STRINGSTRING
ttc39c ttc39c cthrc1 cthrc1 cxcl14 cxcl14 WNT1 WNT1 dlx6 dlx6 CYTL1 CYTL1 fzd3 fzd3 otop1 otop1 FREM2 FREM2 LRIG3 LRIG3 tmub2-2 tmub2-2 RPGRIP1L RPGRIP1L ENSXETP00000008485 ENSXETP00000008485 kcnq1 kcnq1 pls1 pls1 cldn7 cldn7 otx1 otx1 LOC100490284 LOC100490284 mtmr6-2 mtmr6-2 fgf2 fgf2 s1pr2 s1pr2 bmper bmper C1QTNF5 C1QTNF5 JAG2 JAG2 irx1 irx1 lrig1 lrig1 jag1 jag1 GRXCR1 GRXCR1 foxg1 foxg1 MYO3B MYO3B grxcr2 grxcr2 MYO6 MYO6 WHRN WHRN phox2b phox2b fgf8 fgf8 cecr2 cecr2 aldh1a3 aldh1a3 tbx3 tbx3 SCRIB SCRIB IFT88 IFT88 gsdme gsdme dlx5 dlx5 pdzd7 pdzd7 dlc dlc AHI1 AHI1 TTC8 TTC8 mapkapk2 mapkapk2 otop1.2 otop1.2 gli3 gli3 sox9 sox9 adam10 adam10 sec24b sec24b cebpd cebpd CCM2 CCM2 ADGRV1 ADGRV1 dll1 dll1 mks1 mks1 KCNK2 KCNK2 slitrk6 slitrk6 hdx hdx WDPCP WDPCP sox2 sox2 tprn tprn atg5 atg5 sobp sobp hpn hpn FREM3 FREM3 ptprq ptprq ocm1 ocm1 zeb1 zeb1 wdr5 wdr5 smc2-2 smc2-2 ROR1 ROR1 ush1g ush1g impdh2 impdh2 lrrc1 lrrc1 atg4b atg4b gata3 gata3 REST REST slc4a7 slc4a7 LOC100492908 LOC100492908 slc44a4 slc44a4 tcap tcap oc90 oc90 pjvk pjvk pgghg pgghg gabra5 gabra5 SLC26A5 SLC26A5 SLC17A8 SLC17A8 gbx2.1 gbx2.1 gbx2.2 gbx2.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ttc39cDynein light chain roadblock-type 1. (570 aa)
cthrc1Diacylglycerol kinase, zeta. (235 aa)
cxcl14DEAH-box helicase 35. (102 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
dlx6Sedoheptulokinase. (260 aa)
CYTL1Cytokine like 1. (182 aa)
fzd3Developmentally regulated GTP binding protein 1; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
otop1C-reactive protein, pentraxin-related, gene 1. (608 aa)
FREM2FRAS1 related extracellular matrix 2. (3126 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1110 aa)
tmub2-2Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (661 aa)
RPGRIP1LRPGRIP1 like. (1266 aa)
ENSXETP00000008485Uncharacterized protein. (243 aa)
kcnq1KRI1 homolog; Belongs to the potassium channel family. (659 aa)
pls1OCIA domain-containing protein 1. (624 aa)
cldn7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (151 aa)
otx1Homeobox domain-containing protein. (338 aa)
LOC100490284Zinc finger protein 236. (281 aa)
mtmr6-2Myotubularin related protein 6. (673 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
s1pr2tRNA selenocysteine 1 associated protein 1. (349 aa)
bmperUncharacterized protein. (741 aa)
C1QTNF5C1q and TNF related 5. (248 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1133 aa)
irx1Iroquois-class homeodomain protein irx-1; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up- regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds [...] (467 aa)
lrig1RAR related orphan receptor C. (1043 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (290 aa)
foxg1Myb-related transcription factor, partner of profilin. (432 aa)
MYO3BMyosin IIIB. (1292 aa)
grxcr2Storkhead box 2. (234 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1278 aa)
WHRNWhirlin. (847 aa)
phox2bPolymerase (RNA) II (DNA directed) polypeptide A, 220kDa. (293 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
cecr2Leucine-rich repeat-containing protein 40. (1220 aa)
aldh1a3Protein phosphatase 1 regulatory subunit 7; Belongs to the aldehyde dehydrogenase family. (512 aa)
tbx3T-box 3. (701 aa)
SCRIBScribble planar cell polarity protein. (945 aa)
IFT88Intraflagellar transport 88. (826 aa)
gsdmeFucosyltransferase 6. (501 aa)
dlx5Nuclear factor of activated T cells 3. (298 aa)
pdzd7RAP2C, member of RAS oncogene family. (956 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
AHI1Abelson helper integration site 1. (747 aa)
TTC8Tetratricopeptide repeat domain 8. (516 aa)
mapkapk2F-box and WD repeat domain containing 5; Belongs to the protein kinase superfamily. (412 aa)
otop1.2Uncharacterized protein. (594 aa)
gli3Centrosomal protein 164kDa. (1566 aa)
sox9Transcription factor Sox-9; Transcription activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development (By similarity). May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may funct [...] (482 aa)
adam10DnaJ heat shock protein family (Hsp40) member C24. (760 aa)
sec24bCaM kinase-like vesicle-associated. (1103 aa)
cebpdCCAAT/enhancer-binding protein. (282 aa)
CCM2CCM2 scaffold protein. (450 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6137 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
mks1Heterogeneous nuclear ribonucleoprotein R. (555 aa)
KCNK2Potassium two pore domain channel subfamily K member 2. (347 aa)
slitrk6Fibromodulin. (826 aa)
hdxT-complex-associated-testis-expressed 1. (5055 aa)
WDPCPWD repeat containing planar cell polarity effector. (708 aa)
sox2Transcription factor Sox-2; Transcriptional activator. Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells responsive to FGF-neuralizing signals (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self- renewal (By similarity). (311 aa)
tprnUncharacterized protein. (996 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
sobpSine oculis binding protein homolog (Drosophila). (871 aa)
hpnPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (417 aa)
FREM3FRAS1 related extracellular matrix 3. (3133 aa)
ptprqAsparaginyl-tRNA synthetase 2, mitochondrial. (2205 aa)
ocm1Uncharacterized protein; Belongs to the parvalbumin family. (113 aa)
zeb1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (1121 aa)
wdr5WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). (334 aa)
smc2-2Structural maintenance of chromosomes 2. (1957 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (966 aa)
ush1gMediator complex subunit 6. (465 aa)
impdh2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (594 aa)
lrrc1Uncharacterized protein. (508 aa)
atg4bCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (400 aa)
gata3Uncharacterized protein. (454 aa)
RESTRE1 silencing transcription factor. (1442 aa)
slc4a7Anion exchange protein. (1232 aa)
LOC100492908Uncharacterized protein; Belongs to the potassium channel family. (687 aa)
slc44a4MAX network transcriptional repressor; Belongs to the CTL (choline transporter-like) family. (708 aa)
tcapDNA topoisomerase II alpha. (186 aa)
oc90Uncharacterized protein. (531 aa)
pjvkMitochondrial ribosomal protein L19. (359 aa)
pgghgProtein-glucosylgalactosylhydroxylysine glucosidase. (245 aa)
gabra5Ammonium transporter Rh type B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
SLC26A5Solute carrier family 26 member 5. (803 aa)
SLC17A8Solute carrier family 17 member 8. (588 aa)
gbx2.1Homeobox domain-containing protein. (340 aa)
gbx2.2Gastrulation brain homeobox 2, gene 2. (340 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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