4 FOXO4 aggf1 aggf1 ENSXETP00000031289 ENSXETP00000031289 LOC100487812 LOC100487812 chrna7 chrna7 CREB3L1 CREB3L1 GTF2I GTF2I lep lep cdh5 cdh5 SERPINE1 SERPINE1 acvrl1 acvrl1 cemip2 cemip2 THBS1 THBS1 aplnr aplnr serpinf1 serpinf1 NR2E1 NR2E1 hmga2 hmga2 FASLG FASLG vegfb vegfb CXCR3 CXCR3 sash1 sash1 LOC100488346 LOC100488346 GAB1 GAB1 usp30 usp30 synj2bp synj2bp c5 c5 cldn5 cldn5 RECK RECK atg9a-2 atg9a-2 TEK TEK angptl3 angptl3 naxe naxe kdrl kdrl papolg-2 papolg-2 minar1 minar1 ctnnb1 ctnnb1 smad1 smad1 flt1 flt1 cxcl9 cxcl9 ITGB8 ITGB8 TNN TNN itgb3 itgb3 wars1 wars1 fkbpl fkbpl dcn dcn btg1 btg1 CEMIP CEMIP TIE1 TIE1 rock2 rock2 PLXND1 PLXND1 LOC100491930 LOC100491930 sirt1 sirt1 ROCK1 ROCK1 gata6 gata6 TSPAN12 TSPAN12 nfe2l2 nfe2l2 grem1 grem1 il1b il1b tbxa2r tbxa2r idi1-2 idi1-2 Zc3h12a Zc3h12a mydgf mydgf Lrg1 Lrg1 birc5 birc5 cyp1c1 cyp1c1 adgrb2 adgrb2 HYAL1 HYAL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adgrb1General transcription factor IIi; Belongs to the G-protein coupled receptor 2 family. (1529 aa)
sema4aSema domain-containing protein; Belongs to the semaphorin family. (681 aa)
bub1b-2Chloride channel accessory 2. (496 aa)
glulGlutamine synthetase. (371 aa)
stim1SAM domain-containing protein. (789 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
emilin1Uncharacterized protein. (1057 aa)
LOC101730668ABC transporter domain-containing protein. (310 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
hspb6Cysteine/histidine-rich 1; Belongs to the small heat shock protein (HSP20) family. (168 aa)
yjefn3Serine/threonine-protein kinase tousled-like 2. (256 aa)
kdrTransglutaminase 6; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
sars1SMAD specific E3 ubiquitin protein ligase 1. (559 aa)
apelaEndoplasmic reticulum-Golgi intermediate compartment protein 3. (54 aa)
CD34Uncharacterized protein. (329 aa)
ddah1LOC100145661 protein. (284 aa)
vash2Missing oocyte, meiosis regulator, homolog. (354 aa)
ddx43-2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (327 aa)
glul-2Glutamine synthetase. (373 aa)
ppiePeptidylprolyl isomerase E (cyclophilin E). (99 aa)
prok1Receptor tyrosine kinase-like orphan receptor 1. (106 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)
prok2Neurofilament heavy. (209 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (778 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (333 aa)
fut2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (342 aa)
efna1Ephrin RBD domain-containing protein; Belongs to the ephrin family. (146 aa)
cd40CD40. (279 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
sema6cG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
mecp2Kruppel-like factor 17. (466 aa)
anxa3Annexin. (331 aa)
VEGFCVascular endothelial growth factor C. (407 aa)
bmperUncharacterized protein. (741 aa)
ENSXETP00000014126Uncharacterized protein. (113 aa)
vash1Serine incorporator 5. (346 aa)
TNMDTenomodulin. (290 aa)
pdhx-2Oxysterol binding protein like 10. (49 aa)
xbp1Destrin, actin depolymerizing factor. (349 aa)
htatip2Chromobox 2. (270 aa)
LOC100498257StAR-related lipid transfer (START) domain containing 15; Belongs to the glutamine synthetase family. (397 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (728 aa)
ecm1O-phosphoseryl-tRNA(Sec) selenium transferase. (455 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
krit1Uncharacterized protein. (744 aa)
cyp1b1Uncharacterized protein; Belongs to the cytochrome P450 family. (550 aa)
NF1Neurofibromin 1. (2812 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
tlr3TIR domain-containing protein; Belongs to the Toll-like receptor family. (917 aa)
adgrb3Polypeptide N-acetylgalactosaminyltransferase 4; Belongs to the G-protein coupled receptor 2 family. (1506 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
GATA2GATA binding protein 2. (462 aa)
ENSXETP00000020321S-adenosylmethionine sensor upstream of mTORC1. (158 aa)
rgccDual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa)
JMJD8Jumonji domain containing 8. (268 aa)
sulf1Uncharacterized protein. (1145 aa)
vegfaGID complex subunit 8; Belongs to the PDGF/VEGF growth factor family. (311 aa)
hgsImmunoglobulin heavy chain precursor. (792 aa)
igf2IlGF domain-containing protein. (217 aa)
sp1Nuclear receptor subfamily 2 group E member 3. (747 aa)
c3ar1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ccr21-acylglycerol-3-phosphate O-acyltransferase 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
