STRINGSTRING
rgcc rgcc fgf8 fgf8 cul3 cul3 pdgfb-2 pdgfb-2 lrp5 lrp5 cdc16 cdc16 anapc7 anapc7 BTC BTC npm2 npm2 smpd5l smpd5l nsmce2 nsmce2 il1b il1b cdc23 cdc23 chd7 chd7 smpd3 smpd3 rb1 rb1 ereg ereg epgn epgn CDT1 CDT1 cdc27 cdc27 tgfa tgfa SIRT2 SIRT2 igf2 igf2 anapc5 anapc5 msx1 msx1 edn1 edn1 mad2l1bp mad2l1bp anapc11 anapc11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rgccDual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
cul3Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Involved in ER- Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). May play a role in the regulation of mittotic entry via ubiquitinati [...] (770 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa)
cdc16TPR_REGION domain-containing protein. (612 aa)
anapc7Cyclin E1. (590 aa)
BTCBetacellulin. (170 aa)
npm2Nucleoplasmin domain-containing protein. (203 aa)
smpd5lUncharacterized protein. (523 aa)
nsmce2Ring finger protein 34, E3 ubiquitin protein ligase. (203 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
cdc23Serine/threonine kinase 36. (604 aa)
chd7Chromodomain helicase DNA-binding protein 7. (256 aa)
smpd3Barttin CLCNK-type chloride channel accessory beta subunit. (659 aa)
rb1Uncharacterized protein. (914 aa)
eregNIMA-related kinase 6. (156 aa)
epgnLeucine-rich repeats and calponin homology (CH) domain containing 1. (138 aa)
CDT1Chromatin licensing and DNA replication factor 1. (617 aa)
cdc27Phosphodiesterase 11A. (845 aa)
tgfaSolute carrier family 6 (neurotransmitter transporter), member 8 like. (163 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (414 aa)
igf2IlGF domain-containing protein. (217 aa)
anapc5ANAPC5 domain-containing protein. (743 aa)
msx1Potassium channel, two pore domain subfamily K, member 18. (275 aa)
edn1Nidogen 2. (222 aa)
mad2l1bpPoly(ADP-ribose) polymerase family member 6. (247 aa)
anapc11Guanine nucleotide binding protein (G protein), beta polypeptide 1-like. (84 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.