STRINGSTRING
il1rapl2 il1rapl2 tmprss13 tmprss13 unc13c unc13c impdh2 impdh2 ctnnb1 ctnnb1 ppfia2 ppfia2 LAMB1 LAMB1 il1rap il1rap efna5 efna5 lgi2 lgi2 dip2a dip2a adgrl2 adgrl2 SHANK3 SHANK3 cbln1 cbln1 pick1-2 pick1-2 ephb3 ephb3 lrrtm1 lrrtm1 snca snca ENSXETP00000038077 ENSXETP00000038077 PALM PALM DOK7 DOK7 fnta fnta lyl1-2 lyl1-2 wasf1 wasf1 cdc42 cdc42 SHANK1 SHANK1 spg11 spg11 fes fes snta1 snta1 nos1ap nos1ap dbn1 dbn1 p2rx2 p2rx2 Dock10 Dock10 ptprd ptprd PCLO PCLO nptn nptn TANC1 TANC1 gphn gphn gpr180-2 gpr180-2 NLGN2 NLGN2 PPFIBP2 PPFIBP2 slitrk6 slitrk6 slitrk1 slitrk1 synpo synpo NTNG2 NTNG2 nlgn3 nlgn3 cnppd1-2 cnppd1-2 NTNG1 NTNG1 rarb rarb tsc1 tsc1 rab29 rab29 wasf2 wasf2 agrn agrn CYFIP1 CYFIP1 unc13a unc13a ska1-2 ska1-2 baiap2 baiap2 app app LOC100485974 LOC100485974 adam10 adam10 flrt3 flrt3 LOC100127682 LOC100127682 cacnb4 cacnb4 wnt7b wnt7b gabra1 gabra1 pdzrn4 pdzrn4 FILIP1 FILIP1 ttyh2 ttyh2 clstn3 clstn3 cbln4 cbln4 sncg sncg efnb2 efnb2 fbxo45 fbxo45 lrrk2 lrrk2 bcl7b-2 bcl7b-2 actg1 actg1 sybu sybu GABRA2 GABRA2 psen1 psen1 BCAN BCAN pak1 pak1 gpm6a gpm6a mecp2 mecp2 lmbr1-2 lmbr1-2 LOC100486532 LOC100486532 gdnf gdnf ephb1 ephb1 nlgn4x nlgn4x LRRTM4 LRRTM4 SEMA3E SEMA3E pdzrn3 pdzrn3 drp2 drp2 homer1 homer1 dgkb-2 dgkb-2 ERC2 ERC2 wasf3 wasf3 PPFIBP1 PPFIBP1 zdhhc12 zdhhc12 cntn5 cntn5 dock10 dock10 znf180-2 znf180-2 IL1RAPL1 IL1RAPL1 mdk mdk bbox1-2 bbox1-2 SHISA7 SHISA7 cacng2 cacng2 zcchc4 zcchc4 NFATC4 NFATC4 kctd1 kctd1 LOC100488020 LOC100488020 gnpat gnpat dlg3 dlg3 LOC100488567 LOC100488567 npas4 npas4 add2 add2 musk musk ENSXETP00000003955 ENSXETP00000003955 dlg2 dlg2 sez6l2 sez6l2 cacnb3 cacnb3 dlgap3 dlgap3 sez6l sez6l pak3 pak3 dctn1 dctn1 ppfia1 ppfia1 PPFIA3 PPFIA3 SDK2 SDK2 glrb glrb actb actb shank2 shank2 lrfn4 lrfn4 prmt3 prmt3 LRRTM3 LRRTM3 hao2-2 hao2-2 cacnb1 cacnb1 NEFL NEFL PLXND1 PLXND1 ITGA3 ITGA3 reln reln sncb sncb tnc tnc prrt1 prrt1 ptprf ptprf tnr tnr REST REST farp1 farp1 nlgn1 nlgn1 lgmn lgmn SEZ6 SEZ6 ALS2 ALS2 COLQ COLQ CACNB2 CACNB2 LAMB2 LAMB2 cntn2 cntn2 erc1 erc1 nfasc nfasc LRFN5 LRFN5 dbnl dbnl cnksr2 cnksr2 itpka itpka adss adss brdt-2 brdt-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
il1rapl2Interleukin 1 receptor accessory protein-like 2. (686 aa)
tmprss13Transmembrane serine protease 13. (505 aa)
unc13cAcetyl-CoA acyltransferase 1. (2189 aa)
impdh2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (594 aa)
ctnnb1Dynactin subunit 5. (788 aa)
ppfia2INO80 complex subunit B. (1232 aa)
LAMB1Laminin subunit beta 1. (1808 aa)
il1rapUncharacterized protein. (690 aa)
efna5Ephrin-A5; Belongs to the ephrin family. (228 aa)
lgi2Sodium channel, voltage gated, type II alpha subunit. (538 aa)
dip2aFamily with sequence similarity 83 member B. (1573 aa)
adgrl2Hemopexin; Belongs to the G-protein coupled receptor 2 family. (1463 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1850 aa)
cbln1C1q domain-containing protein. (191 aa)
pick1-2Uncharacterized protein. (421 aa)
ephb3EPH receptor B3. (988 aa)
lrrtm1Cerebellar degeneration-related protein 2-like. (521 aa)
sncaAlpha-synuclein; Belongs to the synuclein family. (140 aa)
ENSXETP00000038077Zf-piccolo domain-containing protein. (529 aa)
PALMParalemmin. (369 aa)
DOK7Docking protein 7. (675 aa)
fntaZinc finger CCHC-type containing 17. (379 aa)
lyl1-2Canopy FGF signaling regulator 1. (603 aa)
wasf1Wasf1 protein. (558 aa)
cdc42Uncharacterized protein. (212 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1900 aa)
spg11Lymphocyte specific protein 1. (1876 aa)
fesVoltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (305 aa)
snta1Outer dense fiber protein 3. (499 aa)
nos1apSKI proto-oncogene. (673 aa)
dbn1ADF-H domain-containing protein. (665 aa)
p2rx2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (357 aa)
