(50 nodes) Negative regulation of peptidyl-tyrosine phosphorylation network (Xenopus tropicalis)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	parp14.2	Poly [ADP-ribose] polymerase. (1751 aa)
	sh3bp5	Proline-rich 14-like. (437 aa)
	pibf1	Uncharacterized protein. (755 aa)
	inpp5f	Spermatogenesis associated 13. (1077 aa)
	mtbp	Mdm2-binding protein; May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity). (867 aa)
	socs3l	Suppressor of cytokine signaling 3. (211 aa)
	vps25	Sialic acid binding Ig-like lectin 10. (174 aa)
	LOC100493455	RBPJ interacting and tubulin associated 1. (580 aa)
	sh2b3	Uncharacterized protein. (617 aa)
	LOC100485014	FERM domain-containing protein. (507 aa)
	CADM4	Cell adhesion molecule 4. (394 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
	zfyve28	Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity); Belongs to the lst-2 family. (954 aa)
	cbl	Uncharacterized protein. (954 aa)
	MVP	Kinesin-like protein KIF22. (739 aa)
	socs4	Fibroblast growth factor binding protein 2. (436 aa)
	LOC733765	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	ptpn6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LRRK1	Leucine rich repeat kinase 1. (2003 aa)
	LOC101732564	Poly [ADP-ribose] polymerase. (1848 aa)
	ENSXETP00000020553	Poly [ADP-ribose] polymerase. (412 aa)
	slc25a21-2	Poly [ADP-ribose] polymerase. (1541 aa)
	cblb	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (982 aa)
	LOC100485144	Poly [ADP-ribose] polymerase. (1540 aa)
	gprc5a	G_PROTEIN_RECEP_F3_4 domain-containing protein. (362 aa)
	socs3	Suppressor of cytokine signaling 3. (199 aa)
	ebna1bp2-4	EBNA1 binding protein 2. (876 aa)
	chmp6	LOC100125185 protein. (200 aa)
	nf2	FERM domain-containing protein. (635 aa)
	fam72a	Spermatogenesis associated 1. (151 aa)
	tsg101	Thrombospondin 2. (239 aa)
	dmtn	HP domain-containing protein. (416 aa)
	ptpn2	Proteasome 26S subunit, non-ATPase 8. (498 aa)
	ibtk	Laminin subunit alpha 4. (1337 aa)
	errfi1	CD53 molecule. (404 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1152 aa)
	cblc	Uncharacterized protein. (425 aa)
	sema4d	Keratin 70; Belongs to the semaphorin family. (862 aa)
	cav3.2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	socs5	Suppressor of cytokine signaling 5. (535 aa)
	samsn1	Ankyrin repeat and SOCS box containing 7. (388 aa)
	rack1	Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1. (317 aa)
	sh3bp5l	SH3 domain-binding protein 5-like; Functions as guanine nucleotide exchange factor (GEF) for rab11a. (373 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	fgfr1op	Uncharacterized protein. (451 aa)
	srcin1	AIP3 domain-containing protein. (1702 aa)
	socs1	Novel protein similar to suppressor of cytokine signaling 1. (211 aa)
	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity); Belongs to the LRWD1 family. (691 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100485014	nf2	ENSXETP00000013658	ENSXETP00000027533	FERM domain-containing protein.	FERM domain-containing protein.	0.904
LOC733765	cav1	ENSXETP00000016352	ENSXETP00000048942	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
LOC733765	cav3.1	ENSXETP00000016352	ENSXETP00000046948	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
LOC733765	cav3.2	ENSXETP00000016352	ENSXETP00000039803	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
cav1	LOC733765	ENSXETP00000048942	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
cav3.1	LOC733765	ENSXETP00000046948	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
cav3.2	LOC733765	ENSXETP00000039803	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
cbl	cblb	ENSXETP00000014969	ENSXETP00000022441	Uncharacterized protein.	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.	0.906
cbl	cblc	ENSXETP00000014969	ENSXETP00000036221	Uncharacterized protein.	Uncharacterized protein.	0.905
cblb	cbl	ENSXETP00000022441	ENSXETP00000014969	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.	Uncharacterized protein.	0.906
cblb	cblc	ENSXETP00000022441	ENSXETP00000036221	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.	Uncharacterized protein.	0.906
cblc	cbl	ENSXETP00000036221	ENSXETP00000014969	Uncharacterized protein.	Uncharacterized protein.	0.905
cblc	cblb	ENSXETP00000036221	ENSXETP00000022441	Uncharacterized protein.	E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.	0.906
chmp6	tsg101	ENSXETP00000027326	ENSXETP00000028217	LOC100125185 protein.	Thrombospondin 2.	0.760
chmp6	vps25	ENSXETP00000027326	ENSXETP00000010292	LOC100125185 protein.	Sialic acid binding Ig-like lectin 10.	0.997
mtbp	socs1	ENSXETP00000005693	ENSXETP00000053531	Mdm2-binding protein; May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).	Novel protein similar to suppressor of cytokine signaling 1.	0.548
mtbp	socs3	ENSXETP00000005693	ENSXETP00000025441	Mdm2-binding protein; May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).	Suppressor of cytokine signaling 3.	0.548
mtbp	socs4	ENSXETP00000005693	ENSXETP00000015856	Mdm2-binding protein; May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).	Fibroblast growth factor binding protein 2.	0.548
mtbp	socs5	ENSXETP00000005693	ENSXETP00000041923	Mdm2-binding protein; May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).	Suppressor of cytokine signaling 5.	0.548
nf2	LOC100485014	ENSXETP00000027533	ENSXETP00000013658	FERM domain-containing protein.	FERM domain-containing protein.	0.904

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