STRINGSTRING
tnf tnf edn1 edn1 fdx1 fdx1 cox17 cox17 NOD1 NOD1 rfk rfk LOC100490493 LOC100490493 TACO1 TACO1 pik3cb pik3cb sirt4 sirt4 htr2b htr2b pdp1 pdp1 etfbkmt etfbkmt SIRT3 SIRT3 gdnf gdnf gla gla LOC733765 LOC733765 sdhaf4 sdhaf4 lrrk2 lrrk2 terf2 terf2 edn2 edn2 tert tert fdx2 fdx2 npr3 npr3 sirt3.2 sirt3.2 LOC100490663 LOC100490663 PDPR PDPR LOC100498263 LOC100498263 nus1 nus1 ndufa4 ndufa4 POR POR scarb1 scarb1 ccs ccs lep lep ABL1 ABL1 park7 park7 abl2 abl2 LOC100488346 LOC100488346 fgf23.2 fgf23.2 fgf23.1 fgf23.1 edn3 edn3 LOC100496423 LOC100496423 cav3.2 cav3.2 ecsit ecsit LOC100496565 LOC100496565 dhfr-2 dhfr-2 pdp2 pdp2 cav3.1 cav3.1 esr1 esr1 phkg2-3 phkg2-3 cav1 cav1 coa8 coa8 il1b il1b VDR VDR FXN FXN gch1 gch1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
edn1Nidogen 2. (222 aa)
fdx1Transient receptor potential cation channel, subfamily C, member 6. (167 aa)
cox17Alpha thalassemia/mental retardation syndrome X-linked. (67 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (891 aa)
rfkRegulator of calcineurin 1. (154 aa)
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
TACO1Translational activator of cytochrome c oxidase I. (305 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
sirt4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (322 aa)
htr2bRas homolog family member C. (478 aa)
pdp1PPM-type phosphatase domain-containing protein. (561 aa)
etfbkmtUncharacterized protein. (247 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (358 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (227 aa)
glaAlpha-galactosidase. (408 aa)
LOC733765Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
sdhaf4MGC89089 protein. (118 aa)
lrrk2Hes family bHLH transcription factor 2. (2514 aa)
terf2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (471 aa)
edn2Mesoderm induction early response 1, family member 2. (168 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1196 aa)
fdx22Fe-2S ferredoxin-type domain-containing protein. (193 aa)
npr3Chromosome 20 open reading frame 194. (508 aa)
sirt3.2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (401 aa)
LOC100490663Uncharacterized protein; Belongs to the protein kinase superfamily. (439 aa)
PDPRPyruvate dehydrogenase phosphatase regulatory subunit. (895 aa)
LOC100498263Asparagine synthetase domain containing 1. (178 aa)
nus1PTPRF interacting protein, binding protein 2 (liprin beta 2). (288 aa)
ndufa4Uncharacterized protein. (98 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (703 aa)
scarb1Coagulation factor 12 (Hageman factor); Belongs to the CD36 family. (450 aa)
ccsCopper chaperone for superoxide dismutase. (274 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
ABL1Tyrosine-protein kinase. (1128 aa)
park7Parkinson disease (Autosomal recessive,). (189 aa)
abl2Tyrosine-protein kinase. (1100 aa)
LOC100488346Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1239 aa)
fgf23.2Leucine-rich repeat LGI family member 4; Belongs to the heparin-binding growth factors family. (254 aa)
fgf23.1Uncharacterized protein; Belongs to the heparin-binding growth factors family. (249 aa)
edn3END domain-containing protein. (127 aa)
LOC100496423Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
ecsitEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. (414 aa)
LOC100496565Tektin 3. (228 aa)
dhfr-2DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (189 aa)
pdp2Alpha-(1,3)-fucosyltransferase 10. (536 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
phkg2-3Phosphorylase kinase, gamma 2 (testis). (2236 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
coa8Cas scaffold protein family member 4. (188 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
VDRVitamin D receptor. (420 aa)
FXNFrataxin. (206 aa)
gch1GTP cyclohydrolase 1. (247 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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