Dock10PH domain-containing protein. (498 aa)
ptprdSemaphorin 6D. (1925 aa)
PCLOPiccolo presynaptic cytomatrix protein. (3386 aa)
nptnUncharacterized protein. (407 aa)
TANC1Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (1828 aa)
gphnGlucocorticoid modulatory element binding protein 2. (970 aa)
gpr180-2G protein-coupled receptor 180. (698 aa)
NLGN2Neuroligin 2. (602 aa)
PPFIBP2PPFIA binding protein 2. (996 aa)
slitrk6Fibromodulin. (826 aa)
slitrk1LOC100124997 protein. (696 aa)
synpoTransmembrane protein 147. (949 aa)
NTNG2Netrin G2. (689 aa)
nlgn3DEAD-box helicase 17. (850 aa)
cnppd1-2Caspase 2. (84 aa)
NTNG1Netrin G1. (465 aa)
rarbRetinoic acid receptor beta. (52 aa)
tsc1Distal-less homeobox 1. (1139 aa)
rab29LOC100135159 protein. (204 aa)
wasf2Forkhead box Q1. (484 aa)
agrnSOS Ras/Rac guanine nucleotide exchange factor 1. (2105 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1272 aa)
unc13aCCCTC-binding factor. (1677 aa)
ska1-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
baiap2Uncharacterized protein. (554 aa)
appGeneral transcription factor IIE subunit 2. (769 aa)
LOC100485974Leucine-rich melanocyte differentiation-associated. (1021 aa)
adam10DnaJ heat shock protein family (Hsp40) member C24. (760 aa)
flrt3Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (By similarity). Modulates cadherin-dependent cell-cell adhesion and cell sorting (By similarity). Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing ntn1. mediates axon growt [...] (648 aa)
LOC100127682Uncharacterized protein. (520 aa)
cacnb4SH3 domain-containing protein. (550 aa)
wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (285 aa)
gabra1Netrin G2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (423 aa)
pdzrn4Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma. (774 aa)
FILIP1Filamin A interacting protein 1. (1208 aa)
ttyh2Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. Belongs to the tweety family. (534 aa)
clstn3Glycogen synthase kinase 3 alpha. (965 aa)
cbln4Bromodomain PHD finger transcription factor. (200 aa)
sncgGamma-synuclein; Belongs to the synuclein family. (130 aa)
efnb2Solute carrier family 41 member 2; Belongs to the ephrin family. (329 aa)
fbxo45F-box/SPRY domain-containing protein 1. (282 aa)
lrrk2Hes family bHLH transcription factor 2. (2514 aa)
bcl7b-2BCL7B, BAF complex component. (4211 aa)
actg1Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
sybuFAD-dependent oxidoreductase domain containing 2. (653 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (499 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
BCANBrevican. (1148 aa)
pak1Non-specific serine/threonine protein kinase. (521 aa)
gpm6aGlycoprotein M6A. (278 aa)
mecp2Kruppel-like factor 17. (466 aa)
lmbr1-2Limb region 1 protein homolog. (545 aa)
LOC100486532TGc domain-containing protein. (608 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (227 aa)
ephb1Salt inducible kinase 1. (995 aa)
nlgn4xNeuroligin 4. (813 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (622 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (778 aa)
pdzrn3FRAS1 related extracellular matrix protein 2. (1062 aa)
drp2Chromosome 2 open reading frame 73. (944 aa)
homer1Prolactin-releasing peptide receptor-like. (394 aa)
dgkb-2Uncharacterized protein. (90 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (944 aa)
wasf3WH2 domain-containing protein. (520 aa)
PPFIBP1PPFIA binding protein 1. (1014 aa)
zdhhc12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (276 aa)
cntn5Sonic hedgehog. (1124 aa)
dock10DHR-2 domain-containing protein; Belongs to the DOCK family. (433 aa)
znf180-2Zinc finger protein 180. (153 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (686 aa)