hoxa5Proteasome subunit beta 7. (274 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
CCBE1Collagen and calcium binding EGF domains 1. (394 aa)
il10Activating transcription factor 6. (172 aa)
jupUncharacterized protein. (750 aa)
THBS2Thrombospondin 2. (1215 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1022 aa)
hspb1Zinc finger MYM-type containing 4; Belongs to the small heat shock protein (HSP20) family. (211 aa)
fut1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (355 aa)
enpp2Uncharacterized protein. (922 aa)
engUncharacterized protein. (622 aa)
zhx2TBC1 domain family member 31. (1872 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
brca1Leucine rich repeat containing 18. (1655 aa)
FOXO4Forkhead box O4. (492 aa)
aggf1Uncharacterized protein. (709 aa)
ENSXETP00000031289L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (310 aa)
LOC100487812L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (342 aa)
chrna7Uncharacterized protein. (504 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (467 aa)
GTF2IGeneral transcription factor IIi. (904 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
cdh5Zinc finger RNA-binding protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (449 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (490 aa)
cemip2Inhibin subunit alpha. (1385 aa)
THBS1Thrombospondin 1. (1188 aa)
aplnrApelin receptor; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis [...] (363 aa)
serpinf1Serine (Or cysteine) proteinase inhibitor, clade F, member 1; Belongs to the serpin family. (409 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (397 aa)
hmga2Rho guanine nucleotide exchange factor 38. (150 aa)
FASLGFas ligand. (252 aa)
vegfbBradykinin receptor B2. (251 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
sash1Amyloid beta precursor protein (cytoplasmic tail) binding protein 2. (1003 aa)
LOC100488346Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1239 aa)
GAB1GRB2 associated binding protein 1. (672 aa)
usp30Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN). (519 aa)
synj2bpSynj2bp protein. (145 aa)
c5A2M_N_2 domain-containing protein. (958 aa)
cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (983 aa)
atg9a-2Autophagy related 9A. (148 aa)
TEKTEK receptor tyrosine kinase. (1114 aa)
angptl3Carboxylesterase 3, gene 1. (456 aa)
naxeNAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (291 aa)
kdrlUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1015 aa)
papolg-2Poly(A) polymerase gamma. (466 aa)
minar1UPF0258 domain-containing protein. (857 aa)
ctnnb1Dynactin subunit 5. (788 aa)
smad1Mothers against decapentaplegic homolog. (464 aa)
flt1Keratin 18, gene 2. (970 aa)
cxcl9Cyclin-dependent kinase 2 associated protein 2. (96 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (726 aa)
TNNTenascin N. (1093 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (800 aa)
wars1WHEP-TRS domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (517 aa)
fkbplSprouty-related, EVH1 domain-containing protein 1. (272 aa)
dcnDecorin; May affect the rate of fibrils formation. (364 aa)
btg1B-cell translocation gene 1, anti-proliferative. (169 aa)
CEMIPCell migration inducing hyaluronidase 1. (1377 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1131 aa)
rock2Mediator of RNA polymerase II transcription subunit 18; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1461 aa)
PLXND1Plexin D1. (1867 aa)
LOC100491930Actin, alpha 1, skeletal muscle. (1281 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1365 aa)
gata6Zinc-finger transcription factor Gata6. (524 aa)
TSPAN12Tetraspanin. (304 aa)
nfe2l2Similar to nfe2l2 (Nuclear factor (Erythroid-derived 2)-like 2). (589 aa)
grem1Gremlin. (182 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
tbxa2rLOC100145351 protein. (371 aa)
idi1-2Isopentenyl-diphosphate delta isomerase 1. (290 aa)
Zc3h12aC3H1-type domain-containing protein. (349 aa)
mydgfYES proto-oncogene 1, Src family tyrosine kinase. (158 aa)
Lrg1LRRCT domain-containing protein. (336 aa)
birc5Baculoviral IAP repeat-containing protein 5.1. (899 aa)
cyp1c1Smad nuclear interacting protein 1; Belongs to the cytochrome P450 family. (524 aa)
adgrb2HIV-1 Tat specific factor 1; Belongs to the G-protein coupled receptor 2 family. (1479 aa)
HYAL1Hyaluronidase. (753 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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