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cfl1 cfl1 LOC108644441 LOC108644441 gsn gsn gmfb gmfb gmfg gmfg capg capg flii flii dstn dstn avil avil svil svil vill vill scin scin LOC108644475 LOC108644475 vil1 vil1 dnajc2 dnajc2 cfl2 cfl2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cfl1Cofilin-1; May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage furrow during cytokinesis. (168 aa)
LOC108644441Gelsolin-like domain-containing protein. (124 aa)
gsnUncharacterized protein. (744 aa)
gmfbGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (143 aa)
gmfgADF-H domain-containing protein. (61 aa)
capgProtein kinase C and casein kinase substrate in neurons 2. (347 aa)
fliiRas and Rab interactor 2. (1274 aa)
dstnSolute carrier family 1 member 2; Belongs to the actin-binding proteins ADF family. (153 aa)
avil1-acylglycerol-3-phosphate O-acyltransferase 2. (807 aa)
svilCoiled-coil domain containing 181. (2279 aa)
villJAZF zinc finger 1. (876 aa)
scinKinetochore protein NDC80 homolog. (761 aa)
LOC108644475SH3 and PX domains 2B. (715 aa)
vil1HP domain-containing protein. (713 aa)
dnajc2DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription ac [...] (620 aa)
cfl2Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (167 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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