mdkMidkine; Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non- proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (By similarity). Inhibits mesoderm formation and promotes neural formation during development. Plays a role in development of the neuromuscular junction (NMJ). [...] (142 aa)
bbox1-2Cysteine-rich secretory protein 2; Belongs to the G-protein coupled receptor 2 family. (1476 aa)
SHISA7Shisa family member 7. (504 aa)
cacng2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
zcchc4rRNA N6-adenosine-methyltransferase ZCCHC4; rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. (487 aa)
NFATC4Nuclear factor of activated T cells 4. (1091 aa)
kctd1Potassium channel tetramerization domain containing 1. (302 aa)
LOC100488020PID domain-containing protein. (287 aa)
gnpatPQ loop repeat containing 2 like; Belongs to the GPAT/DAPAT family. (672 aa)
dlg3Hyaluronan-mediated motility receptor (RHAMM); Belongs to the MAGUK family. (851 aa)
LOC100488567ADAM metallopeptidase with thrombospondin type 1 motif 10. (1027 aa)
npas4Npas4 protein. (721 aa)
add2Aldolase_II domain-containing protein. (725 aa)
muskNIPA magnesium transporter 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (935 aa)
ENSXETP00000003955Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed. (662 aa)
dlg2Hemojuvelin BMP co-receptor. (913 aa)
sez6l2Uncharacterized protein. (736 aa)
cacnb3GuKc domain-containing protein. (490 aa)
dlgap3Uncharacterized protein. (999 aa)
sez6lCullin 4B. (1002 aa)
pak3Non-specific serine/threonine protein kinase. (564 aa)
dctn1CAP-Gly domain-containing protein. (1290 aa)
ppfia1Uncharacterized protein. (1265 aa)
PPFIA3PTPRF interacting protein alpha 3. (1207 aa)
SDK2Sidekick cell adhesion molecule 2. (2125 aa)
glrbGlycine receptor, beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
actbActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
shank2Uncharacterized protein. (1829 aa)
lrfn4Uncharacterized protein. (722 aa)
prmt3SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (523 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (514 aa)
hao2-2Hydroxyacid oxidase 2 (long chain). (1011 aa)
cacnb1HPS1, biogenesis of lysosomal organelles complex 3 subunit 1. (628 aa)
NEFLNeurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. (554 aa)
PLXND1Plexin D1. (1867 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1046 aa)
relnG protein-coupled receptor 119. (3463 aa)
sncbBeta-synuclein; Belongs to the synuclein family. (134 aa)
tncAdenylate cyclase activating polypeptide 1 (pituitary). (1983 aa)
prrt1Sushi domain containing 2. (240 aa)
ptprfMajor facilitator superfamily domain containing 14B. (1910 aa)
tnrGRB2 associated binding protein 1. (1355 aa)
RESTRE1 silencing transcription factor. (1442 aa)
farp1Mucin 6, oligomeric mucus/gel-forming. (1040 aa)
nlgn1Janus kinase 1 (a protein tyrosine kinase). (837 aa)
lgmnProtein phosphatase 1 regulatory subunit 9A. (433 aa)
SEZ6Seizure related 6 homolog. (1021 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1640 aa)
COLQCollagen like tail subunit of asymmetric acetylcholinesterase. (437 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (646 aa)
LAMB2Laminin subunit beta 2. (1793 aa)
cntn2Polymerase (RNA) II subunit I. (1013 aa)
erc1FIP-RBD domain-containing protein. (1097 aa)
nfascTransmembrane protein 56. (1313 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (775 aa)
dbnlAdaptor related protein complex 2 subunit sigma 1. (455 aa)
cnksr2Mitochondrial E3 ubiquitin protein ligase 1a. (1068 aa)
itpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (470 aa)
adssAdenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (477 aa)
brdt-2Bromodomain testis-specific protein. (1925 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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