(95 nodes) Leukocyte migration network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	asb2	Pantothenate kinase 2. (652 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1030 aa)
	cxadr	Uncharacterized protein. (362 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1046 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1365 aa)
	tbx21	Leucine rich repeat containing 3B. (561 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (538 aa)
	cyp7b1	V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K; Belongs to the cytochrome P450 family. (491 aa)
	jagn1	Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Belongs to the jagunal family. (183 aa)
	il17rc	SEFIR domain-containing protein. (762 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2040 aa)
	add2	Aldolase_II domain-containing protein. (725 aa)
	lgals3	Galectin. (256 aa)
	TAFA4	TAFA chemokine like family member 4. (221 aa)
	NKX2-3	Homeobox domain-containing protein. (328 aa)
	JAM3	Junctional adhesion molecule 3. (298 aa)
	CD34	Uncharacterized protein. (329 aa)
	kctd1	Potassium channel tetramerization domain containing 1. (302 aa)
	ednrb	Aconitase 2; Belongs to the G-protein coupled receptor 1 family. (433 aa)
	galns-2	Galactosamine (N-acetyl)-6-sulfatase. (784 aa)
	mmp9.1	Uncharacterized protein. (692 aa)
	ffar3	Amylase, alpha 2B (pancreatic); Belongs to the G-protein coupled receptor 1 family. (322 aa)
	FFAR2	Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	anxa1.3	Annexin. (350 aa)
	cd99	Solute carrier family 22 member 5. (198 aa)
	ENSXETP00000010908	Ig-like domain-containing protein. (209 aa)
	polr3b-2	Uncharacterized protein. (271 aa)
	itga1	Tetratricopeptide repeat domain 37; Belongs to the integrin alpha chain family. (1132 aa)
	crk	Multivesicular body subunit 12B. (297 aa)
	scg2	BRX1, biogenesis of ribosomes. (624 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (290 aa)
	itga7	RIB43A domain with coiled-coils 2; Belongs to the integrin alpha chain family. (1155 aa)
	NF1	Neurofibromin 1. (2812 aa)
	pdgfb-2	Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
	dtnb-2	Dystrobrevin beta. (329 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	LOC101733412	EPS8 like 1. (594 aa)
	nedd9	Sterol regulatory element binding transcription factor 1. (782 aa)
	podxl2	MOB kinase activator 1A. (521 aa)
	edn2	Mesoderm induction early response 1, family member 2. (168 aa)
	dbh	Ectodermal-neural cortex (with BTB-like domain), gene 2. (615 aa)
	irak4	Irak4 protein. (457 aa)
	pecam1	Uncharacterized protein. (726 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	golph3	Golgi phosphoprotein 3 (Coat-protein). (290 aa)
	aimp1	tRNA-binding domain-containing protein. (313 aa)
	slc37a4	MFS domain-containing protein. (505 aa)
	ptpro	ORMDL sphingolipid biosynthesis regulator 1. (1018 aa)
	msn	Homogentisate 1,2-dioxygenase. (591 aa)
	ENSXETP00000026598	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	jam2	Junctional adhesion molecule 2. (295 aa)
	Ccl20	C-C motif chemokine. (85 aa)
	csf3r	Uncharacterized protein. (808 aa)
	galnt10-2	Polypeptide N-acetylgalactosaminyltransferase 10. (601 aa)
	umodl1	Uncharacterized protein. (1110 aa)
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
	pikfyve	Uncharacterized protein. (2104 aa)
	adat2	tRNA-specific adenosine deaminase 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs. (175 aa)
	itga6	Serine/arginine repetitive matrix 2; Belongs to the integrin alpha chain family. (1095 aa)
	mcoln2	Janus kinase and microtubule interacting protein 1. (581 aa)
	zdhhc14	Zinc finger DHHC-type containing 14. (332 aa)
	prps1-2	Uncharacterized protein. (455 aa)
	ENSXETP00000032157	Ion_trans domain-containing protein. (263 aa)
	anxa1.1	Annexin. (675 aa)
	bsg	Solute carrier family 25 member 13. (410 aa)
