STRINGSTRING
smarcal1 smarcal1 ENSXETP00000054108 ENSXETP00000054108 cyb5b-2 cyb5b-2 ppp2r3c ppp2r3c tbx21 tbx21 morn5 morn5 RC3H1 RC3H1 sash3 sash3 samsn1 samsn1 THOC1 THOC1 MSH2 MSH2 fkbp10-2 fkbp10-2 lyn lyn ATM ATM asxl3-2 asxl3-2 IKZF3 IKZF3 syk syk stat6 stat6 bad bad ENSXETP00000035998 ENSXETP00000035998 ENSXETP00000034089 ENSXETP00000034089 akirin2 akirin2 ccdc122 ccdc122 BCL2 BCL2 peli2 peli2 mmp14 mmp14 EXOSC3 EXOSC3 cd38 cd38 LOC101733556 LOC101733556 ebna1bp2-4 ebna1bp2-4 snrpb2-3 snrpb2-3 RIF1 RIF1 kdelr2-2 kdelr2-2 ENSXETP00000001570 ENSXETP00000001570 clcf1 clcf1 atad5 atad5 nup214-2 nup214-2 ENSXETP00000003176 ENSXETP00000003176 il27ra il27ra blk blk itih5-2 itih5-2 phactr1-2 phactr1-2 hsd17b2 hsd17b2 ENSXETP00000004837 ENSXETP00000004837 ENSXETP00000004850 ENSXETP00000004850 plcxd3 plcxd3 acly-2 acly-2 F7CYZ3_XENTR F7CYZ3_XENTR tyrobp tyrobp kmt5c kmt5c ptk7 ptk7 bace2-2 bace2-2 bbs4-2 bbs4-2 cd40 cd40 atp6v0a2-2 atp6v0a2-2 SUPT6H SUPT6H nfatc2 nfatc2 NSD2 NSD2 mlh1 mlh1 parp3 parp3 tirap tirap PAWR PAWR xbp1 xbp1 cd74 cd74 ptpn6 ptpn6 tnfsf13b tnfsf13b LOC100491693 LOC100491693 stat5b stat5b kmt5b kmt5b tnfrsf21 tnfrsf21 TP53BP1 TP53BP1 hmces hmces zfp36l2 zfp36l2 tgfb1 tgfb1 FOXP3 FOXP3 pcid2 pcid2 il10 il10 Il6 Il6 wdr1 wdr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smarcal1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity); Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (941 aa)
ENSXETP00000054108RNase_PH domain-containing protein. (199 aa)
cyb5b-2Cytochrome b5 type B (outer mitochondrial membrane); Belongs to the Toll-like receptor family. (1024 aa)
ppp2r3cSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Possible role in the regulation of cell death. (448 aa)
tbx21Leucine rich repeat containing 3B. (561 aa)
morn5MORN repeat-containing protein 5. (178 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
sash3Novel protein similar to sly (CXorf9). (389 aa)
samsn1Ankyrin repeat and SOCS box containing 7. (388 aa)
THOC1THO complex 1. (671 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
fkbp10-2FKBP prolyl isomerase 10. (263 aa)
lynTyrosine-protein kinase. (524 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
asxl3-2ASXL transcriptional regulator 3. (584 aa)
IKZF3IKAROS family zinc finger 3. (504 aa)
sykTyrosine-protein kinase. (611 aa)
stat6Signal transducer and activator of transcription. (787 aa)
badSMC5-SMC6 complex localization factor 1. (151 aa)
ENSXETP00000035998RNase_PH domain-containing protein. (207 aa)
ENSXETP00000034089RNase_PH domain-containing protein. (188 aa)
akirin2Zinc finger and BTB domain-containing 12. (181 aa)
ccdc122WD repeat domain 36. (208 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
peli2PHD finger protein 5A. (418 aa)
mmp14ZnMc domain-containing protein. (622 aa)
EXOSC3Exosome component 3. (250 aa)
cd38Fc receptor, IgG, high affinity I. (300 aa)
LOC101733556Sorcin. (303 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
snrpb2-3Small nuclear ribonucleoprotein polypeptide B. (115 aa)
RIF1Replication timing regulatory factor 1. (2264 aa)
kdelr2-2ER lumen protein-retaining receptor 2. (205 aa)
ENSXETP00000001570Mediator of RNA polymerase II transcription subunit 8. (574 aa)
clcf1Cardiotrophin-like cytokine factor 1. (223 aa)
atad5Dipeptidyl-peptidase 6. (1728 aa)
nup214-2Uncharacterized protein. (162 aa)
ENSXETP00000003176RNase_PH domain-containing protein. (228 aa)
il27raUncharacterized protein. (473 aa)
blkTyrosine-protein kinase. (497 aa)
itih5-2Leucine rich repeat containing 41. (180 aa)
phactr1-2Ig-like domain-containing protein. (123 aa)
hsd17b2Hydroxysteroid (17-beta) dehydrogenase 2. (120 aa)
ENSXETP00000004837Ig-like domain-containing protein. (124 aa)
ENSXETP00000004850Ig-like domain-containing protein. (124 aa)
plcxd3Phosphatidylinositol-specific phospholipase C, X domain containing 3. (141 aa)
acly-2Pituitary tumor-transforming 1 interacting protein, gene 2. (517 aa)
F7CYZ3_XENTRUncharacterized protein. (224 aa)
tyrobpTrafficking protein particle complex 1. (104 aa)
kmt5cLOC100145748 protein. (772 aa)
ptk7Protein tyrosine kinase 7 (inactive). (697 aa)
bace2-2Purinergic receptor P2X, ligand gated ion channel, 2. (177 aa)
bbs4-2RNase_PH domain-containing protein. (221 aa)
cd40CD40. (279 aa)
atp6v0a2-2Reticulophagy regulator family member 2. (201 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1728 aa)
nfatc2ADP-ribosylation factor-like protein 8A. (900 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1308 aa)
mlh1Mitochondrial ribosomal protein L1. (758 aa)
parp3Poly [ADP-ribose] polymerase. (544 aa)
tirapTIR domain-containing protein. (547 aa)
PAWRPro-apoptotic WT1 regulator. (344 aa)
xbp1Destrin, actin depolymerizing factor. (349 aa)
cd74Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
tnfsf13bRegulatory factor X associated protein; Belongs to the tumor necrosis factor family. (266 aa)
LOC100491693TIR domain-containing protein. (505 aa)
stat5bSignal transducer and activator of transcription. (834 aa)
kmt5bClathrin interactor 1. (844 aa)
tnfrsf21Uncharacterized protein. (615 aa)
TP53BP1Tumor protein p53 binding protein 1. (2185 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (335 aa)
zfp36l2mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-con [...] (362 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FOXP3Forkhead box P3. (412 aa)
pcid2Novel protein, containing PCI domain. (399 aa)
il10Activating transcription factor 6. (172 aa)
Il6Uncharacterized protein. (150 aa)
wdr1WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity); Belongs to the WD repeat AIP1 family. (609 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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