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smpd5l smpd5l ep300 ep300 cry1 cry1 c1qtnf9b c1qtnf9b adipoq adipoq c1qtnf12 c1qtnf12 ap2a1 ap2a1 clk3-2 clk3-2 ppara ppara sirt6 sirt6 stat3.2 stat3.2 stat3.1 stat3.1 tgfb1 tgfb1 SOGA1 SOGA1 midn midn cry4 cry4 cltcl1 cltcl1 plek plek ENSXETP00000034825 ENSXETP00000034825 tigar tigar smpd3 smpd3 tp53 tp53 inpp5k inpp5k cry-dash cry-dash fam3a fam3a cltc cltc PASK PASK lepr lepr erfe erfe fam3c fam3c MST1 MST1 cox11 cox11 mal2-2 mal2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smpd5lUncharacterized protein. (523 aa)
ep300Suv3 like RNA helicase. (2493 aa)
cry1Forkhead box protein F1. (616 aa)
c1qtnf9bHECT domain containing E3 ubiquitin protein ligase 3. (244 aa)
adipoqCollagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive). (235 aa)
c1qtnf12Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. (324 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
clk3-2CDC like kinase 3. (159 aa)
pparaLysosomal-associated membrane protein 1. (474 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1617 aa)
midnMidnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. (453 aa)
cry4WD repeat containing, antisense to TP73. (567 aa)
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1693 aa)
plekPleckstrin. (350 aa)
ENSXETP00000034825Uncharacterized protein. (666 aa)
tigarFructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May pla [...] (554 aa)
smpd3Barttin CLCNK-type chloride channel accessory beta subunit. (659 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
inpp5kIPPc domain-containing protein. (547 aa)
cry-dashFamily with sequence similarity 92 member B. (445 aa)
fam3aFamily with sequence similarity 3, member A. (230 aa)
cltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1692 aa)
PASKPAS domain containing serine/threonine kinase. (1189 aa)
leprLeucine-rich repeat-containing protein 42. (1138 aa)
erfeClustered mitochondria protein homolog. (311 aa)
fam3cProtein FAM3C; Involved in retinal laminar formation; Belongs to the FAM3 family. (229 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
cox11Transmembrane protein 241. (158 aa)
mal2-2V-set and transmembrane domain containing 2 like. (240 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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