STRINGSTRING
ehd1 ehd1 tnf tnf rab11fip5 rab11fip5 scamp5.1 scamp5.1 optn optn tpcn1 tpcn1 vps53 vps53 washc1 washc1 pdlim4 pdlim4 inpp5f inpp5f slc9a7 slc9a7 rab11a rab11a vti1b vti1b ehd4 ehd4 unc13d unc13d itsn1 itsn1 rab8a rab8a arf6 arf6 ldlrap1 ldlrap1 rab14 rab14 kcnk1 kcnk1 relch relch neu3 neu3 RAB12 RAB12 dennd6b dennd6b mlc1 mlc1 ptk7 ptk7 ACKR4 ACKR4 rep15 rep15 LOC100494483 LOC100494483 LOC101730879 LOC101730879 abhd17b abhd17b pacsin2 pacsin2 slc31a2 slc31a2 sorcs2 sorcs2 tf tf lztr1 lztr1 vps50 vps50 rabep1 rabep1 ATP13A3 ATP13A3 vamp3 vamp3 ENSXETP00000016356 ENSXETP00000016356 vars2-2 vars2-2 vps51 vps51 tubgcp4 tubgcp4 lamp5 lamp5 ehd2 ehd2 atp11c atp11c ndrg4 ndrg4 ENSXETP00000021488 ENSXETP00000021488 atp11a atp11a cmtm6 cmtm6 atg9a atg9a rab4b rab4b gpr161 gpr161 nsg1 nsg1 rab11fip3 rab11fip3 vps16 vps16 app app rnf11 rnf11 ATP11B ATP11B clip3 clip3 scamp2 scamp2 LOC100495031 LOC100495031 rab29 rab29 LOC100135070 LOC100135070 arfgef2 arfgef2 pheta2 pheta2 SLC9A9 SLC9A9 rab11fip4l rab11fip4l ehd3 ehd3 atg9b atg9b rap2b rap2b zfyve27 zfyve27 rnf11.2 rnf11.2 plekhb2 plekhb2 neu3.2 neu3.2 abhd12 abhd12 mcoln2 mcoln2 slc26a7 slc26a7 tmem230 tmem230 fchsd2 fchsd2 clcn3 clcn3 scamp1 scamp1 Syt11 Syt11 LOC101734947 LOC101734947 ENSXETP00000034327 ENSXETP00000034327 Nisch Nisch rab13 rab13 LOC100498468 LOC100498468 ENSXETP00000035306 ENSXETP00000035306 sorl1 sorl1 abhd17a abhd17a plekhj1 plekhj1 AMOTL2 AMOTL2 vamp8 vamp8 gria1 gria1 fchsd1 fchsd1 rab11b.2 rab11b.2 rab11b.1 rab11b.1 rabgef1 rabgef1 vipas39 vipas39 MELTF MELTF tbc1d14 tbc1d14 avl9 avl9 sh3tc1 sh3tc1 cln3 cln3 LOC100498607 LOC100498607 sh3tc2 sh3tc2 micall1 micall1 rab25 rab25 vps33b vps33b RAB11FIP1 RAB11FIP1 RASSF9 RASSF9 stx7 stx7 gper1 gper1 bok bok ENSXETP00000044516 ENSXETP00000044516 gga3 gga3 ak4 ak4 micall2 micall2 chmp5 chmp5 commd1 commd1 cdk12 cdk12 rap2a rap2a inpp4a inpp4a VPS52 VPS52 kcnk7 kcnk7 stx8 stx8 Slc30a10 Slc30a10 rap2c rap2c abhd17c abhd17c rab15 rab15 cftr cftr dennd6a dennd6a SLC9A6 SLC9A6 rab8b rab8b st8sia2 st8sia2 ackr3 ackr3 entr1 entr1 SGK3 SGK3 sptssa sptssa SLC1A1 SLC1A1 stx12 stx12
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ehd1Nuclear factor, erythroid 2 like 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
rab11fip5Uncharacterized protein. (1534 aa)
scamp5.1Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines. Probably acts in cooperation with the SNARE machinery (By similarity); Belongs to the SCAMP family. SCAMP5 subfamily. (235 aa)
optnFatty acid binding protein 6, ileal. (553 aa)
tpcn1DDB1 and CUL4 associated factor 15. (750 aa)
vps53Retinoid X receptor gamma. (830 aa)
washc1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (472 aa)
pdlim4Phosphoserine aminotransferase 1. (332 aa)
inpp5fSpermatogenesis associated 13. (1077 aa)
slc9a7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (710 aa)
rab11aRAB11A, member RAS oncogene family. (216 aa)
vti1bt-SNARE coiled-coil homology domain-containing protein. (221 aa)
ehd4Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (537 aa)
unc13dSerine/threonine-protein phosphatase CPPED1. (1105 aa)
itsn1Thiamin pyrophosphokinase 1. (1710 aa)
rab8aChloride channel, voltage-sensitive 7. (220 aa)
arf6Solute carrier family 8 (sodium/calcium exchanger), member 1; Belongs to the small GTPase superfamily. Arf family. (229 aa)
ldlrap1Zinc finger protein 238, gene 2. (309 aa)
rab14Uncharacterized protein. (214 aa)
kcnk1Potassium channel subfamily K member. (331 aa)
relchRAB11-binding protein RELCH homolog; May regulate intracellular cholesterol transport. (1220 aa)
neu3Treacher Collins-Franceschetti syndrome 1. (397 aa)
RAB12RAB12, member RAS oncogene family. (248 aa)
