STRINGSTRING
FANCC FANCC SMO SMO slc4a10 slc4a10 bbs2 bbs2 SLC6A4 SLC6A4 gsx2 gsx2 crppa crppa fancd2 fancd2 SHANK3 SHANK3 pafah1b1 pafah1b1 ctnna2 ctnna2 znf335 znf335 slc6a4 slc6a4 bbs1 bbs1 fgf8 fgf8 mkks mkks NF1 NF1 sos1 sos1 psen1 psen1 otx1 otx1 GDF7 GDF7 UCHL5 UCHL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FANCCFA complementation group C. (544 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
slc4a10Anion exchange protein. (1187 aa)
bbs2Bardet-Biedl syndrome 2 protein homolog. (749 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (666 aa)
gsx2Hexokinase 2. (248 aa)
crppaD-ribitol-5-phosphate cytidylyltransferase; Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows ac [...] (411 aa)
fancd2Riboflavin kinase. (1432 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1850 aa)
pafah1b1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (414 aa)
ctnna2Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system; Belongs to the vinculin/alpha-catenin family. (965 aa)
znf335Prostate transmembrane protein, androgen induced 1. (1426 aa)
slc6a4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (592 aa)
bbs1Coiled-coil domain containing 84. (591 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
mkksNeuronal calcium sensor 1. (611 aa)
NF1Neurofibromin 1. (2812 aa)
sos1Organic solute transporter subunit alpha. (1329 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
otx1Homeobox domain-containing protein. (338 aa)
GDF7Growth differentiation factor 7. (414 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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