STRINGSTRING
tnf tnf ADCY1 ADCY1 shank2 shank2 rab3gap1 rab3gap1 LAMA1 LAMA1 SLC24A1 SLC24A1 grin2d grin2d stx1a stx1a NFATC4 NFATC4 sytl4 sytl4 cacng2 cacng2 SHISA7 SHISA7 GRIN2B GRIN2B zdhhc12 zdhhc12 TSHZ3 TSHZ3 sqstm1 sqstm1 lgi4 lgi4 slc1a3 slc1a3 mecp2 mecp2 fmr1 fmr1 rims2 rims2 snap25 snap25 clstn3 clstn3 serpine2 serpine2 stx3 stx3 CLSTN2 CLSTN2 chchd6 chchd6 cacnb4 cacnb4 cacng8 cacng8 cacng7 cacng7 app app CLSTN1 CLSTN1 rarb rarb crtc1 crtc1 syt12 syt12 BRAF BRAF stx2 stx2 rapsn rapsn igsf11 igsf11 stx1b stx1b rims3 rims3 fes fes slc24a2 slc24a2 NR2E1 NR2E1 ror2 ror2 lrrtm1 lrrtm1 med16 med16 SHANK3 SHANK3 rims1 rims1 GRIN2C GRIN2C gper1 gper1 lgmn lgmn glrx3 glrx3 slc4a8 slc4a8 ca7 ca7 lgi1 lgi1 tnr tnr cdk12 cdk12 ntrk2 ntrk2 prrt1 prrt1 reln reln NPS NPS eif2ak4 eif2ak4 wnk3 wnk3 lama2 lama2 dtnbp1 dtnbp1 nptn nptn GRIN2A GRIN2A NALCN NALCN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
shank2Uncharacterized protein. (1829 aa)
rab3gap1Ribosomal protein S20. (914 aa)
LAMA1Laminin subunit alpha 1. (3101 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (724 aa)
grin2dShort chain dehydrogenase/reductase family 42E, member 1. (1274 aa)
stx1aProbable RNA polymerase II nuclear localization protein SLC7A6OS; Belongs to the syntaxin family. (301 aa)
NFATC4Nuclear factor of activated T cells 4. (1091 aa)
sytl4Synaptotagmin like 4. (246 aa)
cacng2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
SHISA7Shisa family member 7. (504 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1449 aa)
zdhhc12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (276 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1049 aa)
sqstm1Uncharacterized protein. (452 aa)
lgi4LRRCT domain-containing protein. (578 aa)
slc1a3Amino acid transporter. (542 aa)
mecp2Kruppel-like factor 17. (466 aa)
fmr1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250|UniProtKB:P51113, ECO:0000250|UniProtKB:Q06787. (590 aa)
rims2Angiomotin like 1. (1760 aa)
snap25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
clstn3Glycogen synthase kinase 3 alpha. (965 aa)
serpine2SERPIN domain-containing protein; Belongs to the serpin family. (424 aa)
stx3Syntaxin 3; Belongs to the syntaxin family. (289 aa)
CLSTN2Calsyntenin 2. (921 aa)
chchd6MICOS complex subunit mic25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily. (282 aa)
cacnb4SH3 domain-containing protein. (550 aa)
cacng8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (353 aa)
cacng7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
appGeneral transcription factor IIE subunit 2. (769 aa)
CLSTN1Calsyntenin 1. (988 aa)
rarbRetinoic acid receptor beta. (52 aa)
crtc1Josephin domain containing 1. (623 aa)
syt12Cilia and flagella associated protein 100. (414 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
stx2t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (329 aa)
rapsnMgc107969 protein. (414 aa)
igsf11GTP binding protein 2. (360 aa)
stx1bt-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (332 aa)
rims3Calcium channel, voltage-dependent, gamma subunit 3. (308 aa)
fesVoltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (305 aa)
slc24a2ADNP homeobox 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (657 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (397 aa)
ror2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
lrrtm1Cerebellar degeneration-related protein 2-like. (521 aa)
med16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (829 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1850 aa)
rims1E3 ubiquitin-protein ligase rnf146. (1560 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1189 aa)
gper1Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
lgmnProtein phosphatase 1 regulatory subunit 9A. (433 aa)
glrx3Glutaredoxin-3; Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. (329 aa)
slc4a8Anion exchange protein. (1090 aa)
ca7Protein interacting with cyclin A1; Belongs to the alpha-carbonic anhydrase family. (266 aa)
lgi1Leucine-rich, glioma inactivated 1. (547 aa)
tnrGRB2 associated binding protein 1. (1355 aa)
cdk12Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating srsf1/sf2 (By similarity). (1466 aa)
ntrk2Tyrosine-protein kinase receptor. (821 aa)
prrt1Sushi domain containing 2. (240 aa)
relnG protein-coupled receptor 119. (3463 aa)
NPSNeuropeptide S. (71 aa)
eif2ak4Uncharacterized protein. (1668 aa)
wnk3Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
lama2WD repeat and coiled-coil-containing protein. (3099 aa)
dtnbp1Nuclear receptor coactivator 1. (355 aa)
nptnUncharacterized protein. (407 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1318 aa)
NALCNSodium leak channel, non-selective. (1753 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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