(22 nodes) Negative regulation of necrotic cell death network (Xenopus tropicalis)

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Your Input:
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	adprhl2	ADP-ribose glycohydrolase ARH3; ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different substrates, such as proteins ADP- ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP- ribosylation of proteins constitutes the primary form of ADP- ribosylation of proteins i [...] (350 aa)
	mutyh	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (532 aa)
	casp10	Casp10 protein; Belongs to the peptidase C14A family. (519 aa)
	casp8	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
	rbck1	RING-type domain-containing protein. (282 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (856 aa)
	ybx3	Cold shock domain protein A. (248 aa)
	ripk1	Sequestosome 1. (669 aa)
	selenof-2	Selenoprotein F. (1185 aa)
	ENSXETP00000014867	FIIND domain-containing protein. (1096 aa)
	ENSXETP00000014912	Uncharacterized protein. (385 aa)
	ddr2l	Discoidin domain receptor family, member 2. (879 aa)
	LOC733765	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	fadd	Zinc finger, NFX1-type containing 1, gene 2. (188 aa)
	peli2	PHD finger protein 5A. (418 aa)
	skp1-2	S-phase kinase-associated protein 1. (769 aa)
	rnf31	Uncharacterized protein. (1034 aa)
	birc2	CREB3 regulatory factor. (639 aa)
	cav3.2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	bok	Plexin A1. (214 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXETP00000014867	ripk1	ENSXETP00000014867	ENSXETP00000011365	FIIND domain-containing protein.	Sequestosome 1.	0.524
ENSXETP00000014912	ripk1	ENSXETP00000014912	ENSXETP00000011365	Uncharacterized protein.	Sequestosome 1.	0.524
LOC733765	cav1	ENSXETP00000016352	ENSXETP00000048942	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
LOC733765	cav3.1	ENSXETP00000016352	ENSXETP00000046948	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
LOC733765	cav3.2	ENSXETP00000016352	ENSXETP00000039803	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
birc2	fadd	ENSXETP00000037887	ENSXETP00000025713	CREB3 regulatory factor.	Zinc finger, NFX1-type containing 1, gene 2.	0.926
birc2	rbck1	ENSXETP00000037887	ENSXETP00000008011	CREB3 regulatory factor.	RING-type domain-containing protein.	0.914
birc2	ripk1	ENSXETP00000037887	ENSXETP00000011365	CREB3 regulatory factor.	Sequestosome 1.	0.950
birc2	rnf31	ENSXETP00000037887	ENSXETP00000037137	CREB3 regulatory factor.	Uncharacterized protein.	0.930
casp10	casp8	ENSXETP00000006082	ENSXETP00000006109	Casp10 protein; Belongs to the peptidase C14A family.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.815
casp10	fadd	ENSXETP00000006082	ENSXETP00000025713	Casp10 protein; Belongs to the peptidase C14A family.	Zinc finger, NFX1-type containing 1, gene 2.	0.986
casp10	ripk1	ENSXETP00000006082	ENSXETP00000011365	Casp10 protein; Belongs to the peptidase C14A family.	Sequestosome 1.	0.853
casp8	casp10	ENSXETP00000006109	ENSXETP00000006082	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	Casp10 protein; Belongs to the peptidase C14A family.	0.815
casp8	fadd	ENSXETP00000006109	ENSXETP00000025713	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	Zinc finger, NFX1-type containing 1, gene 2.	0.989
casp8	ripk1	ENSXETP00000006109	ENSXETP00000011365	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	Sequestosome 1.	0.990
cav1	LOC733765	ENSXETP00000048942	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
cav3.1	LOC733765	ENSXETP00000046948	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
cav3.2	LOC733765	ENSXETP00000039803	ENSXETP00000016352	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.448
fadd	birc2	ENSXETP00000025713	ENSXETP00000037887	Zinc finger, NFX1-type containing 1, gene 2.	CREB3 regulatory factor.	0.926
fadd	casp10	ENSXETP00000025713	ENSXETP00000006082	Zinc finger, NFX1-type containing 1, gene 2.	Casp10 protein; Belongs to the peptidase C14A family.	0.986

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