STRINGSTRING
kif2c kif2c ENSXETP00000000225 ENSXETP00000000225 trappc12 trappc12 eml4 eml4 cenpe cenpe ndc80 ndc80 mis12 mis12 pibf1 pibf1 KIF14 KIF14 mad1l1 mad1l1 gem gem spdl1 spdl1 mlh1 mlh1 mapre1 mapre1 incenp incenp seh1l seh1l cdca5 cdca5 spo11 spo11 cul3 cul3 vps4a vps4a terb2 terb2 cenpc cenpc mbnl3 mbnl3 pinx1 pinx1 zw10 zw10 kif18a kif18a ndel1 ndel1 chmp6 chmp6 nudc nudc CDT1 CDT1 CENPF CENPF LOC100488959 LOC100488959 vps4b vps4b Terb1 Terb1 nuf2 nuf2 spice1 spice1 ankrd53 ankrd53 ATM ATM FAM83D FAM83D SUN1 SUN1 meioc meioc bub1-2 bub1-2 cdc23 cdc23 KPNB1 KPNB1 nde1 nde1 rrs1 rrs1 rmdn1 rmdn1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kif2cKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (715 aa)
ENSXETP00000000225Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (64 aa)
trappc12Sprouty RTK signaling antagonist 1. (777 aa)
eml4Echinoderm microtubule-associated protein-like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. (1028 aa)
cenpeKinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (3296 aa)
ndc80Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa)
mis12Uncharacterized protein. (221 aa)
pibf1Uncharacterized protein. (755 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1411 aa)
mad1l1Neutrophil cytosolic factor 4. (605 aa)
gemPleckstrin homology and FYVE domain containing 2. (299 aa)
spdl1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity); Belongs to the Spindly family. (611 aa)
mlh1Mitochondrial ribosomal protein L1. (758 aa)
mapre1Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. (302 aa)
incenpInner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within [...] (924 aa)
seh1lNucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. (383 aa)
cdca5LOC100145078 protein. (274 aa)
spo11TP6A_N domain-containing protein. (396 aa)
cul3Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Involved in ER- Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). May play a role in the regulation of mittotic entry via ubiquitinati [...] (770 aa)
vps4aUncharacterized protein; Belongs to the AAA ATPase family. (462 aa)
terb2Uncharacterized protein. (199 aa)
cenpcCENP-C_C domain-containing protein. (1378 aa)
mbnl3Muscleblind-like splicing regulator 3. (203 aa)
pinx1Leucine rich repeat containing 14. (337 aa)
zw10Uncharacterized protein. (780 aa)
kif18aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (947 aa)
ndel1Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. (345 aa)
chmp6LOC100125185 protein. (200 aa)
nudcNuclear migration protein. (329 aa)
CDT1Chromatin licensing and DNA replication factor 1. (617 aa)
CENPFCentromere protein F. (2609 aa)
LOC100488959Pumilio RNA binding family member 3. (856 aa)
vps4bUncharacterized protein; Belongs to the AAA ATPase family. (501 aa)
Terb1Uncharacterized protein. (329 aa)
nuf2Msh homeobox 1. (462 aa)
spice1ELMO/CED-12 domain containing 2. (785 aa)
ankrd53ANK_REP_REGION domain-containing protein. (410 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
FAM83DFamily with sequence similarity 83 member D. (560 aa)
SUN1Sad1 and UNC84 domain containing 1. (943 aa)
meiocUncharacterized protein. (801 aa)
bub1-2Tumor necrosis factor alpha-induced protein 8. (748 aa)
cdc23Serine/threonine kinase 36. (604 aa)
KPNB1Karyopherin subunit beta 1. (885 aa)
nde1Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle; Belongs to the nudE family. (340 aa)
rrs1Rrs1 protein. (123 aa)
rmdn1Corticotropin releasing hormone receptor 2. (315 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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