(29 nodes) Regulation of dendritic spine development network (Xenopus tropicalis)

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Predicted Interactions

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Your Input:
	mapk6	Protein phosphatase 2, catalytic subunit, beta isozyme. (720 aa)
	caprin2	Amphibian RCA protein 3. (1012 aa)
	reln	G protein-coupled receptor 119. (3463 aa)
	ube3a	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (908 aa)
	itpka	Kinase; Belongs to the inositol phosphokinase (IPK) family. (470 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1971 aa)
	dbnl	Adaptor related protein complex 2 subunit sigma 1. (455 aa)
	dtnbp1	Nuclear receptor coactivator 1. (355 aa)
	eef2k	Neuraminidase 4 (sialidase). (777 aa)
	grin3a	Nucleoporin 155kDa; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1124 aa)
	arf6	Solute carrier family 8 (sodium/calcium exchanger), member 1; Belongs to the small GTPase superfamily. Arf family. (229 aa)
	cpeb3	Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). Does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). Inhibits differentiation of intermediate mes [...] (603 aa)
	efna1	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (146 aa)
	llph	Protein LLP homolog; Regulates dendritic and spine growth and synaptic transmission; Belongs to the learning-associated protein family. (123 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
	fmr1	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787. (590 aa)
	caprin1	Leucine rich repeat containing 45. (675 aa)
	TANC2	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (2064 aa)
	LOC100490156	C2 calcium-dependent domain containing 4C. (535 aa)
	c21orf91	LOC100170454 protein. (293 aa)
	neurl1	Neurl protein. (555 aa)
	baiap2	Uncharacterized protein. (554 aa)
	DHX36	DEAH-box helicase 36. (1006 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (691 aa)
	dbn1	ADF-H domain-containing protein. (665 aa)
	mapkapk5	Protein kinase domain-containing protein. (494 aa)
	cux2	Homeobox protein cut-like. (1498 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1900 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1850 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHANK1	SHANK3	ENSXETP00000035860	ENSXETP00000039894	SH3 and multiple ankyrin repeat domains 1.	SH3 and multiple ankyrin repeat domains 3.	0.547
SHANK1	baiap2	ENSXETP00000035860	ENSXETP00000027421	SH3 and multiple ankyrin repeat domains 1.	Uncharacterized protein.	0.437
SHANK3	SHANK1	ENSXETP00000039894	ENSXETP00000035860	SH3 and multiple ankyrin repeat domains 3.	SH3 and multiple ankyrin repeat domains 1.	0.547
SHANK3	baiap2	ENSXETP00000039894	ENSXETP00000027421	SH3 and multiple ankyrin repeat domains 3.	Uncharacterized protein.	0.552
SHANK3	fmr1	ENSXETP00000039894	ENSXETP00000015179	SH3 and multiple ankyrin repeat domains 3.	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	0.564
baiap2	SHANK1	ENSXETP00000027421	ENSXETP00000035860	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 1.	0.437
baiap2	SHANK3	ENSXETP00000027421	ENSXETP00000039894	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 3.	0.552
c21orf91	neurl1	ENSXETP00000025518	ENSXETP00000026595	LOC100170454 protein.	Neurl protein.	0.647
caprin1	fmr1	ENSXETP00000016366	ENSXETP00000015179	Leucine rich repeat containing 45.	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	0.679
caprin2	fmr1	ENSXETP00000045707	ENSXETP00000015179	Amphibian RCA protein 3.	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	0.538
cpeb3	fmr1	ENSXETP00000011081	ENSXETP00000015179	Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). Does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). Inhibits differentiation of intermediate mes [...]	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	0.494
cux2	neurl1	ENSXETP00000035221	ENSXETP00000026595	Homeobox protein cut-like.	Neurl protein.	0.517
fmr1	SHANK3	ENSXETP00000015179	ENSXETP00000039894	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	SH3 and multiple ankyrin repeat domains 3.	0.564
fmr1	caprin1	ENSXETP00000015179	ENSXETP00000016366	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	Leucine rich repeat containing 45.	0.679
fmr1	caprin2	ENSXETP00000015179	ENSXETP00000045707	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	Amphibian RCA protein 3.	0.538
fmr1	cpeb3	ENSXETP00000015179	ENSXETP00000011081	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). Does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). Inhibits differentiation of intermediate mes [...]	0.494
fmr1	ube3a	ENSXETP00000015179	ENSXETP00000048433	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.518
mapk6	mapkapk5	ENSXETP00000052861	ENSXETP00000034912	Protein phosphatase 2, catalytic subunit, beta isozyme.	Protein kinase domain-containing protein.	0.819
mapk6	ube3a	ENSXETP00000052861	ENSXETP00000048433	Protein phosphatase 2, catalytic subunit, beta isozyme.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.483
mapkapk5	mapk6	ENSXETP00000034912	ENSXETP00000052861	Protein kinase domain-containing protein.	Protein phosphatase 2, catalytic subunit, beta isozyme.	0.819

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