STRINGSTRING
DLL4 DLL4 WNT2 WNT2 hand1 hand1 zfpm1 zfpm1 tcap tcap WNT2B WNT2B ednra ednra ptcd2 ptcd2 tnnc1 tnnc1 tgfbr1 tgfbr1 nkx2-5 nkx2-5 smad4.1 smad4.1 eng eng tgfb1 tgfb1 tnni3 tnni3 Tnni1 Tnni1 SMAD7 SMAD7 med1l med1l zfpm2 zfpm2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
hand1Glycogen synthase kinase 3 beta. (213 aa)
zfpm1C-terminal Src kinase. (1214 aa)
tcapDNA topoisomerase II alpha. (186 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
ednraEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (414 aa)
ptcd2Uncharacterized protein. (382 aa)
tnnc1CTD small phosphatase like. (161 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
nkx2-5Toll-like receptor12. (300 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
engUncharacterized protein. (622 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
tnni3Transmembrane protein 256. (245 aa)
Tnni1Uncharacterized protein. (152 aa)
SMAD7Mothers against decapentaplegic homolog. (382 aa)
med1lMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (678 aa)
zfpm2GPI mannosyltransferase 1. (1151 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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