dennd6bBCL11B, BAF complex component. (533 aa)
mlc1Megalencephalic leukoencephalopathy with subcortical cysts 1 gene product. (377 aa)
ptk7Protein tyrosine kinase 7 (inactive). (697 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
rep15Olfactory receptor family 2 subfamily G member 3. (234 aa)
LOC100494483Endoribonuclease LACTB2. (256 aa)
LOC101730879PhoLip_ATPase_N domain-containing protein. (175 aa)
abhd17bAlpha/beta hydrolase domain-containing protein 17B; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins; Belongs to the AB hydrolase superfamily. ABHD17 family. (288 aa)
pacsin2Protein kinase C and casein kinase substrate in neurons 2. (477 aa)
slc31a2Tax1-binding protein 1 homolog. (191 aa)
sorcs2Guanylate binding protein 4. (1090 aa)
tfSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (739 aa)
lztr1Uncharacterized protein. (804 aa)
vps50Ccdc132 protein. (964 aa)
rabep1Anterior and ectodermic-specific protein. (857 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1247 aa)
vamp3V-SNARE coiled-coil homology domain-containing protein. (118 aa)
ENSXETP00000016356Uncharacterized protein. (93 aa)
vars2-2Valyl-tRNA synthetase 2, mitochondrial. (60 aa)
vps51Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. (782 aa)
tubgcp4Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (669 aa)
lamp5Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. (276 aa)
ehd2MGC107790 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (538 aa)
atp11cPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1130 aa)
ndrg4Protein NDRG4; Contributes to the maintenance of intracerebral BDNF levels within the normal range. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate growth factor-promoted ELK1 phosphorylation in a microtubule-dependent manner (By similarity). Belongs to the NDRG family. (407 aa)
ENSXETP00000021488Uncharacterized protein. (877 aa)
atp11aPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1194 aa)
cmtm6Uncharacterized protein. (172 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (1099 aa)
rab4bRAB4B, member RAS oncogene family. (213 aa)
gpr161G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity); Belongs to the G-protein coupled receptor 1 family. (521 aa)
nsg1DDB1- and CUL4-associated factor 13. (185 aa)
rab11fip3N-acetyltransferase 10 (GCN5-related). (988 aa)
vps16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (834 aa)
appGeneral transcription factor IIE subunit 2. (769 aa)
rnf11Ubiquitin carboxyl-terminal hydrolase 44. (220 aa)
ATP11BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1168 aa)
clip3ANTXR cell adhesion molecule 1. (534 aa)
scamp2Secretory carrier-associated membrane protein. (330 aa)
LOC100495031Uncharacterized protein. (779 aa)
rab29LOC100135159 protein. (204 aa)
LOC100135070SH3-domain-binding protein 2. (309 aa)
arfgef2Dopamine receptor D2. (1792 aa)
pheta2PH domain containing endocytic trafficking adaptor 2. (249 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (630 aa)
rab11fip4lTubulin epsilon 1. (406 aa)
ehd3Dual specificity tyrosine phosphorylation regulated kinase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (551 aa)
atg9bAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (768 aa)
rap2bRAP2B, member of RAS oncogene family. (182 aa)
zfyve27Cell division cycle associated 4. (445 aa)
rnf11.2Y+L amino acid transporter 2. (146 aa)
plekhb2Protein associated with topoisomerase II homolog 1. (243 aa)
neu3.2Histone cluster 1, H2aa. (374 aa)
abhd12Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (437 aa)
mcoln2Janus kinase and microtubule interacting protein 1. (581 aa)
slc26a7Anion exchange transporter. (613 aa)
tmem230MGC89669 protein. (120 aa)
fchsd2Transmembrane protein 209. (774 aa)
