(58 nodes) Regulation of insulin secretion network (Xenopus tropicalis)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	rfx3	Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (783 aa)
	il1b	Interleukin-1; Belongs to the IL-1 family. (286 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
	nr1h4	Protein phosphatase 5, catalytic subunit. (458 aa)
	wnk3	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
	NDUFAF2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (161 aa)
	trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (226 aa)
	scpep1-2	Serine carboxypeptidase 1. (48 aa)
	REST	RE1 silencing transcription factor. (1442 aa)
	gper1	Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	SYTL4	Synaptotagmin like 4. (692 aa)
	PLA2G6	Phospholipase A2 group VI. (806 aa)
	efna5	Ephrin-A5; Belongs to the ephrin family. (228 aa)
	pick1-2	Uncharacterized protein. (421 aa)
	bad	SMC5-SMC6 complex localization factor 1. (151 aa)
	syt7	C2 domain-containing protein. (777 aa)
	INHBB	Inhibin subunit beta B. (131 aa)
	acvr1c	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	myrip	Selenoprotein N. (833 aa)
	adprm-2	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase. (317 aa)
	ENSXETP00000032157	Ion_trans domain-containing protein. (263 aa)
	PIM3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (323 aa)
	hmgn3	Integrin subunit alpha 2b. (124 aa)
	tmtc3-2	Transmembrane and tetratricopeptide repeat containing 3. (152 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (132 aa)
	aacs	Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. (727 aa)
	foxo1	Forkhead box protein O1; Transcription factor. (626 aa)
	ccn3	Superoxide dismutase [Cu-Zn]. (344 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (666 aa)
	stxbp4	Uncharacterized protein. (516 aa)
	klf7	Kruppel-like factor 7 (Ubiquitous). (296 aa)
	RFX6	Regulatory factor X6. (931 aa)
	arntl	Sin3A associated protein 18kDa. (513 aa)
	nr1d1	Heparan sulfate 6-O-sulfotransferase 3. (529 aa)
	Il6	Uncharacterized protein. (150 aa)
	rph3al	Uncharacterized protein. (351 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (633 aa)
	midn	Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. (453 aa)
	lrp5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa)
	fam3d	Family with sequence similarity 3, member D. (226 aa)
	sirt6	Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
	c2cd2l	Uncharacterized protein. (662 aa)
	psmd9	Ryanodine receptor 1 (skeletal). (211 aa)
	pdhx-2	Oxysterol binding protein like 10. (49 aa)
	slc8b1	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
	lrrc8a	CWC27 spliceosome-associated protein. (809 aa)
	tm7sf3	Histone-binding protein RBBP4. (505 aa)
	LOC101733206	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (226 aa)
	pdx1	Hepatocyte nuclear factor 4, beta. (271 aa)
	hadh	VPS41, HOPS complex subunit. (315 aa)
	SYT9	Synaptotagmin 9. (509 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (322 aa)
	sox1	3-phosphoinositide dependent protein kinase 1. (663 aa)
	blk	Tyrosine-protein kinase. (497 aa)
	LOC101730668	ABC transporter domain-containing protein. (310 aa)
	sri	Sorcin. (195 aa)
	tnf	Thyrotropin-releasing hormone receptor 3. (227 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
INHBB	acvr1c	ENSXETP00000034062	ENSXETP00000033421	Inhibin subunit beta B.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.962
Il6	il1b	ENSXETP00000024453	ENSXETP00000052231	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.820
Il6	lep	ENSXETP00000024453	ENSXETP00000033039	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.596
Il6	tnf	ENSXETP00000024453	ENSXETP00000001062	Uncharacterized protein.	Thyrotropin-releasing hormone receptor 3.	0.611
aacs	hadh	ENSXETP00000030308	ENSXETP00000010592	Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA.	VPS41, HOPS complex subunit.	0.953
acvr1c	INHBB	ENSXETP00000033421	ENSXETP00000034062	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin subunit beta B.	0.962
arntl	nr1d1	ENSXETP00000026572	ENSXETP00000024960	Sin3A associated protein 18kDa.	Heparan sulfate 6-O-sulfotransferase 3.	0.680
arntl	sirt6	ENSXETP00000026572	ENSXETP00000018568	Sin3A associated protein 18kDa.	Sirtuin (Silent mating type information regulation 2 homolog) 6.	0.541
hadh	aacs	ENSXETP00000010592	ENSXETP00000030308	VPS41, HOPS complex subunit.	Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA.	0.953
il1b	Il6	ENSXETP00000052231	ENSXETP00000024453	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein.	0.820
il1b	lep	ENSXETP00000052231	ENSXETP00000033039	Interleukin-1; Belongs to the IL-1 family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.522
il1b	tnf	ENSXETP00000052231	ENSXETP00000001062	Interleukin-1; Belongs to the IL-1 family.	Thyrotropin-releasing hormone receptor 3.	0.682
lep	Il6	ENSXETP00000033039	ENSXETP00000024453	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Uncharacterized protein.	0.596
lep	il1b	ENSXETP00000033039	ENSXETP00000052231	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Interleukin-1; Belongs to the IL-1 family.	0.522
lep	pdx1	ENSXETP00000033039	ENSXETP00000011031	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Hepatocyte nuclear factor 4, beta.	0.549
nr1d1	arntl	ENSXETP00000024960	ENSXETP00000026572	Heparan sulfate 6-O-sulfotransferase 3.	Sin3A associated protein 18kDa.	0.680
pdx1	lep	ENSXETP00000011031	ENSXETP00000033039	Hepatocyte nuclear factor 4, beta.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.549
sirt4	sirt6	ENSXETP00000008529	ENSXETP00000018568	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	Sirtuin (Silent mating type information regulation 2 homolog) 6.	0.744
sirt6	arntl	ENSXETP00000018568	ENSXETP00000026572	Sirtuin (Silent mating type information regulation 2 homolog) 6.	Sin3A associated protein 18kDa.	0.541
sirt6	sirt4	ENSXETP00000018568	ENSXETP00000008529	Sirtuin (Silent mating type information regulation 2 homolog) 6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.744

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