	slc7a2.2-2	Uncoupling protein 1. (1393 aa)
	cxcr3	Chemokine (C-X-C motif) receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1254 aa)
	rabgef1	SET nuclear proto-oncogene. (538 aa)
	LOC101732232	Stanniocalcin 2. (513 aa)
	pparg-2	Collagen type XI alpha 2 pseudogene 1. (511 aa)
	LOC101732121	Uncharacterized protein. (268 aa)
	thdl18	Novel protein similar to xl18. (431 aa)
	LOC101732853	ZP domain-containing protein. (433 aa)
	ror2	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	syk	Tyrosine-protein kinase. (611 aa)
	gbf1	Olfactory receptor class II (xb178 gene). (1854 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (171 aa)
	agk	Acylglycerol kinase. (592 aa)
	dclk2	Uncharacterized protein. (590 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1045 aa)
	ENSXETP00000040926	Uncharacterized protein. (514 aa)
	ENSXETP00000040990	Uncharacterized protein. (607 aa)
	UMOD	Uncharacterized protein. (566 aa)
	ptn	Glycine receptor alpha 3. (190 aa)
	ednrb2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	gas6	Homeobox protein CDX-1. (672 aa)
	kdrl	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1015 aa)
	flt1	Keratin 18, gene 2. (970 aa)
	cxcl9	Cyclin-dependent kinase 2 associated protein 2. (96 aa)
	gata3	Uncharacterized protein. (454 aa)
	ppib	Antizyme inhibitor 1. (301 aa)
	ANO6	Anoctamin. (909 aa)
	tnf	Thyrotropin-releasing hormone receptor 3. (227 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR6	Ccl20	ENSXETP00000048989	ENSXETP00000027790	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.983
CCR6	cxcl9	ENSXETP00000048989	ENSXETP00000044932	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.405
CCR7	CD34	ENSXETP00000023102	ENSXETP00000008122	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.461
CCR7	CXCR5	ENSXETP00000023102	ENSXETP00000019894	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.626
CCR7	Ccl20	ENSXETP00000023102	ENSXETP00000027790	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.583
CCR7	ITGA4	ENSXETP00000023102	ENSXETP00000047171	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.437
CCR7	cxcl9	ENSXETP00000023102	ENSXETP00000044932	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.726
CCR7	tbx21	ENSXETP00000023102	ENSXETP00000050522	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Leucine rich repeat containing 3B.	0.431
CD34	CCR7	ENSXETP00000008122	ENSXETP00000023102	Uncharacterized protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.461
CD34	cd99	ENSXETP00000008122	ENSXETP00000010848	Uncharacterized protein.	Solute carrier family 22 member 5.	0.537
CD34	kit	ENSXETP00000008122	ENSXETP00000030352	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.772
CD34	pecam1	ENSXETP00000008122	ENSXETP00000022849	Uncharacterized protein.	Uncharacterized protein.	0.656
CD34	prps1-2	ENSXETP00000008122	ENSXETP00000032095	Uncharacterized protein.	Uncharacterized protein.	0.404
CXCR5	CCR7	ENSXETP00000019894	ENSXETP00000023102	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.626
CXCR5	cxcl9	ENSXETP00000019894	ENSXETP00000044932	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	Cyclin-dependent kinase 2 associated protein 2.	0.597
Ccl20	CCR6	ENSXETP00000027790	ENSXETP00000048989	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.983
Ccl20	CCR7	ENSXETP00000027790	ENSXETP00000023102	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.583
Ccl20	TNFSF11	ENSXETP00000027790	ENSXETP00000015617	C-C motif chemokine.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.447
Ccl20	cxcl9	ENSXETP00000027790	ENSXETP00000044932	C-C motif chemokine.	Cyclin-dependent kinase 2 associated protein 2.	0.566
Ccl20	msn	ENSXETP00000027790	ENSXETP00000025775	C-C motif chemokine.	Homogentisate 1,2-dioxygenase.	0.453

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