STRINGSTRING
esr1 esr1 stat3.2 stat3.2 bcdin3d bcdin3d fmr1 fmr1 pum1 pum1 mael mael ripk1 ripk1 TRIM71 TRIM71 tnf tnf zc3h10 zc3h10 tp53 tp53 dnd1 dnd1 ddx5 ddx5 lin28b lin28b fxr1 fxr1 dhx9 dhx9 zmpste24 zmpste24 ncor2 ncor2 TRUB1 TRUB1 PUM2 PUM2 limd1 limd1 Il6 Il6 stat3.1 stat3.1 Zc3h12a Zc3h12a idi1-2 idi1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
bcdin3dTwinfilin actin binding protein 2. (257 aa)
fmr1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250|UniProtKB:P51113, ECO:0000250|UniProtKB:Q06787. (590 aa)
pum1Autophagy/beclin-1 regulator 1. (1171 aa)
maelProtein maelstrom homolog; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic n [...] (415 aa)
ripk1Sequestosome 1. (669 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development. (853 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
zc3h10Zinc finger CCCH-type containing 10. (408 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
dnd1Dead end homolog 1 (Zebrafish). (373 aa)
ddx5Uncharacterized protein; Belongs to the DEAD box helicase family. (618 aa)
lin28bCCHC-type domain-containing protein. (277 aa)
fxr1Fragile X mental retardation syndrome-related protein 1 homolog; RNA-binding protein. Binds poly(G) and poly(U) but not poly(A) or poly(C). Regulates somite formation, probably by regulating gene expression (By similarity). (674 aa)
dhx9U4/U6 small nuclear ribonucleoprotein Prp31. (1257 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
ncor2EPH receptor A4. (2455 aa)
TRUB1TruB pseudouridine synthase family member 1. (291 aa)
PUM2Pumilio RNA binding family member 2. (1192 aa)
limd1LIM domain-containing protein 1; Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development. (589 aa)
Il6Uncharacterized protein. (150 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
Zc3h12aC3H1-type domain-containing protein. (349 aa)
idi1-2Isopentenyl-diphosphate delta isomerase 1. (290 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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