(35 nodes) Positive regulation of fibroblast proliferation network (Xenopus tropicalis)

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Your Input:
	fbrs	CBFA2/RUNX1 translocation partner 3. (894 aa)
	WAPL	WAPL cohesin release factor. (1178 aa)
	lig4	DNA ligase. (911 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	fosl2	Transmembrane p24 trafficking protein 2. (316 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (856 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (312 aa)
	cdk4	Coiled-coil domain containing 151; Belongs to the protein kinase superfamily. (321 aa)
	e2f1	TEA domain family member 1 (SV40 transcriptional enhancer factor). (428 aa)
	cdca4-2	Phospholipase A(2). (142 aa)
	ddr2l	Discoidin domain receptor family, member 2. (879 aa)
	cdk6	Epidermal growth factor receptor pathway substrate 15; Belongs to the protein kinase superfamily. (333 aa)
	cd74	Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
	sirt6	Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
	pdgfb-2	Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (595 aa)
	cd248	Iroquois-class homeodomain protein irx-4. (726 aa)
	abca4-3	ATP binding cassette subfamily A member 4. (174 aa)
	ereg	NIMA-related kinase 6. (156 aa)
	jund.2	mRNA export factor. (448 aa)
	dhx9	U4/U6 small nuclear ribonucleoprotein Prp31. (1257 aa)
	ndufs4	Uncharacterized protein. (169 aa)
	brk1	Anoctamin 9. (170 aa)
	pla2g1bl	Phospholipase A(2). (150 aa)
	gas6	Homeobox protein CDX-1. (672 aa)
	fndc3b	Dermatopontin. (1205 aa)
	ctc1	Mitogen-activated protein kinase 1. (1047 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
	itgb3	Integrin beta; Belongs to the integrin beta chain family. (800 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	fn1	Fibronectin 1. (2475 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JUN	esr1	ENSXETP00000009019	ENSXETP00000047264	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.633
JUN	fosl2	ENSXETP00000009019	ENSXETP00000002365	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Transmembrane p24 trafficking protein 2.	0.885
JUN	myc	ENSXETP00000009019	ENSXETP00000053934	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.407
PDGFC	pdgfb-2	ENSXETP00000001334	ENSXETP00000019350	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	Frizzled related protein; Belongs to the PDGF/VEGF growth factor family.	0.965
abca4-3	myc	ENSXETP00000028683	ENSXETP00000053934	ATP binding cassette subfamily A member 4.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.438
cdc6	cdk4	ENSXETP00000024281	ENSXETP00000010604	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Coiled-coil domain containing 151; Belongs to the protein kinase superfamily.	0.743
cdc6	cdk6	ENSXETP00000024281	ENSXETP00000017041	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Epidermal growth factor receptor pathway substrate 15; Belongs to the protein kinase superfamily.	0.743
cdc6	e2f1	ENSXETP00000024281	ENSXETP00000012293	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	TEA domain family member 1 (SV40 transcriptional enhancer factor).	0.667
cdk4	cdc6	ENSXETP00000010604	ENSXETP00000024281	Coiled-coil domain containing 151; Belongs to the protein kinase superfamily.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.743
cdk4	e2f1	ENSXETP00000010604	ENSXETP00000012293	Coiled-coil domain containing 151; Belongs to the protein kinase superfamily.	TEA domain family member 1 (SV40 transcriptional enhancer factor).	0.433
cdk6	cdc6	ENSXETP00000017041	ENSXETP00000024281	Epidermal growth factor receptor pathway substrate 15; Belongs to the protein kinase superfamily.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.743
cdk6	e2f1	ENSXETP00000017041	ENSXETP00000012293	Epidermal growth factor receptor pathway substrate 15; Belongs to the protein kinase superfamily.	TEA domain family member 1 (SV40 transcriptional enhancer factor).	0.541
e2f1	cdc6	ENSXETP00000012293	ENSXETP00000024281	TEA domain family member 1 (SV40 transcriptional enhancer factor).	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.667
e2f1	cdk4	ENSXETP00000012293	ENSXETP00000010604	TEA domain family member 1 (SV40 transcriptional enhancer factor).	Coiled-coil domain containing 151; Belongs to the protein kinase superfamily.	0.433
e2f1	cdk6	ENSXETP00000012293	ENSXETP00000017041	TEA domain family member 1 (SV40 transcriptional enhancer factor).	Epidermal growth factor receptor pathway substrate 15; Belongs to the protein kinase superfamily.	0.541
e2f1	myc	ENSXETP00000012293	ENSXETP00000053934	TEA domain family member 1 (SV40 transcriptional enhancer factor).	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.548
esr1	JUN	ENSXETP00000047264	ENSXETP00000009019	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.633
esr1	jund.2	ENSXETP00000047264	ENSXETP00000032034	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	mRNA export factor.	0.633
esr1	myc	ENSXETP00000047264	ENSXETP00000053934	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.401
fn1	itgb3	ENSXETP00000051154	ENSXETP00000047166	Fibronectin 1.	Integrin beta; Belongs to the integrin beta chain family.	0.925

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