clcn3Chloride channel protein. (867 aa)
scamp1Secretory carrier-associated membrane protein. (355 aa)
Syt11Synaptotagmin 11. (295 aa)
LOC101734947Chemokine (C-X-C motif) receptor 6. (94 aa)
ENSXETP00000034327PH domain-containing protein. (171 aa)
NischUncharacterized protein. (196 aa)
rab13Pleckstrin homology-like domain, family B, member 3. (143 aa)
LOC100498468Uncharacterized protein. (471 aa)
ENSXETP00000035306PH domain-containing protein. (231 aa)
sorl1Tubulin tyrosine ligase like 4. (2146 aa)
abhd17aHypothetical LOC496639. (305 aa)
plekhj1Pleckstrin homology domain-containing family J member 1. (188 aa)
AMOTL2Angiomotin like 2. (717 aa)
vamp8Putative ferric-chelate reductase 1. (107 aa)
gria1TRAF3 interacting protein 2. (903 aa)
fchsd1Cartilage intermediate layer protein 2. (665 aa)
rab11b.2Human immunodeficiency virus type I enhancer binding protein 3. (218 aa)
rab11b.1Leucine rich repeat containing 8 VRAC subunit A. (221 aa)
rabgef1SET nuclear proto-oncogene. (538 aa)
vipas39Vps16_C domain-containing protein. (463 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (703 aa)
tbc1d14Potassium channel, voltage gated modifier subfamily G, member 2. (794 aa)
avl9UDENN domain-containing protein. (641 aa)
sh3tc1Rhomboid domain containing 1. (1218 aa)
cln3Uncharacterized protein. (579 aa)
LOC100498607Delta(4)-desaturase, sphingolipid 2; Belongs to the transferrin family. (752 aa)
sh3tc2Potassium channel tetramerization domain containing 14. (1243 aa)
micall1Tetratricopeptide repeat domain 14. (775 aa)
rab25RAB25, member RAS oncogene family. (216 aa)
vps33bUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (612 aa)
RAB11FIP1RAB11 family interacting protein 1. (1056 aa)
RASSF9Ras association domain family member 9. (422 aa)
stx7NAD-dependent protein deacylase sirtuin-5, mitochondrial. (280 aa)
gper1Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
bokPlexin A1. (214 aa)
ENSXETP00000044516Uncharacterized protein. (128 aa)
gga3Uncharacterized protein. (706 aa)
ak4Adenylate kinase 4. (887 aa)
micall2Discs large homolog 5. (1023 aa)
chmp5Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (240 aa)
commd1Protein serine kinase H1. (187 aa)
cdk12Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating srsf1/sf2 (By similarity). (1466 aa)
rap2aRAP2A, member of RAS oncogene family. (183 aa)
inpp4aUncharacterized protein. (972 aa)
VPS52VPS52 subunit of GARP complex. (728 aa)
kcnk7Potassium channel subfamily K member. (322 aa)
stx8t-SNARE coiled-coil homology domain-containing protein. (272 aa)
Slc30a10Uncharacterized protein. (123 aa)
rap2cRAP2C, member of RAS oncogene family. (183 aa)
abhd17cAlpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins; Belongs to the AB hydrolase superfamily. ABHD17 family. (310 aa)
rab15RAB15, member RAS onocogene family. (212 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
dennd6aBMP binding endothelial regulator. (556 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (707 aa)
rab8bPBX/knotted 1 homeobox 2. (207 aa)
st8sia2Ras-related associated with diabetes; Belongs to the glycosyltransferase 29 family. (370 aa)
ackr3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (361 aa)
entr1Endosome-associated-trafficking regulator 1; Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Belongs to the ENTR1 family. (346 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
sptssaSerine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity). Belongs to the SPTSS family. SPTSSA subfamily. (80 aa)
SLC1A1Amino acid transporter. (529 aa)
stx12Decaprenyl diphosphate synthase subunit 1; Belongs to the syntaxin family. (288 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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